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Nigeria

Evaluation of in vivo anti-malarial potential of omidun obtained from fermented maize in Ibadan, Nigeria

November 24, 2020 - 13:42 -- Open Access
Author(s): 
Favour O. Omeiza, George O. Ademowo and Funmilola A. Ayeni
Reference: 
Malaria Journal 2020 19:414, 19 November 2020

The menace of resistance to anti-malarial drugs is a great challenge to malaria control, necessitating the search for new anti-malarial agents. This search has led to the exploration of natural products for efficacy in malaria therapy. Omidun is the supernatant of fermenting maize (ogi) slurry that has been widely investigated and reported to possess several health benefits and it is used traditionally as solvent for preparing anti-malarial herbs. However, there is no information on the anti-malarial activity of omidun itself. This study was conducted to investigate the prophylactic, curative and suppressive anti-malarial potential of omidun.

Rural–urban variation in insecticide-treated net utilization among pregnant women: evidence from 2018 Nigeria Demographic and Health Survey

November 12, 2020 - 15:57 -- Open Access
Author(s): 
Edward Kwabena Ameyaw, Kenneth Setorwu Adde, Shadrach Dare and Sanni Yaya
Reference: 
Malaria Journal 2020 19:407, 11 November 2020

In 2018, Nigeria accounted for the highest prevalence of malaria worldwide. Pregnant women and children under five years bear the highest risk of malaria. Geographical factors affect utilization of insecticide-treated nets (ITN), yet existing literature have paid little attention to the rural–urban dimension of ITN utilization in Nigeria. This study aimed at investigating the rural–urban variation in ITN utilization among pregnant women in Nigeria using data from the 2018 Demographic and Health Survey.

Clients' satisfaction with preventive services for malaria during pregnancy in Anambra state, Nigeria

November 7, 2020 - 12:44 -- Open Access
Author(s): 
Obagha EC, Ajayi I, Abdullahi GA, Umeokonkwo CD
Reference: 
BMC Public Health. 2020 Nov 4;20(1):1660

Burden of Malaria in pregnancy (MIP) is still high despite availability of proven cost-effective interventions. Considerable progress has been made on improving antenatal attendance, but MIP preventive services utilization remains low. Factors responsible for this include dissatisfaction with the services provided. We assessed clients’ satisfaction with preventative services for malaria during pregnancy delivered at antenatal clinics (ANC) in Anambra State Nigeria.

Health systems readiness and quality of inpatient malaria case-management in Kano State, Nigeria

November 4, 2020 - 09:55 -- Open Access
Author(s): 
Abiodun A. Ojo, Kolawole Maxwell, Dejan Zurovac, et al.
Reference: 
Malaria Journal 2020 19:384, 30 October 2020

Nigeria was among the first African countries to adopt and implement change of treatment policy for severe malaria from quinine to artesunate. Seven years after the policy change health systems readiness and quality of inpatient malaria case-management practices were evaluated in Kano State of Nigeria.

Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria

October 31, 2020 - 09:24 -- Open Access
Author(s): 
Tola M, Ajibola O, Idowu ET, Omidiji O, Awolola ST, Amambua-Ngwa A.
Reference: 
BMC Res Notes. 2020 Oct 27;13(1):497

Nigeria bears 25% of global malaria burden despite concerted efforts towards its control and elimination. The emergence of drug resistance to first line drugs, artemisinin combination therapies (ACTs), indicates an urgent need for continuous molecular surveillance of drug resistance especially in high burden countries where drug interventions are heavily relied on. This study describes mutations in Plasmodium falciparum genes associated with drug resistance in malaria; Pfk13, Pfmdr1, PfATPase6 and Pfcrt in isolates obtained from 83 symptomatic malaria patients collected in August 2014, aged 1–61 years old from South-west Nigeria.

NOT Open Access | Asymptomatic Malaria Co-infection of HIV-infected Adults in Nigeria. Prevalence of and Impact on Cognition, Mood and Biomarkers of Systemic Inflammation

October 7, 2020 - 15:43 -- NOT Open Access
Author(s): 
Bharti AR, McCutchan JA, Umlauf A, Okwuegbuna OK, Letendre S, Cherner M, Burdo T, Jumare J, Williams K, Blattner W, Royal W
Reference: 
J Acquir Immune Defic Syndr. 2020 Oct 1

HIV and malaria are associated with immunological perturbations and neurocognitive disorders even when asymptomatic. However, the effect of asymptomatic malaria (AM) in HIV-infected adults on neurocognitive impairment (NCI) is not well understood. This study investigated the biomarkers of systemic inflammation and neurocognition in dually-infected Nigerian adults.

NOT Open Access | Depletion of cholesterol could be associated with modulation of progesterone but not other sex hormone levels during Plasmodium falciparum infection in humans: a cross-sectional study from Zaria, Nigeria

September 23, 2020 - 08:46 -- NOT Open Access
Author(s): 
Usman MA, Ibrahim MA, Salman AA, Sallau AB
Reference: 
Parasitol Res. 2020 Sep 20

In order for Plasmodium falciparum to grow and survive in its host, membrane biogenesis, fueled by host cholesterol, is essential for these processes. Consistent with this essential role, more insights into the cholesterol pathway would enhance the current understanding of the pathophysiology of malaria infection. To explore its broader potential, we conducted a cross-sectional study and assayed for the serum levels of cholesterol, vitamin D, progesterone, testosterone, estradiol and bile acid in both P. falciparum-infected patients and apparently healthy sex-matched participants.

NOT Open Access | Multilevel modelling of the risk of malaria among children aged under five years in Nigeria

September 22, 2020 - 10:31 -- NOT Open Access
Author(s): 
Oguoma VM, Anyasodor AE, Adeleye AO, Eneanya OA, Mbanefo EC
Reference: 
Trans R Soc Trop Med Hyg. 2020 Sep 18:traa096

Malaria is still a major cause of morbidity and mortality among children aged <5 y (U5s). This study assessed individual, household and community risk factors for malaria in Nigerian U5s.

Community Voice Matters: Lessons from Field Studies of Malaria

September 15, 2020 - 15:06 -- Open Access
Author(s): 
Aju-Ameh C
Reference: 
Am J Trop Med Hyg. 2020 Sep;103(3):945-946

I have always been curious about arthropods and the dis-eases they transmit to humans. Growing up in a malaria-endemic area (Benue, Nigeria) exposed my family members and me to the revulsions of malaria disease. Children were theworst hit.

Early warning climate indices for malaria and meningitis in tropical ecological zones

September 2, 2020 - 08:30 -- Open Access
Author(s): 
Ayanlade A, Nwayor IJ, Sergi C, Ayanlade OS, Di Carlo P, Jeje OD, Jegede MO
Reference: 
Sci Rep. 2020 Aug 31;10(1):14303.

This study aims at assessing the impacts of climate indices on the spatiotemporal distribution of malaria and meningitis in Nigeria. The primary focus of the research is to develop an Early Warning System (EWS) for assessing climate variability implications on malaria and meningitis spread in the study area. Both climate and health data were used in the study to determine the relationship between climate variability and the occurrence of malaria and meningitis. The assessment was based on variations in different ecological zones in Nigeria.

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