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The epidemiology and detectability of asymptomatic plasmodium vivax and plasmodium falciparum infections in low, moderate and high transmission settings in Ethiopia

January 27, 2021 - 11:53 -- Open Access
Elifaged Hailemeskel, Surafel K Tebeje, Fitsum G. Tadesse, et al.
Malaria Journal 2021 20:59, 22 January 2021

As countries move to malaria elimination, detecting and targeting asymptomatic malaria infections might be needed. Here, the epidemiology and detectability of asymptomatic Plasmodium falciparum and Plasmodium vivax infections were investigated in different transmission settings in Ethiopia.

Past eight-year malaria data in Gedeo zone, southern Ethiopia: trend, reporting-quality, spatiotemporal distribution, and association with socio-demographic and meteorological variables

January 27, 2021 - 11:21 -- Open Access
Molla E, Behaksra SW, Tadesse FG, Dugassa S, Gadisa E, Mamo H
BMC Infect Dis. 2021 Jan 21;21(1):91

Informed decision making is underlined by all tiers in the health system. Poor data record system coupled with under- (over)-reporting of malaria cases affects the country’s malaria elimination activities. Thus, malaria data at health facilities and health offices are important particularly to monitor and evaluate the elimination progresses. This study was intended to assess overall reported malaria cases, reporting quality, spatiotemporal trends and factors associated in Gedeo zone, South Ethiopia.

NOT Open Access | Patterns of human exposure to early-evening and outdoor biting mosquitoes and residual malaria transmission in Ethiopia

January 27, 2021 - 10:53 -- NOT Open Access
Degefa T, Githeko AK, Lee MC, Yan G, Yewhalaw D
Acta Trop. 2021 Jan 21:105837

Ethiopia has shown a notable progress in reducing malaria burden over the past decade, mainly due to the scaleup of vector control interventions such as long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS). Based on the progress, the country has set goals to eliminate malaria by 2030. However, residual malaria transmission due to early-evening and outdoor biting vectors could pose a challenge to malaria elimination efforts. This study assessed vector behavior, patterns of human exposure to vector bites and residual malaria transmission in southwestern Ethiopia. Anopheles mosquitoes were collected monthly from January to December 2018 using human landing catches (HLCs), human-baited double net traps, CDC light traps and pyrethrum spray catches.

Effectiveness of the school-based social and behaviour change communication interventions on insecticide-treated nets utilization among primary school children in rural Ethiopia: a controlled quasi-experimental design

January 13, 2021 - 10:29 -- Open Access
Fira Abamecha, Morankar Sudhakar, Lakew Abebe, Yohannes Kebede, Guda Alemayehu and Zewdie Birhanu
Malaria Journal 2021 20:41, 13 January 2021

School-based behaviour change communication interventions could help to achieve behavioural changes in the school and enhance the enrollment of the students and teachers as health messengers to local communities. Evidence on the impacts of the school-engaged malaria preventive interventions are limited as far as the social and behaviour change communication (SBCC) is concerned. This study examined the effectiveness of the school-based SBCC approach on insecticide-treated nets (ITNs) utilization among primary school students in malaria-endemic settings of Ethiopia.

In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents

January 6, 2021 - 11:41 -- Open Access
Yonatan Alebachew, Daniel Bisrat, Solomon Tadesse and Kaleab Asres
Malaria Journal 2021 20:3, January 2021

Kniphofia foliosa is a flamboyant robust perennial herb which has dense clumps and tick upright rhizomes with leaves at the base. In Ethiopia, it has several vernacular names including Abelbila, Ashenda, Amelmela, Yeznjero Ageda, Shemetmetie and Yezinjero Ageda. The plant is endemic to Ethiopian highlands, where its rhizomes are traditionally used for the treatment of malaria, abdominal cramps and wound healing. In the present study, the 80% methanol extract of K. foliosa rhizomes and its constituents are tested against Plasmodium berghei in mice.

Trends of Malaria Morbidity and Mortality from 2010 to 2017 in Bale Zone, Ethiopia: Analysis of Surveillance Data

December 16, 2020 - 12:49 -- Open Access
Sani Kalil F, Hasen Bedaso M, Kabeta Wario S
Infect Drug Resist. 2020 Dec 8;13:4379-4387

Malaria is the major public health problem in sub-Saharan Africa, including Ethiopia. Ongoing malaria surveillance data analysis is useful for assessing incidences, trends over time, and evaluating the effectiveness of malaria prevention and control programs.

Malaria epidemiology and stratification of incidence in the malaria elimination setting in Harari Region, Eastern Ethiopia

November 25, 2020 - 12:04 -- Open Access
Esayas E, Tufa A, Massebo F, Ahemed A, Ibrahim I, Dillu D, Bogale EA, Yared S, Deribe K
Infect Dis Poverty. 2020 Nov 22;9(1):160

Ethiopia has shown notable progress in reducing the burden of malaria over the past two decades. Because of this progress, the country has shifted efforts from control to elimination of malaria. This study was conducted to analyse the malaria epidemiology and stratification of incidence in the malaria elimination setting in eastern Ethiopia.

Spatial and genetic clustering of Plasmodium falciparum and Plasmodium vivax infections in a low-transmission area of Ethiopia

November 19, 2020 - 12:54 -- Open Access
Tessema SK, Belachew M, Tadesse FG, et al.
Sci Rep. 2020 Nov 17;10(1):19975

The distribution of malaria infections is heterogeneous in space and time, especially in low transmission settings. Understanding this clustering may allow identification and targeting of pockets of transmission. In Adama district, Ethiopia, Plasmodium falciparum and P. vivax malaria patients and controls were examined, together with household members and immediate neighbors.

Artemether-lumefantrin treatment adherence among uncomplicated plasmodium falciparum malaria patients, visiting public health facilities in AsgedeTsimbla district, Tigray, Ethiopia: a cross-sectional study

November 11, 2020 - 12:52 -- Open Access
Gebrekidan MG, Gebremedhin GB, Gebregiorgis YS, Gezehegn AA, Weldearegay KT
Antimicrob Resist Infect Control. 2020 Nov 10;9(1):184

Ethiopia has set a goal to eliminate malaria by 2030; Artemether–lumefantrine (AL) is put as one of the cornerstone strategies for uncomplicated plasmodium falciparum malaria treatment. However, only focusing on prescribing of the treatment without assessing patients’ adherence could lead to the resistance of the drug. In Ethiopia, there is limited evidence about patients’ adherence to AL and its influencing factors. Therefore, this study aimed at addressing this information gap.

High prevalence and extended deletions in Plasmodium falciparum hrp2/3 genomic loci in Ethiopia

November 10, 2020 - 13:07 -- Open Access
Golassa L, Messele A, Amambua-Ngwa A, Swedberg G
PLoS One. 2020 Nov 5;15(11):e0241807

Deletions in Plasmodium falciparum histidine rich protein 2(pfhrp2) gene threaten the usefulness of the most widely used HRP2-based malaria rapid diagnostic tests (mRDTs) that cross react with its structural homologue, PfHRP3. Parasites with deleted pfhrp2/3 genes remain undetected and untreated due to 'false-negative' RDT results. As Ethiopia recently launched malaria elimination by 2030 in certain selected areas, the availability of RDTs and the scale of their use have rapidly increased in recent years.


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