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Nigeria

NOT Open Access | Depletion of cholesterol could be associated with modulation of progesterone but not other sex hormone levels during Plasmodium falciparum infection in humans: a cross-sectional study from Zaria, Nigeria

September 23, 2020 - 08:46 -- NOT Open Access
Author(s): 
Usman MA, Ibrahim MA, Salman AA, Sallau AB
Reference: 
Parasitol Res. 2020 Sep 20

In order for Plasmodium falciparum to grow and survive in its host, membrane biogenesis, fueled by host cholesterol, is essential for these processes. Consistent with this essential role, more insights into the cholesterol pathway would enhance the current understanding of the pathophysiology of malaria infection. To explore its broader potential, we conducted a cross-sectional study and assayed for the serum levels of cholesterol, vitamin D, progesterone, testosterone, estradiol and bile acid in both P. falciparum-infected patients and apparently healthy sex-matched participants.

NOT Open Access | Multilevel modelling of the risk of malaria among children aged under five years in Nigeria

September 22, 2020 - 10:31 -- NOT Open Access
Author(s): 
Oguoma VM, Anyasodor AE, Adeleye AO, Eneanya OA, Mbanefo EC
Reference: 
Trans R Soc Trop Med Hyg. 2020 Sep 18:traa096

Malaria is still a major cause of morbidity and mortality among children aged <5 y (U5s). This study assessed individual, household and community risk factors for malaria in Nigerian U5s.

Community Voice Matters: Lessons from Field Studies of Malaria

September 15, 2020 - 15:06 -- Open Access
Author(s): 
Aju-Ameh C
Reference: 
Am J Trop Med Hyg. 2020 Sep;103(3):945-946

I have always been curious about arthropods and the dis-eases they transmit to humans. Growing up in a malaria-endemic area (Benue, Nigeria) exposed my family members and me to the revulsions of malaria disease. Children were theworst hit.

Early warning climate indices for malaria and meningitis in tropical ecological zones

September 2, 2020 - 08:30 -- Open Access
Author(s): 
Ayanlade A, Nwayor IJ, Sergi C, Ayanlade OS, Di Carlo P, Jeje OD, Jegede MO
Reference: 
Sci Rep. 2020 Aug 31;10(1):14303.

This study aims at assessing the impacts of climate indices on the spatiotemporal distribution of malaria and meningitis in Nigeria. The primary focus of the research is to develop an Early Warning System (EWS) for assessing climate variability implications on malaria and meningitis spread in the study area. Both climate and health data were used in the study to determine the relationship between climate variability and the occurrence of malaria and meningitis. The assessment was based on variations in different ecological zones in Nigeria.

Investigating the molecular basis of multiple insecticide resistance in a major malaria vector Anopheles funestus (sensu stricto) from Akaka-Remo, Ogun State, Nigeria

August 19, 2020 - 16:09 -- Open Access
Author(s): 
Atoyebi SM, Tchigossou GM, Djouaka R, et al.
Reference: 
Parasit Vectors. 2020 Aug 18;13(1):423

Understanding the mechanisms used by Anopheles mosquitoes to survive insecticide exposure is key to manage existing insecticide resistance and develop more suitable insecticide-based malaria vector control interventions as well as other alternative integrated tools. To this regard, the molecular basis of permethrin, DDT and dieldrin resistance in Anopheles funestus (sensu stricto) at Akaka-Remo was investigated.

Rural–urban disparities and factors associated with delayed care-seeking and testing for malaria before medication use by mothers of under-five children, Igabi LGA, Kaduna Nigeria

August 19, 2020 - 09:30 -- Open Access
Author(s): 
Obafemi J. Babalola, Olufemi Ajumobi and IkeOluwapo O. Ajayi
Reference: 
Malaria Journal 2020 19:294, 18 August 2020

Fever in under-five children (U5) is the commonest presenting complaint in general practice and mothers’ recognition is an entry point for fever treatment, including malaria. This study describes rural–urban disparity in fever prevalence in U5, mothers’ malaria knowledge, care-seeking, testing for malaria before anti-malarial medication and the associated factors.

NOT Open Access | Analysis of sulphadoxine-pyrimethamine resistance-associated mutations in Plasmodium falciparum isolates obtained from asymptomatic pregnant women in Ogun State, Southwest Nigeria

August 19, 2020 - 09:17 -- NOT Open Access
Author(s): 
Fagbemi KA, Adebusuyi SA, Nderu D, Adedokun SA, Pallerla SR, Amoo AOJ, Thomas BN, Velavan TP, Ojurongbe O
Reference: 
Infect Genet Evol. 2020 Aug 14:104503

Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) is one of the main strategies for protecting pregnant women, fetus, and their new-born against adverse effects of P. falciparum infection. The development of the drug resistance linked to mutations in P. falciparum dihydrofolate reductase gene (pfdhfr) and P. falciparum dihydropteroate synthase gene (pfdhps), is currently threatening the IPTp-SP approach.

Stocking pattern for anti-malarial medications among proprietary patent medicine vendors in Akinyele Local Government Area, Ibadan, Nigeria

August 4, 2020 - 16:12 -- Open Access
Author(s): 
Mary Y. Kodaolu, Adeniyi F. Fagbamigbe and IkeOluwapo O. Ajayi
Reference: 
Malaria Journal 2020 19:279, 3 August 2020

Policymakers have recognized that proprietary patent medicine vendors (PPMVs) can provide an opportunity for effective scaling up of artemisinin-based combination therapy (ACT) since they constitute a major source of malaria treatment in Nigeria. This study was designed to determine the stocking pattern for anti-malarial medications, knowledge of the recommended anti-malarial medicine among PPMVs in Akinyele Local Government Area (LGA) of Oyo State, Nigeria and their perception on ways to improve PPMV adherence to stocking ACT medicines.

Is the malaria short course for program managers, a priority for malaria control effort in Nigeria? Evidence from a qualitative study

July 30, 2020 - 13:22 -- Open Access
Author(s): 
Ajayi IO, Ajumobi O, Ogunwale A, Adewole A, Odeyinka OT, Balogun MS, Nguku P, Bamiselu O
Reference: 
PLoS ONE 15(7): e0236576

A Malaria Short Course (MSC) was conceptualized to build the capacity of program managers for malaria control due to the lack of a single comprehensive broad-based programmatic training in Nigeria. Prior to its implementation, a needs assessment was conducted based on the perspectives of stakeholders to plan and develop the curriculum.

NOT Open Access | Comparing the accuracy of lay diagnosis of childhood malaria and pneumonia with that of the revised IMCI guidelines in Nigeria

July 20, 2020 - 15:08 -- NOT Open Access
Author(s): 
Elimian KO, Myles PR, Phalkey R, Sadoh A, Pritchard C
Reference: 
J Public Health (Oxf). 2020 Jul 15:fdaa103

Improving caregivers’ recognition of childhood malaria and pneumonia is crucial to early treatment and improving outcomes. The objective of this study was to assess the accuracy and reliability of caregivers’ recognition of malaria and pneumonia (lay diagnosis) as compared to the revised IMCI guidelines.

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