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malarial anemia

NOT Open Access | Increase hemoglobin level in severe malarial anemia while controlling parasitemia: A mathematical model

August 3, 2020 - 16:21 -- NOT Open Access
Author(s): 
Siewe N, Friedman A
Reference: 
Mathematical Biosciences Volume 326, August 2020, 108374

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by immune cells; it can play a protective or deleterious role in response to pathogens. The intracellular malaria parasite secretes a similar protein, PMIF. The present paper is concerned with severe malarial anemia (SMA), where MIF suppresses the recruitment of red blood cells (RBCs) from the spleen and the bone marrow.

Not Open Access | Plasmodium Products Contribute to Severe Malarial Anemia by Inhibiting Erythropoietin-Induced Proliferation of Erythroid Precursors

December 17, 2013 - 19:13 -- NOT Open Access
Author(s): 
Neeta Thawani, Mifong Tam, Marie-Josée Bellemare, D. Scott Bohle, Martin Olivier, J. Brian de Souza and Mary M. Stevenson
Reference: 
J Infect Dis. (2014) 209 (1): 140-149

To determine whether Hz contributes to malarial anemia, P. yoelii–derived or synthetic Hz was administered to naive mice, and the development of anemia, reticulocytosis, and RBC turnover was determined.

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