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Nigeria

NOT Open Access | Ethnopharmacology-aided antiplasmodial evaluation of six selected plants used for malaria treatment in Nigeria

March 2, 2020 - 14:39 -- NOT Open Access
Author(s): 
Ezenyi IC, Verma V, Singh S, Okhale SE, Adzu B
Reference: 
J Ethnopharmacol. 2020 Feb 21:112694

Sub – Saharan Africa has a high malaria burden and Nigeria accounts for majority of malaria cases worldwide. The aim of this study was to evaluate selected plants extracts used against malaria in Nigeria for antiplasmodial activity.

Diagnosis of pneumonia and malaria in Nigerian hospitals: A prospective cohort study

February 24, 2020 - 14:21 -- Open Access
Author(s): 
Graham H, Bakare AA, Ayede AI, Oyewole OB, Gray A, Neal E, Qazi SA, Duke T, Falade AG
Reference: 
Pediatr Pulmonol. 2020 Feb 19

Pneumonia and malaria are the leading causes of global childhood mortality. We describe the clinical presentation of children diagnosed with pneumonia and/or malaria, and identify possible missed cases and diagnostic predictors.

Evaluation of malaria surveillance system in Kano State, Nigeria, 2013-2016

February 14, 2020 - 17:01 -- Open Access
Author(s): 
Visa TI, Ajumobi O, Bamgboye E, Ajayi I, Nguku P
Reference: 
Infect Dis Poverty. 2020 Feb 10; 9(1):15

Malaria surveillance system strengthening is essential in the progress towards malaria elimination. In Nigeria, more attention is being given to this recently as the country is striving towards achieving elimination. However, the surveillance system performance is fraught with challenges including poor data quality with varying magnitude by state. This study evaluated the operation of the Kano State malaria surveillance system and assessed its key attributes.

Not Open Access | "Dual-gene" malaria-resistance: Therapeutically-rational exchange (T-REX) of group-O sickle trait and group-O C-trait red blood cells can be evaluated in Benin and Nigeria

February 13, 2020 - 15:00 -- NOT Open Access
Author(s): 
Jajosky RP, Jajosky AN, Jajosky PG
Reference: 
Transfus Apher Sci. 2020 Jan 27:102733

Using indicators of disease severity, clinicians can predict which Plasmodium falciparum (Pf) malaria patients being treated with artesunate or quinine are likely to die despite these drugs. Effective "rescue adjuncts" are needed when drugs alone are inadequate. "Therapeutically-rational exchange" (T-REX) of special malaria-resistant red blood cells (RBCs) has been proposed to optimize adjunctive exchange transfusion.

Effect of group versus individual antenatal care on uptake of intermittent prophylactic treatment of malaria in pregnancy and related malaria outcomes in Nigeria and Kenya: analysis of data from a pragmatic cluster randomized trial

February 3, 2020 - 17:17 -- Open Access
Author(s): 
Lisa Noguchi, Lindsay Grenier, Oniyire Adetiloye, et al.
Reference: 
Malaria Journal 2020 19:51, 29 January 2020

Every year, malaria in pregnancy contributes to approximately 20% of stillbirths in sub-Saharan Africa and 10,000 maternal deaths globally. Most eligible pregnant women do not receive the minimum three recommended doses of intermittent preventive treatment with Sulfadoxine–pyrimethamine (IPTp-SP). The objective of this analysis was to determine whether women randomized to group antenatal care (G-ANC) versus standard antenatal care (ANC) differed in IPTp uptake and insecticide-treated nets (ITN) use.

Asymptomatic falciparum Malaria and its Effects on Type 2 Diabetes Mellitus Patients in Lagos, Nigeria

January 20, 2020 - 15:07 -- Open Access
Author(s): 
Udoh BE, Iwalokun BA, Etukumana E, Amoo J
Reference: 
Saudi J Med Med Sci. 2020 Jan-Apr; 8(1):32-40

Asymptomatic malaria (ASM) constitutes a reservoir of malaria parasites that sustain transmission and threaten elimination efforts. Studies have also shown a significant relation between insulin resistance and malaria infection. However, data on the clinical effects of ASM and its patterns of carriage among adult malaria patients is limited.

Genetic polymorphisms in malaria vaccine candidate Plasmodium falciparum reticulocyte-binding protein homologue-5 among populations in Lagos, Nigeria

January 7, 2020 - 15:09 -- Open Access
Author(s): 
Olusola Ajibaye, Akinniyi A. Osuntoki, Alfred Amambua-Ngwa, et al.
Reference: 
Malaria Journal 2020 19:6, 6 January 2020

Vaccines are the most reliable alternative to elicit sterile immunity against malaria but their development has been hindered by polymorphisms and strain-specificity in previously studied antigens. New vaccine candidates are therefore urgently needed. Highly conserved Plasmodium falciparum reticulocyte-binding protein homologue-5 (PfRH5) has been identified as a potential candidate for anti-disease vaccine development. PfRH5 is essential for erythrocyte invasion by merozoites and crucial for parasite survival. However, there is paucity of data on the extent of genetic variations on PfRH5 in field isolates of Plasmodium falciparum. This study described genetic polymorphisms at the high affinity binding polypeptides (HABPs) 36718, 36727, 36728 of PfRH5 in Nigerian isolates of P. falciparum. This study tested the hypothesis that only specific conserved B and T cell epitopes on PfRH5 HABPs are crucial for vaccine development.

Adherence to malaria rapid diagnostic test result among healthcare workers in Sokoto metropolis, Nigeria

January 6, 2020 - 16:29 -- Open Access
Author(s): 
Aliyu Mamman Na’uzo, Dahiru Tukur, Olufemi Ajumobi, et al.
Reference: 
Malaria Journal 2020 19:2, 2 January 2020

Presumptive diagnosis and prescription of anti-malarial medicines to malaria rapid diagnostic test (RDT)-negative patients is a common practice among health care workers (HCWs) in Nigeria. There is paucity of data on HCWs adherence to RDT result in Sokoto metropolis, Nigeria. The study was conducted to determine HCWs adherence to malaria test result and the influencing factors.

High cases of submicroscopic Plasmodium falciparum infections in a suburban population of Lagos, Nigeria

December 30, 2019 - 14:21 -- Open Access
Author(s): 
Florence A. Umunnakwe, Emmanuel T. Idowu, Olusola Ajibaye, Blessed Etoketim, Samuel Akindele, Aminat O. Shokunbi, Olubunmi A. Otubanjo, Gordon A. Awandare, Alfred Amambua-Ngwa and Kolapo M. Oyebola
Reference: 
Malaria Journal 2019 18:433,19 December 2019

Asymptomatic malaria parasites are significant sources of infections for onward malaria transmission. Conventional tools for malaria diagnosis such as microscopy and rapid diagnostic test kits (RDT) have relatively low sensitivity, hence the need for alternative tools for active screening of such low-density infections.

NOT Open Access | The efficacy of intermittent preventive therapy in the eradication of peripheral and placental parasitemia in a malaria-endemic environment, as seen in a tertiary hospital in Abuja, Nigeria

December 23, 2019 - 14:30 -- NOT Open Access
Author(s): 
Umemmuo MU, Agboghoroma CO, Iregbu KC
Reference: 
Int J Gynaecol Obstet. 2019 Dec 12.

To determine whether intermittent preventive therapy in pregnancy (IPTp) eradicates peripheral and placental malaria and improves birth weight.

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