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Genetic diversity of plasmodium falciparum isolates in Minna, North Central Nigeria inferred by PCR genotyping of Merozoite surface protein 1 and 2

November 25, 2021 - 12:59 -- Open Access
Hadijah UY, Innocent OCJ, Abdulkadir A, Abolarinwa SO, Samuel ES, Chidiebere OA
Infect Genet Evol. 2021 Nov 17:105143

North Central Nigeria is one region in Nigeria with a significant incidence of malaria caused majorly by Plasmodium falciparum. This study utilizes the msp1 and msp2 genes of P. falciparum to examine its diversity and multiplicity of infection (MOI). Blood samples were collected from 247 children across selected healthcare facilities in Minna, from infants and children aged 6 months to 17 years.

Absence of Plasmodium falciparum artemisinin resistance gene mutations eleven years after the adoption of artemisinin-based combination therapy in Nigeria

November 20, 2021 - 14:24 -- Open Access
Moses Ikegbunam, Johnson A. Ojo, Kossiwa Kokou, Ugonna Morikwe, Chukwuemeka Nworu, Chibuzo Uba, Charles Esimone, Thirumalaisamy P. Velavan and Olusola Ojurongbe
Malaria Journal 2021 20:434, 10 November 2021

The occurrence of artemisinin resistance (ART)-associated polymorphism of Plasmodium falciparum K13-propeller (pfk13) gene before and after the introduction of artemisinin-based combination therapy (ACT) in two regions of Nigeria was investigated in this study. Regular surveillance is necessary to make a definite conclusion on the emergence and pattern of possible resistance to ART.

Incentivizing appropriate malaria case management in the private sector: a study protocol for two linked cluster randomized controlled trials to evaluate provider- and client-focused interventions in western Kenya and Lagos, Nigeria

October 30, 2021 - 13:15 -- Open Access
Woolsey AM, Simmons RA, O'Meara WP, et al.
Implement Sci. 2021 Jan 20;16(1):14

A large proportion of artemisinin-combination therapy (ACT) anti-malarial medicines is consumed by individuals that do not have malaria. The over-consumption of ACTs is largely driven by retail sales in high malaria-endemic countries to clients who have not received a confirmatory diagnosis. This study aims to target ACT sales to clients receiving a confirmatory diagnosis using malaria rapid diagnostic tests (mRDTs) at retail outlets in Kenya and Nigeria.

A cross-sectional study of the prevalence, density, and risk factors associated with malaria transmission in urban communities of Ibadan, Southwestern Nigeria

October 30, 2021 - 12:48 -- Open Access
Awosolu OB, Yahaya ZS, Farah Haziqah MT, Simon-Oke IA, Fakunle C
Heliyon. 2021 Jan 20;7(1):e05975

Malaria is a severe global public health challenge that causes significant morbidity and mortality worldwide, particularly in sub-Saharan Africa. This study was designed to determine the prevalence, parasite density, and risk factors associated with malaria infection transmission among residents of two urban communities of Ibadan, southwestern Nigeria.

What do malaria program officers want to learn? A survey of perspectives on a proposed malaria short course in Nigeria

October 2, 2021 - 13:15 -- Open Access
Ajumobi O, Afolabi RF, Adewole A, Balogun MS, Nguku P, Ajayi IO
PLoS One. 2021 Sep 29;16(9):e0257890

In disease control, the program officers are vital to the successful implementation of control strategies. However, poor knowledge of the disease and its control, staff attrition, and lack of intentional training for new staff can lead to under-performance and ineffectiveness of interventions. Thus, the Nigeria Field Epidemiology and Laboratory Training Program, in collaboration with National Malaria Elimination Program, planned a malaria short course (MSC) to strengthen the capacity of current program managers and incoming staff. To guide the development of the curriculum for the MSC, we conducted a needs assessment survey to ascertain the perceived usefulness of the MSC, the priority rating of MSC thematic domains and associated factors.

Knowledge, attitude, and practice of the National Guidelines for Diagnosis and Treatment of Malaria among medical doctors in Ebonyi state, Nigeria: A cross-sectional survey

September 25, 2021 - 11:57 -- Open Access
Omale UI
PLoS One. 2021 Sep 20;16(9):e0257600

The Guidelines for Diagnosis and Treatment of Malaria are meant to guide medical practitioners to enhance optimal management of patients suspected of having malaria which is vital to malarial control and elimination. Medical doctors have the main responsibility for treating patients with malaria so there was need to evaluate the extent to which the medical doctors in Ebonyi state, Nigeria, knew, viewed, and practiced the 2015 National Guidelines for Diagnosis and Treatment of Malaria.

Rural-urban dimensions of the perception of malaria severity and practice of malaria preventive measures: insight from the 2018 Nigeria Demographic and Health Survey

September 25, 2021 - 11:43 -- Open Access
Duodu PA, Dzomeku VM, Emerole CO, Agbadi P, Arthur-Holmes F, Nutor JJ
J Biosoc Sci. 2021 Sep 17:1-18

Morbidities and mortalities caused by malaria are still a serious issue in Nigeria, with the country accounting for 25% of malaria morbidities and 24% of malaria mortalities globally in 2018. Treated bed nets reduce the incidence of malaria, but not all Nigerians use them. This study aimed to examine the factors associated with treated bed net usage, including perceived severity of malaria, and the rural-urban differences in the relationship between socio-demographic factors and use of treated bed nets in Nigeria. The analytic sample size comprised 40,693 women aged 15-49 years.

NOT Open Access | Towards malaria control in Nigeria: implications of the malaria parasite rate and spleen rate among children living in a rural community in southwest Nigeria

September 1, 2021 - 16:19 -- NOT Open Access
Fatunla OAT, Olatunya OS, Ogundare EO, Fatunla TO, Oluwayemi IO, Oluwadiya KS, Oyelami OA
Trans R Soc Trop Med Hyg. 2021 Aug 30:trab131

The World Health Organization prioritizes malaria surveillance for accurate tracking of progress of intervention programmes. The malaria parasite rate (PR) and spleen rate (SR) are economical surveillance tools. There has been a global decline in the burden of malaria over the last decade, but most African countries, like Nigeria, have a slow rate of decline. There is a need for adequate malaria surveillance to guide malaria control strategies and policymaking.

NOT Open Access | Mutations in Pfcrt and Pfmdr1 genes of Plasmodium falciparum isolates from two sites in Northcentral and Southwest Nigeria

August 25, 2021 - 16:56 -- NOT Open Access
Agomo CO, Mishra N, Olukosi YA, Gupta R, Kamlesh K, Aina OO, Awolola ST
Infect Genet Evol. 2021 Aug 19:105042

The ability of malaria parasites to develop resistance to antimalarial drugs has made it necessary to continuously survey malaria parasite populations for resistance markers. Mutations in specific malaria parasite genes confer resistance to antimalarial drugs. The study compared mutations in Pfcrt and Pfmdr1 genes of P. falciparum from two ecologically different areas of Nigeria. Plasmodium falciparum dried blood spots collected from New Bussa (Northcentral Nigeria) and Ijede (Southwest Nigeria) were analysed by PCR-RFLP for Pfcrt, K76 T, Pfmdr1, N86Y and Y184F mutations.

Demand for malaria rapid diagnostic test, health care-seeking behaviour, and drug use among rural community members with fever or malaria-like illness in Ebonyi state, Nigeria: a cross-sectional household survey

August 25, 2021 - 16:43 -- Open Access
Omale UI, Oka OU, Okeke IM, Azuogu BN, Alo C, Madubueze UC, Eze II, Okeke KC, Utulu R, Akpan UE, Iloke CV, Nnubia AO, Ibemesi DO, Nnabu CR, Anene OC
BMC Health Serv Res. 2021 Aug 21;21(1):857

A good understanding of the demand for malaria rapid diagnostic test (MRDT), malaria health care-seeking behavior, and drug use among community members is crucial to malaria control efforts. The aim of this study was to assess the demand (use and/or request) for MRDT, health care-seeking behavior, and drug use, as well as associated factors, among rural community members (both children and adults) with fever or malaria-like illness in Ebonyi state, Nigeria.


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