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antimalarial resistance

The WorldWide Antimalarial Resistance Network Clinical Trials Publication Library: A Live, Open-Access Database of Plasmodium Treatment Efficacy Trials

May 21, 2020 - 06:39 -- Open Access
Author(s): 
Takata J, Sondo P, Humphreys GS, Burrow R, Maguire B, Hossain MS, Das D, Commons RJ, Price RN, Guerin PJ
Reference: 
Am J Trop Med Hyg. 2020 May 18

Parasite resistance to antimalarial drugs poses a serious threat to malaria control. The WorldWide Antimalarial Resistance Network (WWARN) aims to provide a collaborative platform to support the global malaria research effort. Here, we describe the “WWARN clinical trials publication library,” an open-access, up-to-date resource to streamline the synthesis of antimalarial safety and efficacy data.

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

May 4, 2020 - 15:20 -- Open Access
Author(s): 
Verity R, Aydemir O, Juliano JJ, et al.
Reference: 
Nat Commun. 2020 Apr 30;11(1):2107

The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine.

Uncovering the ART of antimalarial resistance

January 14, 2020 - 16:51 -- Open Access
Author(s): 
Marapana D, Cowman AF
Reference: 
Science, 03 Jan 2020: Vol. 367, Issue 6473, pp. 22-23

The identification of artemisinin (ART) in 1971 allowed treatment of malaria resistant to chloroquine, the prevailing drug at the time, and provided hope for a malaria-free world (1). Today, malaria control efforts have been very successful, with 32% fewer deaths over the past 8 years (2). However, the emergence of resistance to ART and other antimalarials threatens to become a major problem in the continuing program to eliminate and eventually eradicate malaria (3).

NOT Open Access | Antimalarial Resistance Unlikely To Explain U.K. Artemether-Lumefantrine Failures

June 27, 2017 - 17:58 -- NOT Open Access
Author(s): 
Rob W. van der Pluijm, James Watson, and Charles J. Woodrow
Reference: 
Antimicrob. Agents Chemother. July 2017 vol. 61 no. 7 e00721-17

No abstract available

Mind the gaps - the epidemiology of poor-quality anti-malarials in the malarious world - analysis of the WorldWide Antimalarial Resistance Network database

April 16, 2014 - 19:03 -- Open Access
Author(s): 
Tabernero P, Fernández FM, Green M, Guerin PJ, Newton PN
Reference: 
Malaria Journal 2014, 13 :139 (8 April 2014)

The available evidence demonstrates the need for more investment to improve both sampling and analytical methodology and to achieve consensus in defining different types of poor quality medicines.

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