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plasmodium spp

Molecular detection and species identification of Plasmodium spp. infection in adults in the Democratic Republic of Congo: A population-based study

November 25, 2020 - 12:26 -- Open Access
Kiyonga Aimeé K, Lengu TB, Nsibu CN, Umesumbu SE, Ngoyi DM, Chen T
PLoS One. 2020 Nov 23;15(11):e0242713

In efforts to control malaria infection, the Democratic Republic of Congo has implemented several strategies. Studies assessing their efficiency mainly involved at-risk groups, especially children under five years of age. This study aimed to determine the prevalence and identify the risk factors associated with Plasmodium spp. infection.

NOT Open Access | The malaria metabolite HMBPP does not trigger erythrocyte terpene release

September 24, 2020 - 08:13 -- NOT Open Access
Miller JJ, Odom John A
ACS Infect Dis. 2020 Sep 23

Infection with malarial parasites renders hosts more mosquito attractive than their uninfected, healthy, counterparts. One volatile organic compound, α-pinene, is associated with <I>Plasmodium</i> spp. infection in multiple studies and is a known mosquito attractant.

Rapid activation of distinct members of multigene families in Plasmodium spp

July 7, 2020 - 13:09 -- Open Access
Omelianczyk RI, Loh HP, Chew M, Hoo R, Baumgarten S, Renia L, Chen J, Preiser PR
Commun Biol. 2020 Jul 3;3(1):351

The genomes of Plasmodium spp. encode a number of different multigene families that are thought to play a critical role for survival. However, with the exception of the P. falciparum var genes, very little is known about the biological roles of any of the other multigene families. Using the recently developed Selection Linked Integration method, we have been able to activate the expression of a single member of a multigene family of our choice in Plasmodium spp. from its endogenous promoter.

NOT Open Access | Discovery of metabolic alterations in the serum of patients infected with Plasmodium spp. by high-resolution metabolomics

January 6, 2020 - 15:54 -- NOT Open Access
Na J, Khan A, Kim JK, Wadood A, Choe YL, Walker DI, Jones DP, Lim CS, Park YH
Metabolomics volume 16, 9 (2019)

Despite the advances in diagnosis and treatment, malaria has still not been eradicated. Metabolic interactions between the host and Plasmodium may present novel targets for malaria control, but such interactions are yet to be deciphered. An exploration of metabolic interactions between humans and two Plasmodium species by high-resolution metabolomics may provide fundamental insights that can aid the development of a new strategy for the control of malaria.

Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites

March 6, 2019 - 13:24 -- Open Access
Michael J. Boucher and Ellen Yeh
mSphere January/February 2019 4:e00710-18

Malaria parasites (Plasmodium spp.) contain a nonphotosynthetic plastid organelle called the apicoplast, which houses essential metabolic pathways and is required throughout the parasite life cycle.

Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire

January 15, 2019 - 15:32 -- Open Access
Eveline Hürlimann, Clarisse A. Houngbedji, Richard B. Yapi, Prisca B. N’Dri, Kigbafori D. Silué, Mamadou Ouattara, Jürg Utzinger, Eliézer K. N’Goran, Giovanna Raso
PLoS Negl Trop Dis 13(1): e0007086

No exacerbation from co-infection with Plasmodium and helminths was observed, neither in participants aged 5–18 years nor in adults from the community-based studies.

Reassessment of asymptomatic carriers of Plasmodium spp. in an endemic area with a very low incidence of malaria in extra-Amazonian Brazil

November 14, 2017 - 15:46 -- Open Access
Filomena E. C. de Alencar, Rosely dos Santos Malafronte, Crispim Cerutti Jr., Lícia Natal Fernandes, Julyana Cerqueira Buery, Blima Fux, Helder Ricas Rezende and Angelica Espinosa Miranda
Malaria Journal 2017 16:452, 9 November 2017

The findings suggest that untreated dwellers from this extra-Amazonian region, who initially harbour malaria parasites, may become negative without ever developing apparent symptoms of the disease.

NOT Open Access | Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

July 25, 2017 - 15:31 -- NOT Open Access
Mats Wahlgren, Suchi Goel & Reetesh R. Akhouri
Nature Reviews Microbiology 15, 479–491 (2017)

Proliferation and differentiation inside erythrocytes are important steps in the life cycle of Plasmodium spp.

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

May 25, 2017 - 14:43 -- Open Access
Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, and Miguel Prudêncio
Antimicrob. Agents Chemother. June 2017 vol. 61 no. 6 e02699-16

The sporogonic stage of the life cycle of Plasmodium spp., the causative agents of malaria, occurs inside the parasite's mosquito vector, where a process of fertilization, meiosis, and mitotic divisions culminates in the generation of large numbers of mammalian-infective sporozoites.

Exo-erythrocytic development of avian malaria and related haemosporidian parasites

March 9, 2017 - 15:44 -- Open Access
Gediminas Valkiūnas and Tatjana A. Iezhova
Malaria Journal 2017 16:101, 3 March 2017

Recent molecular studies combined with histological research show that avian haemosporidians are more virulent than formerly believed.


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