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RDT

NOT Open Access | HRP2/3 Mutation in Recrudescent Plasmodium falciparum Malaria Case Acquired in Ethiopia

October 21, 2020 - 08:17 -- NOT Open Access
Author(s): 
Gefen-Halevi S, Belinson V, Manor U, Gazit Z, Smollan G, Belausov N, Biber A, Schwartz E, Grossman T, Leshem E, Amit S
Reference: 
J Travel Med. 2020 Oct 15:taaa196

A 65-year-old Israeli working in Welkait, Ethiopia, not using malaria prophylaxis, developed fever. Malaria RDT was consistent with non-falciparum malaria (plasmodium LDH+/HRP-) but microscopy showed typical P. falciparum.

Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting

October 1, 2020 - 15:36 -- Open Access
Author(s): 
Du YQ, Ling XX, Jin JJ, Zhou HY, Zhu S, Zhu GD, Wang W, Cao J, Huang JY
Reference: 
Infect Dis Poverty. 2020 Sep 29;9(1):135

As more and more countries approaching the goal of malaria elimination, malaria rapid diagnostic tests (RDT) was recomendated to be a diagnostic strategy to achieve and maintain the statute of malaria free, as it’s less requirments on equipment and experitise than microscopic examination. But there are very few economic evaluations to confirm whether RDT was cost-effective in the setting of malaria elimination. This research aimed to offer evidence for helping decision making on malaria diagnosis strategy.

Evaluating the potential of using urine and saliva specimens for malaria diagnosis in suspected patients in Ghana

October 1, 2020 - 15:32 -- Open Access
Author(s): 
Enoch Aninagyei, Joseph Abraham, Paul Atiiga, Shadrach Duodu Antwi, Stephen Bamfo and Desmond Omane Acheampong
Reference: 
Malaria Journal 2020 19:349, 29 September 2020

This study aimed at detecting PfHRP2 and pLDH malaria antigens in urine and salivary specimens of suspected malaria patients using RDT kits, and identifying factors influencing the detection of these antigens.

Contribution of P. falciparum parasites with Pfhrp 2 gene deletions to false negative PfHRP 2 based malaria RDT results in Ghana: A nationwide study of symptomatic malaria patients

September 8, 2020 - 12:32 -- Open Access
Author(s): 
Amoah LE, Abuaku B, Bukari AH, Dickson D, Amoako EO, Asumah G, Asamoah A, Preprah NY, Malm KL
Reference: 
PLoS One. 2020 Sep 4;15(9):e0238749

False-negative malaria rapid diagnostic test (RDT) results amongst symptomatic malaria patients are detrimental as they could lead to ineffective malaria case management. This study determined the nationwide contribution of parasites with Pfhrp2 and Pfhrp 3 gene deletions to false negative malaria RDT results in Ghana.

Insecticide resistance in indoor and outdoor-resting Anopheles gambiae in Northern Ghana

September 1, 2020 - 10:24 -- Open Access
Author(s): 
Majidah Hamid-Adiamoh, Alfred Amambua-Ngwa, Davis Nwakanma, Umberto D’Alessandro, Gordon A. Awandare and Yaw A. Afrane
Reference: 
Malaria Journal 2020 19:314, 31 August 2020

Selection pressure from continued exposure to insecticides drives development of insecticide resistance and changes in resting behaviour of malaria vectors. There is need to understand how resistance drives changes in resting behaviour within vector species. The association between insecticide resistance and resting behaviour of Anopheles gambiae sensu lato (s.l.) in Northern Ghana was examined.

Active case detection of malaria in pregnancy using loop-mediated amplification (LAMP): a pilot outcomes study in South West Ethiopia

September 1, 2020 - 09:45 -- Open Access
Author(s): 
Guluma Tadesse, Claire Kamaliddin, Cody Doolan, Ranmalee Amarasekara, Ruth Legese, Abu Naser Mohon, James Cheaveau, Delenasaw Yewhalaw and Dylan R. Pillai
Reference: 
Malaria Journal 2020 19:305, 27 August 2020

125 million women are pregnant each year in malaria endemic areas and are, therefore, at risk of Malaria in Pregnancy (MiP). MiP is the direct consequence of Plasmodium infection during pregnancy. The sequestration of Plasmodium falciparum parasites in the placenta adversely affects fetal development and impacts newborn birth weight. Importantly, women presenting with MiP commonly develop anaemia. In Ethiopia, the Ministry of Health recommends screening symptomatic women only at antenatal care visits with no formal intermittent preventive therapy. Since MiP can display low-level parasitaemia, current tests which include microscopy and RDT are challenged to detect these cases. Loop mediated isothermal Amplification (LAMP) technology is a highly sensitive technique for DNA detection and is field compatible. This study aims to evaluate the impact of active malaria case detection during pregnancy using LAMP technology in terms of birth outcomes.

Differential contribution of Anopheles coustani and Anopheles arabiensis to the transmission of Plasmodium falciparum and Plasmodium vivax in two neighbouring villages of Madagascar

August 27, 2020 - 08:17 -- Open Access
Author(s): 
Goupeyou-Youmsi J, Rakotondranaivo T, Puchot N, Peterson I, Girod R, Vigan-Womas I, Paul R, Ndiath MO, Bourgouin C
Reference: 
Parasit Vectors. 2020 Aug 26;13(1):430

Malaria is still a heavy public health concern in Madagascar. Few studies combining parasitology and entomology have been conducted despite the need for accurate information to design effective vector control measures. In a Malagasy region of moderate to intense transmission of both Plasmodium falciparum and P. vivax, parasitology and entomology have been combined to survey malaria transmission in two nearby villages.

NOT Open Access | Evaluation of PfHRP2 and PfLDH Malaria Rapid Diagnostic Test Performance in Assosa Zone, Ethiopia

August 26, 2020 - 15:32 -- NOT Open Access
Author(s): 
Alemayehu GS, Lopez K, Dieng CC, Lo E, Janies D, Golassa L
Reference: 
Am J Trop Med Hyg. 2020 Aug 24

In malaria-endemic countries, rapid diagnostic tests (RDTs) targeting Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and lactate dehydrogenase (PfLDH) have been widely used. However, little is known regarding the diagnostic performances of these RDTs in the Assosa zone of northwest Ethiopia. The objective of this study was to determine the diagnostic performances of PfHRP2 and PfLDH RDTs using microscopy and quantitative PCR (qPCR) as a reference test.

Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial

August 24, 2020 - 13:25 -- Open Access
Author(s): 
Agius PA, Cutts JC, Fowkes FJI, et al.
Reference: 
PLoS Med. 2020 Aug 20;17(8):e1003177

The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of public health campaigns. We aimed to quantify the effectiveness of repellent distributed by the village health volunteer (VHV) network in the Greater Mekong Subregion (GMS) in reducing malaria in order to advance regional malaria elimination.

A five-year trend analysis of malaria surveillance data in selected zones of Amhara region, Northwest Ethiopia

July 30, 2020 - 13:26 -- Open Access
Author(s): 
Lankir D, Solomon S, Gize A
Reference: 
BMC Public Health. 2020 Jul 28; 20(1):1175

Trend analysis of malaria surveillance data is essential to inform stakeholders on progress towards malaria control. From the total 387,096 cases of malaria reported in Amhara region in 2017, 167,079 (43.2%) cases were in Central, North and West Gondar zones. From this total figure of zones, 15,445 (9.2%) were ≤ 5 years which contributes 4% of cases in the region. So, the purpose of this study was to analyze trends of malaria parasite in Selected Zones of Amhara Region, Northwest Ethiopia.

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