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plasmodium falciparum

Malaria risk factor assessment using active and passive surveillance data from Aceh Besar, Indonesia, a low endemic, malaria elimination setting with Plasmodium knowlesi, Plasmodium vivax, and Plasmodium falciparum

September 14, 2016 - 17:20 -- Open Access
Herdiana Herdiana, Chris Cotter, Michelle S. Hsiang, et al.
Malaria Journal 2016 15:468, 13 September 2016

In this setting, risk of malaria infection in index and RACD identified cases was associated with forest exposure, particularly overnights in the forest for work.

A redesigned CRISPR/Cas9 system for marker-free genome editing in Plasmodium falciparum

April 26, 2016 - 16:06 -- Open Access
Lu J, Tong Y, Pan J, Yang Y, Liu Q, Tan X, Zhao S, Qin L, Chen X
Parasites & Vectors 2016, 9 :198 (11 April 2016)

Nonetheless, whether this approach can mediate even the regular gene editing in Pf remains unknown. This study aimed to demonstrate the basic gene editing function of this Cas9-mediated suicide-rescue system.

Karyotypic assignment of Sri Lankan Anopheles culicifacies species B and E does not correlate with cytochrome oxidase subunit I and microsatellite genotypes

August 26, 2015 - 07:32 -- Open Access
Sinnathamby N. Surendran, Nathan Truelove, Devojit K. Sarma, Pavilupillai J. Jude, Ranjan Ramasamy, Kanapathy Gajapathy, Lalanthika B. S. Peiris, S. H. P. Parakrama Karunaratne and Catherine Walton
Parasites & Vectors 2015, 8:327

Detailed analysis with more microsatellite markers and assortative mating experiments are needed to establish the presence of the two genetically distinct populations and relate them to Y-chromosome morphology.

Exploring immunological mechanisms of the whole sporozoite vaccination against P. falciparum malaria

July 31, 2015 - 17:17 -- Open Access
Annie X.Y. Mo, John Pesce, B. Fenton Hall
Vaccine, Volume 33, Issue 25, 9 June 2015, Pages 2851-2857

The workshop discussed the current understanding of host immune responses to whole malaria sporozoite inoculation, identified gaps in knowledge, resources to facilitate progress, and applicable new technologies and approaches to accelerate immunologic and vaccinologic studies and biomarker identification. 

Multiple Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants per genome can bind IgM via Fcμ

July 31, 2015 - 16:08 -- Open Access
Anine Jeppesen, Sisse Bolm Ditlev, Vladyslav Soroka, Liz Stevenson, Louise Turner, Ron Dzikowski, Lars Hviid, and Lea Barfod
Infect. Immun

Our study provides new evidence regarding Fc-dependent binding of IgM to PfEMP1, which appears to be a common and multifunctional phenotype.

Targeting male mosquito mating behaviour for malaria control

July 9, 2015 - 15:39 -- Open Access
Diabate A, Tripet F
Parasites & Vectors 2015, 8 :347 (26 June 2015)

Here, we argue that recent and continuing progress in our understanding of male mating biology is instrumental in the implementation of new approaches based on the release of either conventional sterile or genetically engineered males. 

CD14 hi CD16+ monocytes phagocytose antibody-opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so

July 9, 2015 - 15:28 -- Open Access
Zhou J, Feng G, Beeson J, Hogarth P, Rogerson S, Yan Y, Jaworowski A
BMC Medicine 2015, 13 :154 (7 July 2015)

We show a special role for CD14 hi CD16+ monocytes in phagocytosing opsonised P. falciparum IE and production of TNF. While ingestion was mediated by Fcγ receptor IIIa, this receptor was not sufficient to allow phagocytosis; despite opsonisation with antibody, phagocytosis of IE also required complement opsonisation. 

NOT Open Access | Inhibition of Protein Synthesis and Malaria Parasite Development by Drug Targeting of Methionyl-tRNA Synthetases

March 15, 2015 - 20:25 -- NOT Open Access
Tahir Hussain, Manickam Yogavel, and Amit Sharma
Antimicrob. Agents Chemother. April 2015 vol. 59 no. 4 1856-1867

Aminoacyl-tRNA synthetases (aaRSs) are housekeeping enzymes that couple cognate tRNAs with amino acids to transmit genomic information for protein translation.

Avian malaria parasites in the last supper: identifying encounters between parasites and the invasive Asian mosquito tiger and native mosquito species in Italy

February 24, 2015 - 15:51 -- Open Access
Josué Martínez-de la Puente, Joaquín Muñoz, Gioia Capelli, Fabrizio Montarsi, Ramón Soriguer, Daniele Arnoldi, Annapaola Rizzoli, Jordi Figuerola
Malaria Journal 2015, 14:32 (28 January 2015)

These results are the first identifying the avian malaria parasites harboured by mosquitoes in Italy and represent the first evidence supporting that, although Ae. albopictus could be involved in the transmission of avian malaria parasites, the risk of avian malaria parasite spread by this invasive mosquito in Europe would be minimal.

Adherence to malaria prophylaxis among Peace Corps Volunteers in the Africa region, 2013

February 5, 2015 - 15:37 -- Open Access
Keren Z. Landman, Kathrine R. Tan, Paul M. Arguin
Travel Medicine and Infectious Disease, Volume 13, Issue 1, January–February 2015, Pages 61-68

We investigated Volunteers' knowledge, attitudes, and practices regarding prophylaxis using an internet-based survey during August 19–September 30, 2013. Adherence was defined as taking doxycycline or atovaquone–proguanil daily, or taking mefloquine doses no more than 8 days apart.



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