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Strategies for malaria elimination: an Afro-Colombian perspective

November 19, 2020 - 13:00 -- Open Access
Knudson-Ospina A, Barreto-Zorza YM, Castillo CF, Y Mosquera L, Apráez-Ippolito G, Olaya-Másmela LA, Piamba AH, Sanchez R
Rev Salud Publica (Bogota). 2020 Nov 13;21(1):9-16

To describe strategies for malaria elimination based on the perception of Afro-Colombian residents in Guapi, in the context of the Integrated Management Strategy for the Promotion, Prevention and Control of Vector-Borne Diseases in Colombia (EGI-ETV).

Study design and operational framework for a community-based Malaria Elimination Demonstration Project (MEDP) in 1233 villages of district Mandla, Madhya Pradesh

November 17, 2020 - 13:20 -- Open Access
Harsh Rajvanshi, Praveen K. Bharti, Altaf A. Lal, et al.
Malaria Journal 2020 19:410, 16 November 2020

In the past decade substantial reduction in malaria morbidity and mortality has been observed through well-implemented case management and vector control strategies. India has also achieved a significant reduction in malaria burden in 2018 and has committed to eliminate malaria by 2030. The Mandla Malaria Elimination Demonstration Project (MEDP) was started in 2017 in 1233 villages of District Mandla to demonstrate malaria elimination in a tribal district with hard-to-reach areas was possible using active and passive surveillance, case management, vector control, and targeted information, education and communication campaigns. An operational plan was developed to strengthen the existing surveillance and malaria elimination systems, through fortnightly active case detection to ensure that all cases including those that are introduced into the communities are rapidly identified and treated promptly. The plan also focused on the reduction of human-mosquito contact through the use of Long-Lasting Insecticial Nets (LLINs) and Indoor Residual Spray (IRS). The operational plan was modified in view of the present COVID-19 pandemic by creating systems of assistance for the local administration for COVID-related work while ensuring the operational integrity of malaria elimination efforts.

Reactive Case Detection (RACD) and foci investigation strategies in malaria control and elimination: a review

November 11, 2020 - 14:25 -- Open Access
Ruwanthi Perera, Amandhi Caldera and A. Rajitha Wickremasinghe
Malaria Journal 2020 19:401, 10 November 2020

Reactive case detection (RACD) and foci investigation are key strategies in malaria elimination and prevention of its re-establishment. They are a key part of surveillance that has been recommended by the World Health Organization (WHO) to be considered as a core intervention and as one of the three pillars of the Global Technical Strategy for Malaria 2016–2030.

NOT Open Access | Spatial analysis of malaria in Kotabaru, South Kalimantan, Indonesia: an evaluation to guide elimination strategies

November 11, 2020 - 13:09 -- NOT Open Access
Juhairiyah J, Andiarsa D, Indriyati L, Ridha MR, Prasodjo RS, Dhewantara PW
Trans R Soc Trop Med Hyg. 2020 Nov 9:traa125

Malaria remains a significant public health concern in Indonesia. Knowledge about spatial patterns of the residual malaria hotspots is critical to help design elimination strategies in Kotabaru district, South Kalimantan, Indonesia.

The role of improved housing and living environments in malaria control and elimination

November 4, 2020 - 09:56 -- Open Access
Richard Carter and Nadira D. Karunaweera
Malaria Journal 2020 19:385, 31 October 2020

Malaria risk and endemicity is often associated with the nature of human habitation and living environment. The disappearance of malaria from regions where it had been endemic for centuries, such as coastal areas of southern England, has been attributed, at least in part, to improvement in the quality of housing. Moreover, indigenous malaria transmission ceased throughout England without the necessity to eliminate the vector mosquitoes.

The impact of COVID-19 pandemic on malaria elimination

October 31, 2020 - 09:28 -- Open Access
Zawawi A, Alghanmi M, Alsaady I, Gattan H, Zakai H, Couper K
Parasite Epidemiol Control. 2020 Oct 20:e00187

SARS-CoV-2 has spread throughout the world and become the cause of the infectious coronavirus disease 2019 (COVID-19). As low- and middle-income countries shift increasingly to focus on identifying and treating COVID-19, questions are emerging about the impact this shift in focus will have on ongoing efforts to control other infectious diseases, such as malaria.

Updates on malaria epidemiology and profile in Cabo Verde from 2010 to 2019: the goal of elimination

October 27, 2020 - 15:53 -- Open Access
Adilson José DePina, Gillian Stresman, Helga Sofia Baptista Barros, António Lima Moreira, Abdoulaye Kane Dia, Ullardina Domingos Furtado, Ousmane Faye, Ibrahima Seck and El Hadji Amadou Niang
Malaria Journal 2020 19:380, 23 October 2020

Located in West Africa, Cabo Verde is an archipelago consisting of nine inhabited islands. Malaria has been endemic since the settlement of the islands during the sixteenth century and is poised to achieve malaria elimination in January 2021. The aim of this research is to characterize the trends in malaria cases from 2010 to 2019 in Cabo Verde as the country transitions from endemic transmission to elimination and prevention of reintroduction phases.

Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria

October 13, 2020 - 12:48 -- Open Access
Dieng MM, Diawara A, Idaghdour Y, et al.
Nat Commun. 2020 Oct 9;11(1):5093

The mechanisms behind the ability of Plasmodium falciparum to evade host immune system are poorly understood and are a major roadblock in achieving malaria elimination. Here, we use integrative genomic profiling and a longitudinal pediatric cohort in Burkina Faso to demonstrate the role of post-transcriptional regulation in host immune response in malaria.

A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices

October 13, 2020 - 12:34 -- Open Access
Watson JA, Taylor AR, Ashley EA, Dondorp A, Buckee CO, White NJ, Holmes CC
PLoS Genet. 2020 Oct 9;16(10):e1009037

Genetic surveillance of malaria parasites supports malaria control programmes, treatment guidelines and elimination strategies. Surveillance studies often pose questions about malaria parasite ancestry (e.g. how antimalarial resistance has spread) and employ statistical methods that characterise parasite population structure. Many of the methods used to characterise structure are unsupervised machine learning algorithms which depend on a genetic distance matrix, notably principal coordinates analysis (PCoA) and hierarchical agglomerative clustering (HAC).

Malaria case management and elimination readiness in health facilities of five districts of Madagascar in 2018

October 6, 2020 - 12:42 -- Open Access
Anjoli Anand, Rachel Favero, Jean-Pierre Rakotovao, et al.
Malaria Journal 2020 19:351, 1 October 2020

Madagascar’s Malaria National Strategic Plan 2018–2022 calls for progressive malaria elimination beginning in low-incidence districts (< 1 case/1000 population). Optimizing access to prompt diagnosis and quality treatment and improving outbreak detection and response will be critical to success. A malaria elimination readiness assessment (MERA) was performed in health facilities (HFs) of selected districts targeted for malaria elimination.


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