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Shifting transmission risk for malaria in Africa with climate change: a framework for planning and intervention

May 4, 2020 - 15:27 -- Open Access
Sadie J. Ryan, Catherine A. Lippi and Fernanda Zermoglio
Malaria Journal 2020 19:170, 1 May 2020

Malaria continues to be a disease of massive burden in Africa, and the public health resources targeted at surveillance, prevention, control, and intervention comprise large outlays of expense. Malaria transmission is largely constrained by the suitability of the climate for Anopheles mosquitoes and Plasmodium parasite development. Thus, as climate changes, shifts in geographic locations suitable for transmission, and differing lengths of seasons of suitability will occur, which will require changes in the types and amounts of resources.

Evaluating malaria programmes in moderate- and low-transmission settings: practical ways to generate robust evidence

February 22, 2020 - 16:45 -- Open Access
Ruth A. Ashton, Debra Prosnitz, Andrew Andrada, Samantha Herrera and Yazoumé Yé
Malaria Journal 2020 19:75, 18 February 2020

Many countries have made substantial progress in scaling-up and sustaining malaria intervention coverage, leading to more focalized and heterogeneous transmission in many settings. Evaluation provides valuable information for programmes to understand if interventions have been implemented as planned and with quality, if the programme had the intended impact on malaria burden, and to guide programmatic decision-making. Low-, moderate-, and heterogeneous-transmission settings present unique evaluation challenges because of dynamic and targeted intervention strategies. This paper provides illustration of evaluation approaches and methodologies for these transmission settings, and suggests how to answer evaluation questions specific to the local context.

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes

January 15, 2020 - 09:25 -- Open Access
Jennison C, Lucantoni L, O'Neill MT, McConville R, Erickson SM, Cowman AF, Sleebs BE, Avery VM, Boddey JA
Cell Reports Volume 29, ISSUE 12, P 3796-3806.e4 December 17, 2019

Plasmodium falciparum gametocytes infect mosquitoes and are responsible for malaria transmission. New interventions that block transmission could accelerate malaria elimination. Gametocytes develop within erythrocytes and activate protein export pathways that remodel the host cell. Plasmepsin V (PMV) is an aspartyl protease that is required for protein export in asexual parasites, but its function and essentiality in gametocytes has not been definitively proven, nor has PMV been assessed as a transmission-blocking drug target.

NOT Open Access | Assessing the role of human mobility on malaria transmission

January 15, 2020 - 07:49 -- NOT Open Access
Mukhtar AYA, Munyakazi JB, Ouifki R
Mathematical Biosciences, Volume 320, February 2020, 108304

South Sudan accounts for a large proportion of all annual malaria cases in Africa. In recent years, the country has witnessed an unprecedented number of people on the move, refugees, internally displaced people, people who have returned to their counties or areas of origin, stateless people and other populations of concern, posing challenges to malaria control.

Can Plasmodium's tricks for enhancing its transmission be turned against the parasite? New hopes for vector control

January 14, 2020 - 12:10 -- Open Access
Emami SN, Hajkazemian M, Mozūraitis R
Pathogens and Global Health, 2020 Jan 7:1-11

Approximately 120 years ago the link between mosquito and the malaria transmission was discovered. However, even today it remains an open question whether the parasite is able to direct the blood-seeking and feeding behavior of its mosquito vector to maximize the probability of transmission. If the parasite has this ability, could it occur only through the alteration of the vertebrate host’s volatile organic compounds (VOCs) and/or the parasite alteration of the behavior of the infected vector in a manner that favors its transmission?

NOT Open Access | Climate Change and the Risk of Malaria Transmission in Iran

January 14, 2020 - 09:28 -- NOT Open Access
Hanafi-Bojd AA, Vatandoost H, Yaghoobi-Ershadi MR
Journal of Medical Entomology, Volume 57, Issue 1, January 2020, Pages 50–64

Climate change is an important factor affecting the dynamics of the vectors population and, hence, the risk of vector-borne diseases. This study aimed to predict the environmental suitability for malaria vectors in Iran under climate change scenarios in 2030s and 2050s. Literature search was performed to find documents on the spatial distribution of Anopheles stephensi Liston, 1901, Anopheles culicifacies s.l. Giles, 1901, Anopheles fluviatilis s.l. James, 1902, Anopheles superpictus s.l. Grassi, 1899, Anopheles dthali Patton, 1905, Anopheles maculipennis s.l. Meigen, 1818, and Anopheles sacharovi Favre, 1903 (Diptera: Culicidae) published between 1970 and 2017.

Upsurge of malaria transmission after indoor residual spraying withdrawal in Atacora region in Benin, West Africa

January 7, 2020 - 14:52 -- Open Access
Rock Yves Aïkpon, Gil Padonou, Martin Akogbéto, et al.
Malaria Journal 2020 19:3, 3 January 2020

In Benin, malaria vector control mostly relies on long-lasting, insecticidal-treated bed nets (LLINs) and indoor residual spraying (IRS) operations. From 2011 to 2016, an IRS programme has been implemented in Atacora region. However, in 2017 the programme was withdrawn from two other regions in the northern part of the country, with hopes that gains would be relatively sustained because of the seasonality of malaria transmission. What would be the vulnerability of populations to malaria after the withdrawal of IRS?

From Africa to Europe: evidence of transmission of a tropical Plasmodium lineage in Spanish populations of house sparrows

November 30, 2019 - 12:34 -- Open Access
Ferraguti M, Martínez-de la Puente J, García-Longoria L, Soriguer R, Figuerola J, Marzal A
Parasit Vectors. 2019 Nov 21;12(1):548

Avian malaria parasites are a highly diverse group that commonly infect birds and have deleterious effects on their hosts. Some parasite lineages are geographically widespread and infect many host species in many regions. Bird migration, natural dispersal, invasive species and human-mediated introductions into areas where competent insect vectors are present, are probably the main drivers of the current distribution of avian malaria parasites.

Anopheles cinereus implicated as a vector of malaria transmission in the highlands of north-west Ethiopia

November 28, 2019 - 06:29 -- Open Access
Lemma W, Alemu K, Birhanie M, Worku L, Niedbalski J, McDowell MA, Lobo NF.
Parasites & Vectors volume 12, Article number: 557 (2019)

Transmission of malaria in the highlands of Ethiopia is poorly understood and usually attributed to importation by mobile populations or local transmission by Anopheles arabiensis. To characterize and identify Anopheles species present in a highland area of northern Ethiopia, adult and larval collections were performed in Gondar town and the neighboring Senbet Debir village (Dembia district, > 2000 meters above sea level, masl), in addition to Bahir Dar town (capital of Amhara region) and Kumer Aftit village (Metema district, < 2000 masl).


Spatio-temporal analysis of association between incidence of malaria and environmental predictors of malaria transmission in Nigeria

November 27, 2019 - 16:17 -- Open Access
Okunlola OA, Oyeyemi OT
Sci Rep. 2019 Nov 25;9(1):17500.

Malaria still poses a significant threat in Nigeria despite the various efforts to abate its transmission. Certain environmental factors have been implicated to increase the risk of malaria in Nigeria and other affected countries. The study aimed to evaluate the spatial and temporal association between the incidence of malaria and some environmental risk factors in Nigeria. The study used malaria incidence and environmental risk factors data emanating from 2015 Nigeria Malaria Indicator Survey accessed from the Demographic and Health Survey database.



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