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NOT Open Access | Evaluating the dual reactivity on SD bioline malaria rapid diagnosis tests as a potential indicator of high parasitemia due to Plasmodium falciparum

July 28, 2021 - 14:17 -- NOT Open Access
Nana RRD, Makoge V, Ngum NL, Amvongo-Adjia N, Singh V, Somo RM
Pathog Glob Health. 2021 Jul 26:1-9

The co-reactivity of the Plasmodium histidine-rich protein 2 (HRP2) and lactate dehydrogenase (pLDH) in malaria rapid diagnosis tests (mRDTs) as a potential indicator of high parasitemia linked to Plasmodium falciparum was evaluated in the reported study from Cameroon. The samples were screened for malaria using both mRDTs (SD bioline HRP2/pLDH), light microscopy and further confirmed by Plasmodium species-specific PCR assay.

Clustering of subpatent infections in households with asymptomatic rapid diagnostic test-positive cases in Bioko Island, Equatorial Guinea independent of travel to regions of higher malaria endemicity: a cross-sectional study

July 14, 2021 - 11:13 -- Open Access
Dianna E. B. Hergott, Jennifer E. Balkus, Sean C. Murphy, et al.
Malaria Journal 2021 20:313, 12 July 2021

Prevalence of falciparum malaria on Bioko Island remains high despite sustained, intensive control. Progress may be hindered by high proportions of subpatent infections that are not detected by rapid diagnostic tests (RDT) but contribute to onward transmission, and by imported infections. Better understanding of the relationship between subpatent infections and RDT-detected infections, and whether this relationship is different from imported versus locally acquired infections, is imperative to better understand the sources of infection and mechanisms of transmission to tailor more effective interventions.

Not Open Access | Defeating malaria in the North-East region: the forerunner for malaria elimination in India

July 14, 2021 - 10:55 -- NOT Open Access
Dev V, Manguin S
Acta Trop. 2021 Jul 9:106040

India is a malaria endemic country which is targeting malaria elimination by 2027. Transmission intensities are low-to-moderate depending on the region supported by multiple disease vectors. Among these, comparatively North-East India contributes to high proportions of malaria cases annually, the majority of which are due to Plasmodium falciparum (90%). Anopheles minimus and An. baimaii (sibling species in the An. dirus complex) are widely prevalent and incriminated as vectors of malaria.

NOT Open Access | Evaluation of the combination of rapid diagnostic tests and microscopy for imported malaria surveillance in Anhui Province, China

July 14, 2021 - 10:18 -- NOT Open Access
Li W, Zhang X, Feng J, Zhang T, Xu X, Jiang J, Wang S, Lyu X, Li S, Lu M
Acta Trop. 2021 Jul 9:106042

In the Anhui Province, China, efforts to interrupt the local malaria transmission were successful, with no endemic cases reported since 2014. Contrastingly, imported malaria cases are still being reported, indicating a disease reintroduction risk after years of elimination. A good surveillance system is key for avoiding the risk, detecting imported cases and possible cases associated with local transmission early. Therefore, rapid diagnostic tests (RDTs) were combined with microscopy to strengthen malaria surveillance in the province. Herein, we aimed to evaluate the efficacy of this surveillance strategy.

Malaria prevalence and long-lasting insecticidal net use in rural western Uganda: results of a cross-sectional survey conducted in an area of highly variable malaria transmission intensity

July 7, 2021 - 14:50 -- Open Access
Claire M. Cote, Varun Goel, Rabbison Muhindo, Emmanuel Baguma, Moses Ntaro, Bonnie E. Shook-Sa, Raquel Reyes, Sarah G. Staedke, Edgar M. Mulogo and Ross M. Boyce
Malaria Journal 2021 20:304, 5 July 2021

Long-lasting insecticidal nets (LLINs) remain a cornerstone of malaria control, but strategies to sustain universal coverage and high rates of use are not well-defined. A more complete understanding of context-specific factors, including transmission intensity and access to health facilities, may inform sub-district distribution approaches and tailored messaging campaigns.

Not Open Access | When local phytotherapies meet biomedicine. Cross-sectional study of knowledge and intercultural practices against malaria in Eastern French Guiana

July 6, 2021 - 14:22 -- NOT Open Access
Odonne G, Musset L, Mosnier E, et al.
J Ethnopharmacol. 2021 Jul 1:114384

In French Guiana, traditional phytotherapies are an important part of self-healthcare, however, a precise understanding of the interactions between local phytotherapies and biomedicine is lacking. Malaria is still endemic in the transition area between French Guiana and Brazil, and practices of self-treatment, although difficult to detect, have possible consequences on the outcome of public health policies.

Not Open Access | First evidence of local circulation of Plasmodium ovale curtisi and reliability of a malaria rapid diagnostic test among symptomatic outpatients in Douala, Cameroon

July 6, 2021 - 14:16 -- NOT Open Access
Kojom Foko LP, Kouemo Motse FD, Kamgain Mawabo L, Pande V, Singh V
Infect Genet Evol. 2021 Jul;91:104797

The performances of a commonly used Plasmodium falciparum-detecting rapid diagnostic test (RDT) were determined in symptomatic individuals living in Cameroon. Discrepancies between RDT and light microscopy (LM) results were further investigated, with a focus on non-falciparum malaria (NFM) which are still largely understudied in sub-Saharan Africa (sSA) countries. In the present study, a total of 355 individuals aged 1-65 years were enrolled in the study. Their signs/symptoms and sociodemographic characteristics were documented.

Malaria and dengue in Hodeidah city, Yemen: High proportion of febrile outpatients with dengue or malaria, but low proportion co-infected

June 30, 2021 - 09:43 -- Open Access
Abdul-Ghani R, Mahdy MAK, Alkubati S, Al-Mikhlafy AA, Alhariri A, Das M, Dave K, Gil-Cuesta J
PLoS One. 2021 Jun 25;16(6):e0253556

The emergence of dengue in malaria-endemic countries with limited diagnostic resources, such as Yemen, can be problematic because presumptive treatment of febrile cases as being malaria is a common practice. Co-infections with dengue and malaria are often overlooked and misdiagnosed as being a mono-infection because of clinical similarities. In Hodeidah city, Yemen, the capacity to conduct the diagnosis can be aggravated by the war context. To assess the magnitude of the problem, we determined the proportions of malaria, dengue and co-infection in relation to clinical characteristics among febrile outpatients.

Malaria risk factors in northern Namibia: The importance of occupation, age and mobility in characterizing high-risk populations

June 30, 2021 - 09:29 -- Open Access
Smith JL, Mumbengegwi D, Haindongo E, Cueto C, Roberts KW, Gosling R, Uusiku P, Kleinschmidt I, Bennett A, Sturrock HJ
PLoS One. 2021 Jun 25;16(6):e0252690

In areas of low and unstable transmission, malaria cases occur in populations with lower access to malaria services and interventions, and in groups with specific malaria risk exposures often away from the household. In support of the Namibian National Vector Borne Disease Program's drive to better target interventions based upon risk, we implemented a health facility-based case control study aimed to identify risk factors for symptomatic malaria in Zambezi Region, northern Namibia.

Diagnosis of Chikungunya virus in febrile patients from a malaria holoendemic area

June 29, 2021 - 14:10 -- Open Access
Ingoba LL, Adedoja A, Ntoumi F, et al.
Int J Infect Dis. 2021 Jun 23:S1201-9712(21)00533-6

Accurate diagnosis of chikungunya is essential for effective disease management and surveillance. In a cohort of febrile Congolese patients, we evaluated available diagnostic methods widely used in chikungunya diagnosis. In addition, plasma cytokines were quantified in chikungunya patients and in patients coinfected with malaria compared with healthy controls.


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