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pyronaridine

Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor

April 6, 2020 - 13:00 -- Open Access
Author(s): 
Matthias Rottmann, Brian Jonat, Thomas Spangenberg, et al.
Reference: 
Antimicrob. Agents Chemother. March 2020 64:e02181-19

Antimalarial drug resistance in the Plasmodium falciparum parasite poses a constant challenge for drug development. To mitigate this risk, new antimalarial medicines should be developed as fixed-dose combinations. Assessing the pharmacodynamic interactions of potential antimalarial drug combination partners during early phases of development is essential in developing the targeted parasitological and clinical profile of the final drug product.

Preclinical Antimalarial Combination Studies: The Case of M5717, a P. falciparum Elongation Factor 2 Inhibitor and Pyronaridine, a Hemozoin Formation Inhibitor

February 17, 2020 - 14:33 -- Open Access
Author(s): 
Rottmann M, Jonat B, Spangenberg T, et al.
Reference: 
Antimicrob Agents Chemother. 2020 Feb 10, pii: AAC.02181-19.

Antimalarial drug resistance in the Plasmodium falciparum parasite poses a constant challenge for drug development. To mitigate this risk, new antimalarial medicines should be developed as fixed-dose combinations. Assessing the pharmacodynamic interactions of potential antimalarial drug combination partners during early phases of development is essential in developing the targeted parasitological and clinical profile of the final drug product.

In vitro interaction of lumefantrine and piperaquine by atorvastatin against Plasmodium falciparum

June 9, 2014 - 16:30 -- Open Access
Author(s): 
Dormoi J, Savini H, Amalvict R, Baret E, Pradines B
Reference: 
Malaria Journal 2014, 13 :189 (25 May 2014)

Even though in vitro data indicate that atorvastatin improved the activity of lumefantrine and piperaquine, the same may not necessarily be true in vivo.

Medical Treatment: 
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