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pyrethroid resistance

Performance of IRS on malaria prevalence and incidence using pirimiphos-methyl in the context of pyrethroid resistance in Koulikoro region, Mali

August 17, 2020 - 13:22 -- Open Access
Author(s): 
Fousseyni Kané, Moussa Keïta, Boïssé Traoré, Sory Ibrahim Diawara, Sidy Bane, Souleymane Diarra, Nafomon Sogoba and Seydou Doumbia
Reference: 
Malaria Journal 2020 19:286, 12 August 2020

Koulikoro Health District is one of three districts of Mali where the indoor residual spray (IRS) has been implemented from 2008 to 2016. With widespread of resistance to pyrethroid, IRS was shifted from pyrethroid to pirimiphos-methyl from 2014 to 2016. The objective of this study was to assess the added value of IRS to LLINs on the prevalence of parasitaemia and malaria incidence among children under 10 years old.

NOT Open Access | Preliminary Report of Pyrethroid Resistance in Anopheles vagus, an Important Malaria Vector in Bangladesh

August 12, 2020 - 15:10 -- NOT Open Access
Author(s): 
Alam MS, Al-Amin HM, Khan WA, Haque R, Nahlen BL, Lobo NF
Reference: 
Am J Trop Med Hyg. 2020 Aug;103(2):810-811

According to the WHO, unmanaged insecticide resistance may lead to increases in malaria-related mortality and morbidity. Bangladesh, having made significant progress in malaria control efforts, has recently seen an upswing in malaria cases-58% of which occurred in Bandarban district. Toward identifying entomological drivers of increased malaria, an entomological survey including Anopheles susceptibility to the insecticides in use was conducted in Bandarban.

NOT Open Access | Preliminary Report of Pyrethroid Resistance in Anopheles vagus, an Important Malaria Vector in Bangladesh

May 13, 2020 - 14:44 -- NOT Open Access
Author(s): 
Alam MS, Al-Amin HM, Khan WA, Haque R, Nahlen BL, Lobo NF
Reference: 
Am J Trop Med Hyg. 2020 May 11

According to the WHO, unmanaged insecticide resistance may lead to increases in malaria-related mortality and morbidity. Bangladesh, having made significant progress in malaria control efforts, has recently seen an upswing in malaria cases—58% of which occurred in Bandarban district.

Anopheles gambiae (s.l.) exhibit high intensity pyrethroid resistance throughout Southern and Central Mali (2016-2018): PBO or next generation LLINs may provide greater control

May 12, 2020 - 17:47 -- Open Access
Author(s): 
Sovi A, Keita C, Oxborough RM, et al.
Reference: 
Parasit Vectors. 2020 May 8;13(1):239

Millions of pyrethroid LLINs have been distributed in Mali during the past 20 years which, along with agricultural use, has increased the selection pressure on malaria vector populations. This study investigated pyrethroid resistance intensity and susceptible status of malaria vectors to alternative insecticides to guide choice of insecticides for LLINs and IRS for effective control of malaria vectors.

Intensity of pyrethroid resistance in Anopheles gambiae before and after a mass distribution of insecticide-treated nets in Kinshasa and in 11 provinces of the Democratic Republic of Congo

May 4, 2020 - 15:17 -- Open Access
Author(s): 
Francis Wat’senga, Fiacre Agossa, Seth R. Irish, et al.
Reference: 
Malaria Journal 2020 19:169, 30 April 2020

Between 2011 and 2018, an estimated 134.8 million pyrethroid-treated long-lasting insecticidal nets (LLINs) were distributed nationwide in the Democratic Republic of Congo (DRC) for malaria control. Pyrethroid resistance has developed in DRC in recent years, but the intensity of resistance and impact on LLIN efficacy was not known. Therefore, the intensity of resistance of Anopheles gambiae sensu lato (s.l.) to permethrin and deltamethrin was monitored before and after a mass distribution of LLINs in Kinshasa in December 2016, and in 6 other sites across the country in 2017 and 11 sites in 2018.

NOT Open Access | Intensity of pyrethroid resistance in Anopheles culicifacies s.l. (Diptera: Culicidae) in Odisha State, India

April 13, 2020 - 15:14 -- NOT Open Access
Author(s): 
Sahu SS, Thankachy S, Dash S, Kasinathan G, Kumar A
Reference: 
Pathog Glob Health. 2020 Apr 10:1-7.

Anopheles culicifacies s.l. is the principal malaria vector in India and has recently developed resistance to synthetic pyrethroids. For identifying the possible operational impact, quantitative measure of the intensity of this resistance is required. The purpose of this study was to measure the intensity of pyrethroid resistance in An. culicifacies s.l.

Use of alternative bioassays to explore the impact of pyrethroid resistance on LLIN efficacy

April 10, 2020 - 17:18 -- Open Access
Author(s): 
Grossman MK, Oliver SV, Brooke BD, Thomas MB
Reference: 
Parasit Vectors. 2020 Apr 7;13(1):179

There is substantial concern that the spread of insecticide resistance will render long-lasting insecticide-treated nets (LLINs) ineffective. However, there is limited evidence supporting a clear association between insecticide resistance and malaria incidence or prevalence in the field. We suggest that one reason for this disconnect is that the standard WHO assays used in surveillance to classify mosquito populations as resistant are not designed to determine how resistance might impact LLIN efficacy. The standard assays expose young, unfed female mosquitoes to a diagnostic insecticide dose in a single, forced exposure, whereas in the field, mosquitoes vary in their age, blood-feeding status, and the frequency or intensity of LLIN exposure. These more realistic conditions could ultimately impact the capacity of “resistant” mosquitoes to transmit malaria.

The effectiveness of older insecticide-treated bed nets (ITNs) to prevent malaria infection in an area of moderate pyrethroid resistance: results from a cohort study in Malawi

January 20, 2020 - 15:44 -- Open Access
Author(s): 
Monica P. Shah, Laura C. Steinhardt, Dyson Mwandama, Themba Mzilahowa, John E. Gimnig, Andy Bauleni, Jacklyn Wong, Ryan Wiegand, Don P. Mathanga and Kim A. Lindblade
Reference: 
Malaria Journal 2020 19:24, 15 January 2020

A previous cohort study in Malawi showed that users of new insecticide-treated bed nets (ITNs) were significantly protected against malaria compared to non-users, despite moderate levels of pyrethroid resistance among the primary mosquito vectors. The present study investigated whether ITNs that were 1–2 years old continued to protect users in the same area with moderate pyrethroid resistance.

Genetic basis of pyrethroid resistance in a population of Anopheles arabiensis, the primary malaria vector in Lower Moshi, north-eastern Tanzania

July 1, 2014 - 18:05 -- Open Access
Author(s): 
Matowo J, Jones CM, Kabula B, Ranson H, Steen K, Mosha F, Rowland M, Weetman D
Reference: 
Parasites & Vectors 2014, 7 :274 (19 June 2014)

Our study provides replication of CYP4G16 as a candidate gene for pyrethroid resistance in An. arabiensis, although its role may not be in detoxification, and requires further investigation.

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