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RDT

NOT Open Access | Clinical Impact of Malaria Rapid Diagnostic Testing at a US Children's Hospital

July 20, 2020 - 08:09 -- NOT Open Access
Author(s): 
Enane LA, Sullivan KV, Spyridakis E, Feemster KA
Reference: 
J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):298-304

Children who develop malaria after returning to a setting in which the disease is not endemic are at high risk for critical delays in diagnosis and initiation of antimalarial therapy. We assessed the clinical impact of the implementation of malaria rapid diagnostic testing (RDT) on the management of children with malaria at an urban US children’s hospital that serves a large immigrant population.

Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

July 15, 2020 - 15:17 -- Open Access
Author(s): 
Ruben O. Conner, Yakou Dieye, Caterina Guinovart, et al.
Reference: 
Malaria Journal 2020 19:252, 14 July 2020

Population-wide interventions using malaria testing and treatment might decrease the reservoir of Plasmodium falciparum infection and accelerate towards elimination. Questions remain about their effectiveness and evidence from different transmission settings is needed.

Keep the quality high: the benefits of lot testing for the quality control of malaria rapid diagnostic tests

July 14, 2020 - 09:42 -- Open Access
Author(s): 
Sandra Incardona, David Bell, Xavier C. Ding, et al.
Reference: 
Malaria Journal 2020 19:247, 13 July 2020

The production and use of malaria rapid diagnostic tests (RDTs) has risen dramatically over the past 20 years. In view of weak or non-existing in vitro diagnostics (IVD) regulations and post-marketing surveillance (PMS) systems in malaria endemic countries, the World Health Organization, later joined by the Foundation for Innovative New Diagnostics, established an independent, centralized performance evaluation and Lot Testing (LT) programme to safeguard against poor quality of RDTs being distributed through the public health sector of malaria endemic countries. RDT performances and manufacturer quality management systems have evolved over the past decade raising questions about the future need for a centralized LT programme.

Droplet digital polymerase chain reaction (ddPCR) for the detection of Plasmodium knowlesi and Plasmodium vivax

July 14, 2020 - 09:19 -- Open Access
Author(s): 
Punitha Mahendran, Jonathan Wee Kent Liew, Amirah Amir, Xiao-Teng Ching and Yee-Ling Lau
Reference: 
Malaria Journal 2020 19:241, 10 July 2020

Plasmodium knowlesi and Plasmodium vivax are the predominant Plasmodium species that cause malaria in Malaysia and play a role in asymptomatic malaria disease transmission in Malaysia. The diagnostic tools available to diagnose malaria, such as microscopy and rapid diagnostic test (RDT), are less sensitive at detecting lower parasite density. Droplet digital polymerase chain reaction (ddPCR), which has been shown to have higher sensitivity at diagnosing malaria, allows direct quantification without the need for a standard curve. The aim of this study is to develop and use a duplex ddPCR assay for the detection of P. knowlesi and P. vivax, and compare this method to nested PCR and qPCR.

Evidence for Reduced Malaria Parasite Population after Application of Population-Level Antimalarial Drug Strategies in Southern Province, Zambia

July 7, 2020 - 12:48 -- Open Access
Author(s): 
Daniels RF, Schaffner SF, Bennett A, Porter TR, Yukich JO, Mulube C, Mambwe B, Mwenda MC, Chishimba S, Bridges DJ, Moonga H, Hamainza B, Chizema Kawesha E, Miller JM, Steketee RW, Wirth DF, Eisele TP, Hartl DL, Volkman SK
Reference: 
Am. J. Trop. Med. Hyg., 00(0), 2020, pp. 1–8

A mass drug administration trial was carried out in Southern Province, Zambia, between 2014 and 2016, in conjunction with a standard of care package that included improved surveillance, increased access to malaria case management, and sustained high levels of vector control coverage. This was preceded by mass test and treatment in the same area from 2011 to 2013. Concordant decreases in malaria prevalence in Southern Province and deaths attributed to malaria in Zambia over this time suggest that these strategies successfully reduced the malaria burden.

Rapid diagnostic test supply chain and consumption study in Cabo Delgado, Mozambique: estimating stock shortages and identifying drivers of stock-outs

August 13, 2014 - 17:09 -- Open Access
Author(s): 
Hasselback L, Crawford J, Chaluco T, Rajagopal S, Prosser W, Watson N
Reference: 
Malaria Journal 2014, 13 :295 (2 August 2014)

A longitudinal cross-sectional study was conducted to evaluate drivers of stock shortages in the Cabo Delgado province.

Country: 

Paracheck® rapid diagnostic test for detecting malaria infection in under five children: a population-based survey in Burkina Faso

April 18, 2014 - 15:59 -- Open Access
Tags: 
Author(s): 
Samadoulougou S, Kirakoya-Samadoulougou F, Sarrassat S, Tinto H, Bakiono F, Nebié I, Robert A
Reference: 
Malaria Journal 2014, 13 :101 (17 March 2014)

These results suggest that Paracheck® is not suitable to assess malaria infection prevalence at community level in areas with high malaria transmission. In such settings, malaria prevalence in the general population could be estimated using microscopy.

Country: 

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