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plasmodium sporozoites

Antibody-Mediated Protection against Plasmodium Sporozoites Begins at the Dermal Inoculation Site

January 8, 2019 - 15:54 -- Open Access
Yevel Flores-Garcia, Gibran Nasir, Christine S. Hopp, Christian Munoz, Amanda E. Balaban, Fidel Zavala and Photini Sinnis
mBio November/December 2018 9:e02194-18

Plasmodium sporozoites are injected into the skin as mosquitoes probe for blood.

NOT Open Access | A novel nested polymerase chain reaction assay targeting Plasmodium mitochondrial DNA in field-collected Anopheles mosquitoes

August 7, 2018 - 15:54 -- NOT Open Access
M. Calzetta, E. Perugini, G. Seixas, C. A. Sousa, W. M. Guelbeogo, N. Sagnon, A. Della Torre, J. Pinto, M. Pombi and E. Mancini
Medical and Veterinary Entomology, Volume32, Issue3 September 2018 Pages 372-377

Sensitive techniques for the detection of Plasmodium (Aconoidasida: Plasmodiidae) sporozoites in field‐collected malaria vectors are essential for the correct assessment of risk for malaria transmission.

Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood

July 31, 2018 - 15:26 -- Open Access
Sean C. Murphy, Andrew S. Ishizuka, Robert A. Seder, et al.
Malaria Journal 2018 17:275, 27 July 2018

Beyond the first few hours after injection, sporozoite-derived Plasmodium 18S rRNA was not detected in peripheral blood.

NOT Open Access | Protective efficacy of an IL-12-expressing baculoviral malaria vaccine

November 30, 2017 - 14:48 -- NOT Open Access
M. Iyori, A. M. Blagborough, K. A. Sala, H. Nishiura, K. Takagi and S. Yoshida
Parasite Immunology, olume 39, Issue 12 December 2017, e12498

Interleukin-12 (IL-12) plays an important role in antigen-specific adaptive immunity against Plasmodium sporozoites, and this requirement allows for a new approach to developing an effective malaria vaccine.

The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites

July 23, 2016 - 17:56 -- Open Access
Kartik S. Bane, Simone Lepper, Friedrich Frischknecht, et al.
PLoS Pathog 12(7): e1005710

Parasites causing malaria need to migrate in order to penetrate tissue barriers and enter host cells.

Not Open Access: Purification of Plasmodium sporozoites enhances parasite-specific CD8+ T cell responses

May 26, 2016 - 16:31 -- NOT Open Access
Billman ZP, Seilie AM, Murphy SC
Infect Immun. 2016 May 23. pii: IAI.01439-15

In this study, large secondary doses of unpurified sporozoites unexpectedly led to contraction of sporozoite-specific CD8+ T cell responses in sporozoite-primed mice. While sporozoite-primed CD8+ T cells can alternatively be expanded by secondary exposure to Listeria monocytogenes expressing recombinant Plasmodium antigens, such expansion was potently inhibited by co-injection of large doses of unpurified sporozoites and by uninfected salivary glands alone. 

Not Open Access | Plasmodium sporozoites acquire virulence and immunogenicity during mosquito hemocoel transit

January 6, 2014 - 16:03 -- NOT Open Access
Yuko Sato, Georgina N. Montagna and Kai Matuschewski
Infection and Immunity , volume 82, issue 1, January 2014

In this study, we systematically compared infectivity of Plasmodium berghei sporozoites isolated from the mosquito hemocoel and salivary glands. Hemocoel sporozoites display a lower proportion of gliding motility, but develop into liver stages when added to cultured hepatoma cells or after intravenous injection into mice.

Not Open Access | Imaging mosquito transmission of Plasmodium sporozoites into the mammalian host: Immunological implications

November 28, 2013 - 14:39 -- NOT Open Access
Jerome P. Vanderberg
Parasitology International, Volume 63, Issue 1, February 2014, Pages 150-164

This review discusses the early history of imaging studies, and focuses on the role that imaging has played in enabling a better understanding of both the induction and effector functions of the immune responses against sporozoites.

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