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plasmodium spp

A foci cohort analysis to monitor successful and persistent foci under Thailand’s Malaria Elimination Strategy

March 3, 2021 - 15:43 -- Open Access
Prayuth Sudathip, Suravadee Kitchakarn, Jui A. Shah, Donal Bisanzio, Felicity Young, Deyer Gopinath, Niparueradee Pinyajeerapat, David Sintasath and Cheewanan Lertpiriyasuwat
Malaria Journal 2021 20:118, 27 February 2021

Thailand’s success in reducing malaria burden is built on the efficient “1-3-7” strategy applied to the surveillance system. The strategy is based on rapid case notification within 1 day, case investigation within 3 days, and targeted foci response to reduce the spread of Plasmodium spp. within 7 days. Autochthonous transmission is still occurring in the country, threatening the goal of reaching malaria-free status by 2024. This study aimed to assess the effectiveness of the 1-3-7 strategy and identify factors associated with presence of active foci.

The need for social group interventions to increase malaria rapid diagnostic test uptake in Nigeria

March 2, 2021 - 11:22 -- Open Access
Falade CO, Mokuolu OA
Lancet Glob Health. 2021 Mar;9(3):e231-e232

Correct diagnosis is key to appropriate treatment of any disease, whether infectious or otherwise, and is particularly pertinent for the diagnosis of malaria and, consequently, appropriate treatment.

NOT Open Access | Leveraging Peptaibol Biosynthetic Promiscuity for Next-Generation Antiplasmodial Therapeutics

February 11, 2021 - 09:29 -- NOT Open Access
Lee JW, Collins JE, Wendt KL, Chakrabarti D, Cichewicz RH
J Nat Prod. 2021 Feb 10

Malaria remains a worldwide threat, afflicting over 200 million people each year. The emergence of drug resistance against existing therapeutics threatens to destabilize global efforts aimed at controlling Plasmodium spp. parasites, which is expected to leave vast portions of humanity unprotected against the disease. To address this need, systematic testing of a fungal natural product extract library assembled through the University of Oklahoma Citizen Science Soil Collection Program has generated an initial set of bioactive extracts that exhibit potent antiplasmodial activity (EC50 < 0.30 μg/mL) and low levels of toxicity against human cells (less than 50% reduction in HepG2 growth at 25 μg/mL).

NOT Open Access | Harnessing liver-resident memory T cells for protection against malaria

January 31, 2021 - 15:51 -- NOT Open Access
Fernandez-Ruiz D, de Menezes MN, Holz LE, Ghilas S, Heath WR, Beattie L
Expert Rev Vaccines. 2021 Jan 27

Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted adaptive immunity to infection in peripheral organs. Harnessing TRM cells through vaccination hence promises unprecedented potential for protection against infection. A paramount example of this is malaria, a major infectious disease for which immunity through traditional vaccination strategies remains challenging. Liver TRM cells appear to be highly protective against malaria, and recent developments in our knowledge of the biology of these cells have defined promising, novel strategies for their induction.

Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

January 5, 2021 - 15:06 -- Open Access
Schureck MA, Darling JE, Merk A, Shao J, Daggupati G, Srinivasan P, Olinares PDB, Rout MP, Chait BT, Wollenberg K, Subramaniam S, Desai SA
Elife. 2021 Jan 4;10:e65282

Malaria parasites use the RhopH complex for erythrocyte invasion and channel-mediated nutrient uptake. As the member proteins are unique to Plasmodium spp., how they interact and traffic through subcellular sites to serve these essential functions is unknown. We show that RhopH is synthesized as a soluble complex of CLAG3, RhopH2, and RhopH3 with 1:1:1 stoichiometry.

Molecular detection and species identification of Plasmodium spp. infection in adults in the Democratic Republic of Congo: A population-based study

November 25, 2020 - 12:26 -- Open Access
Kiyonga Aimeé K, Lengu TB, Nsibu CN, Umesumbu SE, Ngoyi DM, Chen T
PLoS One. 2020 Nov 23;15(11):e0242713

In efforts to control malaria infection, the Democratic Republic of Congo has implemented several strategies. Studies assessing their efficiency mainly involved at-risk groups, especially children under five years of age. This study aimed to determine the prevalence and identify the risk factors associated with Plasmodium spp. infection.

NOT Open Access | The malaria metabolite HMBPP does not trigger erythrocyte terpene release

September 24, 2020 - 08:13 -- NOT Open Access
Miller JJ, Odom John A
ACS Infect Dis. 2020 Sep 23

Infection with malarial parasites renders hosts more mosquito attractive than their uninfected, healthy, counterparts. One volatile organic compound, α-pinene, is associated with <I>Plasmodium</i> spp. infection in multiple studies and is a known mosquito attractant.

Rapid activation of distinct members of multigene families in Plasmodium spp

July 7, 2020 - 13:09 -- Open Access
Omelianczyk RI, Loh HP, Chew M, Hoo R, Baumgarten S, Renia L, Chen J, Preiser PR
Commun Biol. 2020 Jul 3;3(1):351

The genomes of Plasmodium spp. encode a number of different multigene families that are thought to play a critical role for survival. However, with the exception of the P. falciparum var genes, very little is known about the biological roles of any of the other multigene families. Using the recently developed Selection Linked Integration method, we have been able to activate the expression of a single member of a multigene family of our choice in Plasmodium spp. from its endogenous promoter.

NOT Open Access | Discovery of metabolic alterations in the serum of patients infected with Plasmodium spp. by high-resolution metabolomics

January 6, 2020 - 15:54 -- NOT Open Access
Na J, Khan A, Kim JK, Wadood A, Choe YL, Walker DI, Jones DP, Lim CS, Park YH
Metabolomics volume 16, 9 (2019)

Despite the advances in diagnosis and treatment, malaria has still not been eradicated. Metabolic interactions between the host and Plasmodium may present novel targets for malaria control, but such interactions are yet to be deciphered. An exploration of metabolic interactions between humans and two Plasmodium species by high-resolution metabolomics may provide fundamental insights that can aid the development of a new strategy for the control of malaria.

Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites

March 6, 2019 - 13:24 -- Open Access
Michael J. Boucher and Ellen Yeh
mSphere January/February 2019 4:e00710-18

Malaria parasites (Plasmodium spp.) contain a nonphotosynthetic plastid organelle called the apicoplast, which houses essential metabolic pathways and is required throughout the parasite life cycle.


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