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Evaluation of the Antimalarial Activity of Ethanol Extracts of the Leaves of Three Plant Species Collected from Yayu Coffee Forest Biosphere Reserve, Southwest Ethiopia

July 21, 2021 - 18:18 -- Open Access
Yeshanew S, Gete W, Chilo D
J Exp Pharmacol. 2021 Jul 14;13:661-668

In the attempt of searching for potential plant derived antimalarial medicines, the aim of the present study was to examine In vivo antimalarial efficacy of crude ethanol extracts of the leaves of Croton macrostachyus, Ruta chalepensis and Vernonia amygdalina using chloroquine (CQ) sensitive strains of Plasmodium berghei in Swiss albino mice.

Sequence analysis of Plasmodium vivax Duffy binding proteins reveals the presence of unique haplotypes and diversifying selection in Ethiopian isolates

July 14, 2021 - 11:10 -- Open Access
Lemu Golassa, Alebachew Messele, Eniyou Cheryll Oriero and Alfred Amambua-Ngwa
Malaria Journal 2021 20:312, 10 July 2021

Red blood cell invasion by the Plasmodium vivax merozoite requires interaction between the Duffy antigen receptor for chemokines (DARC) and the P. vivax Duffy-binding protein II (PvDBPII). Given that the disruption of this interaction prevents P. vivax blood-stage infection, a PvDBP-based vaccine development has been well recognized. However, the polymorphic nature of PvDBPII prevents a strain transcending immune response and complicates attempts to design a vaccine.

Effectiveness of long-lasting insecticidal nets in prevention of malaria among individuals visiting health centres in Ziway-Dugda District, Ethiopia: matched case–control study

July 7, 2021 - 14:44 -- Open Access
Mesfin Kelkile Wubishet, Gebretsadik Berhe, Alefech Adissu and Mesfin Segni Tafa
Malaria Journal 2021 20:301, 3 July 2021

Malaria is a major health problem in Ethiopia. Sleeping under long-lasting insecticidal nets (LLINs) is its major control strategy. Despite high LLINs use (84%) in Ziway-Dugda District, malaria remained a public health problem, raising concern on its effectiveness. Understanding the effectiveness of malaria control interventions is vital. This study evaluated the effectiveness of LLINs and determinants of malaria in Ziway-Dugda District, Arsi Zone Ethiopia.

Malaria prevalence, knowledge, attitude, and practice among febrile patients attending Chagni health center, Northwest Ethiopia: a cross-sectional study

July 6, 2021 - 14:32 -- Open Access
Belay B, Gelana T, Gebresilassie A
Trop Dis Travel Med Vaccines. 2021 Jul 5;7(1):20

Ethiopia has achieved considerable progresses in the prevention and control of malaria in the past decades; hitherto it is a formidable health concern and socio-economic impediment. This study aimed at assessing the magnitude, knowledge, attitudes and practices towards malaria among febrile patients attending Chagni health center, northwest Ethiopia.

Comparison of capillary, venous and buffy coat blood samples in detecting Plasmodium species among malaria suspected patients attending at Hamusite health center. A cross-sectional study

June 23, 2021 - 13:23 -- Open Access
Abeje G, Gelaye W, Alemu G
BMC Infect Dis. 2021 Jun 15;21(1):576

Both capillary and venous blood samples have been interchangeably used for the diagnosis of malaria in Ethiopia. However, Plasmodium parasites are thought to be more concentrated in capillary than in venous blood. Hence, selecting a sample source where parasites are more concentrated is indispensable approach in order to maximize the accuracy of blood film microscopy. Therefore, the present study aimed to compare the detection rate and the parasitemia level of Plasmodium species from conventional capillary and venous blood films, and buffy coat preparations.

Perceived sustainability of the school-based social and behavior change communication (SBCC) approach on malaria prevention in rural Ethiopia: stakeholders' perspectives

June 22, 2021 - 15:04 -- Open Access
Abamecha F, Midaksa G, Sudhakar M, Abebe L, Kebede Y, Alemayehu G, Birhanu Z
BMC Public Health. 2021 Jun 18;21(1):1171

Evidence on what makes the school-engaged social and behavior change communication (SBCC) interventions on malaria prevention more sustainable are limited in literature partly due to its recent emergence. Enrolling the key stakeholders, this study explored the perceived sustainability of the SBCC interventions on malaria prevention through primary school communities in rural Ethiopia.

An update on the distribution, bionomics, and insecticide susceptibility of Anopheles stephensi in Ethiopia, 2018–2020

June 16, 2021 - 12:55 -- Open Access
Meshesha Balkew, Peter Mumba, Seth Irish, et al.
Malaria Journal 2021 20:263, 9 June 2021

Anopheles stephensi, an invasive malaria vector, was first detected in Africa nearly 10 years ago. After the initial finding in Djibouti, it has subsequently been found in Ethiopia, Sudan and Somalia. To better inform policies and vector control decisions, it is important to understand the distribution, bionomics, insecticide susceptibility, and transmission potential of An. stephensi. These aspects were studied as part of routine entomological monitoring in Ethiopia between 2018 and 2020.

Remote sensing of environmental risk factors for malaria in different geographic contexts

June 16, 2021 - 09:50 -- Open Access
McMahon A, Mihretie A, Ahmed AA, Lake M, Awoke W, Wimberly MC
Int J Health Geogr. 2021 Jun 13;20(1):28

Despite global intervention efforts, malaria remains a major public health concern in many parts of the world. Understanding geographic variation in malaria patterns and their environmental determinants can support targeting of malaria control and development of elimination strategies.

NOT Open Access | Evaluation of the Residual Efficacy of Actellic300 CS in Simple Huts in Central Ethiopia

June 15, 2021 - 14:58 -- NOT Open Access
Dugassa S, Mekonnen S, Muthee PW, Peter R, Zinyengere D, Feyasa MB, Sievert K
J Med Entomol. 2021 Jun 9:tjab096

Indoor residual spraying (IRS) is one of the key vector control tools with a long history of use in the world. Ethiopia has set a goal to eliminate malaria from selected districts mainly by applying IRS and the distribution of long-lasting insecticidal nets. IRS is applied in low malaria transmission districts which are epidemic prone and in districts with high malaria transmission.

Older children are at increased risk of Plasmodium vivax in south-central Ethiopia: a cohort study

June 9, 2021 - 07:44 -- Open Access
Taye Gari, Tarekegn Solomon and Bernt Lindtjørn
Malaria Journal 2021 20:251, 6 June 2021

Better understanding of the distribution of Plasmodium vivax and its risk factors could be used to prevent and control malaria infection. Therefore, the aim of this study was to characterize the distribution and risk factors of P. vivax, and to compare them with Plasmodium falciparum occurrence in south-central Ethiopia.


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