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Nigeria

The fidelity of implementation of recommended care for children with malaria by community health workers in Nigeria

March 10, 2020 - 16:11 -- Open Access
Author(s): 
Adeoti O, Spiegelman D, Afonne C, Falade CO, Jegede AS, Oshiname FO, Gomes M, Ajayi IO
Reference: 
Implement Sci. 2020 Mar 4;15(1):13

In the context of task shifting, a promoted approach to healthcare delivery in resource-poor settings, trained community health workers (CHWs) have been shown to be effective in delivering quality care of malaria for febrile under-5 children. While their effectiveness has been documented, the fidelity of implementation (FOI) has not been adequately studied. By understanding and measuring whether an intervention has been performed with fidelity, researchers and practitioners gain a better understanding of how and why an intervention works, and the extent to which outcomes can be improved. The objective of this study was to assess the FOI of a recommended protocol for malaria care by CHWs in a resource-poor setting in Nigeria.

'Everybody in Nigeria is a doctor…': a qualitative study of stakeholder perspectives on lay diagnosis of malaria and pneumonia in Nigeria

March 2, 2020 - 15:41 -- Open Access
Author(s): 
Elimian KO, Myles PR, Phalkey R, Sadoh A, Pritchard C
Reference: 
Journal of Public Health, fdaa015

Lay diagnosis is a widely used diagnostic approach for home management of common illnesses in Nigeria. This study aimed to explore the perspectives of caregivers and healthcare professionals on lay diagnosis of childhood malaria and pneumonia. Aligned to this, the study sought to explore the feasibility of training caregivers in the Integrated Management of Childhood Illness (IMCI) guidelines for improved recognition and treatment of these diseases.

Evaluation of a capacity building intervention on malaria treatment for under-fives in rural health facilities in Niger State, Nigeria

March 2, 2020 - 14:52 -- Open Access
Author(s): 
Ayodele Jegede, Barbara Willey, Prudence Hamade, Fredrick Oshiname, Daniel Chandramohan, IkeOluwa Ajayi, Catherine Falade, Ebenezer Baba and Jayne Webster
Reference: 
Malaria Journal 2020 19:90, 24 February 2020

Despite the uptake of parasitological testing into policy and practice, appropriate prescription of anti-malarials and artemisinin-based combination therapy (ACT) in accordance with test results is variable. This study describes a National Malaria Control Programme-led capacity building intervention which was implemented in 10 States of Nigeria. Using the experience of Niger State, this study assessed the effect on malaria diagnosis and prescription practices among febrile under-fives in rural health facilities.

NOT Open Access | Ethnopharmacology-aided antiplasmodial evaluation of six selected plants used for malaria treatment in Nigeria

March 2, 2020 - 14:39 -- NOT Open Access
Author(s): 
Ezenyi IC, Verma V, Singh S, Okhale SE, Adzu B
Reference: 
J Ethnopharmacol. 2020 Feb 21:112694

Sub – Saharan Africa has a high malaria burden and Nigeria accounts for majority of malaria cases worldwide. The aim of this study was to evaluate selected plants extracts used against malaria in Nigeria for antiplasmodial activity.

Diagnosis of pneumonia and malaria in Nigerian hospitals: A prospective cohort study

February 24, 2020 - 14:21 -- Open Access
Author(s): 
Graham H, Bakare AA, Ayede AI, Oyewole OB, Gray A, Neal E, Qazi SA, Duke T, Falade AG
Reference: 
Pediatr Pulmonol. 2020 Feb 19

Pneumonia and malaria are the leading causes of global childhood mortality. We describe the clinical presentation of children diagnosed with pneumonia and/or malaria, and identify possible missed cases and diagnostic predictors.

Evaluation of malaria surveillance system in Kano State, Nigeria, 2013-2016

February 14, 2020 - 17:01 -- Open Access
Author(s): 
Visa TI, Ajumobi O, Bamgboye E, Ajayi I, Nguku P
Reference: 
Infect Dis Poverty. 2020 Feb 10; 9(1):15

Malaria surveillance system strengthening is essential in the progress towards malaria elimination. In Nigeria, more attention is being given to this recently as the country is striving towards achieving elimination. However, the surveillance system performance is fraught with challenges including poor data quality with varying magnitude by state. This study evaluated the operation of the Kano State malaria surveillance system and assessed its key attributes.

Not Open Access | "Dual-gene" malaria-resistance: Therapeutically-rational exchange (T-REX) of group-O sickle trait and group-O C-trait red blood cells can be evaluated in Benin and Nigeria

February 13, 2020 - 15:00 -- NOT Open Access
Author(s): 
Jajosky RP, Jajosky AN, Jajosky PG
Reference: 
Transfus Apher Sci. 2020 Jan 27:102733

Using indicators of disease severity, clinicians can predict which Plasmodium falciparum (Pf) malaria patients being treated with artesunate or quinine are likely to die despite these drugs. Effective "rescue adjuncts" are needed when drugs alone are inadequate. "Therapeutically-rational exchange" (T-REX) of special malaria-resistant red blood cells (RBCs) has been proposed to optimize adjunctive exchange transfusion.

Effect of group versus individual antenatal care on uptake of intermittent prophylactic treatment of malaria in pregnancy and related malaria outcomes in Nigeria and Kenya: analysis of data from a pragmatic cluster randomized trial

February 3, 2020 - 17:17 -- Open Access
Author(s): 
Lisa Noguchi, Lindsay Grenier, Oniyire Adetiloye, et al.
Reference: 
Malaria Journal 2020 19:51, 29 January 2020

Every year, malaria in pregnancy contributes to approximately 20% of stillbirths in sub-Saharan Africa and 10,000 maternal deaths globally. Most eligible pregnant women do not receive the minimum three recommended doses of intermittent preventive treatment with Sulfadoxine–pyrimethamine (IPTp-SP). The objective of this analysis was to determine whether women randomized to group antenatal care (G-ANC) versus standard antenatal care (ANC) differed in IPTp uptake and insecticide-treated nets (ITN) use.

Asymptomatic falciparum Malaria and its Effects on Type 2 Diabetes Mellitus Patients in Lagos, Nigeria

January 20, 2020 - 15:07 -- Open Access
Author(s): 
Udoh BE, Iwalokun BA, Etukumana E, Amoo J
Reference: 
Saudi J Med Med Sci. 2020 Jan-Apr; 8(1):32-40

Asymptomatic malaria (ASM) constitutes a reservoir of malaria parasites that sustain transmission and threaten elimination efforts. Studies have also shown a significant relation between insulin resistance and malaria infection. However, data on the clinical effects of ASM and its patterns of carriage among adult malaria patients is limited.

Genetic polymorphisms in malaria vaccine candidate Plasmodium falciparum reticulocyte-binding protein homologue-5 among populations in Lagos, Nigeria

January 7, 2020 - 15:09 -- Open Access
Author(s): 
Olusola Ajibaye, Akinniyi A. Osuntoki, Alfred Amambua-Ngwa, et al.
Reference: 
Malaria Journal 2020 19:6, 6 January 2020

Vaccines are the most reliable alternative to elicit sterile immunity against malaria but their development has been hindered by polymorphisms and strain-specificity in previously studied antigens. New vaccine candidates are therefore urgently needed. Highly conserved Plasmodium falciparum reticulocyte-binding protein homologue-5 (PfRH5) has been identified as a potential candidate for anti-disease vaccine development. PfRH5 is essential for erythrocyte invasion by merozoites and crucial for parasite survival. However, there is paucity of data on the extent of genetic variations on PfRH5 in field isolates of Plasmodium falciparum. This study described genetic polymorphisms at the high affinity binding polypeptides (HABPs) 36718, 36727, 36728 of PfRH5 in Nigerian isolates of P. falciparum. This study tested the hypothesis that only specific conserved B and T cell epitopes on PfRH5 HABPs are crucial for vaccine development.

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