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red blood cells

NOT Open Access | An Effective Convolutional Neural Network for Classifying Red Blood Cells in Malaria Diseases

May 13, 2020 - 14:42 -- NOT Open Access
Quan Q, Wang J, Liu L
Interdiscip Sci. 2020 May 11

Malaria is one of the epidemics that can cause human death. Accurate and rapid diagnosis of malaria is important for treatment. Due to the limited number of data and human factors, the prediction performance and reliability of traditional classification methods are often affected. In this study, we propose an efficient and novel classification network named Attentive Dense Circular Net (ADCN) which based on Convolutional Neural Networks (CNN).

The malaria parasite Plasmodium falciparum in red blood cells selectively takes up serum proteins that affect host pathogenicity

April 20, 2020 - 08:46 -- Open Access
Takahiro Tougan, Jyotheeswara R. Edula, Masayuki Morita, Eizo Takashima, Hajime Honma, Takafumi Tsuboi and Toshihiro Horii
Malaria Journal 2020 19:155, 15 April 2020

The malaria parasite Plasmodium falciparum is a protozoan that develops in red blood cells (RBCs) and requires various host factors. For its development in RBCs, nutrients not only from the RBC cytosol but also from the extracellular milieu must be acquired. Although the utilization of host nutrients by P. falciparum has been extensively analysed, only a few studies have reported its utilization of host serum proteins. Hence, the aim of the current study was to comprehensively identify host serum proteins taken up by P. falciparum parasites and to elucidate their role in pathogenesis.

NOT Open Access | Identification of essential exported Plasmodium falciparum protein kinases in malaria-infected red blood cells

March 6, 2020 - 09:06 -- NOT Open Access
Siddiqui G, Proellochs NI, Cooke BM
Br J Haematol Volume 188, Issue 5, March 2020

FIKK kinases in the human malaria parasite Plasmodium falciparum are attractive targets for new anti‐malaria drugs, as they have no orthologues in humans and have been linked to disease severity. Six FIKKs are known to be exported into red blood cells (RBCs) where they mediate dramatic structural and functional changes to RBCs that are central to pathogenesis. Eleven members of this family, which are predicted to be exported into infected RBCs (iRBCs), remain uncharacterised.

Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo

November 18, 2019 - 16:15 -- Open Access
Sergey Kapishnikov, Trine Staalsø, Yang Yang, Jiwoong Lee, Ana J. Pérez-Berná, Eva Pereiro, Yang Yang, Stephan Werner, Peter Guttmann, Leslie Leiserowitz, and Jens Als-Nielsen
PNAS November 12, 2019 116 (46) 22946-22952

The most widely used antimalarial drugs belong to the quinoline family. Their mode of action has not been characterized at the molecular level in vivo. We report the in vivo mode of action of a bromo analog of the drug chloroquine in rapidly frozen Plasmodium falciparum-infected red blood cells.

Medical Condition: 

Not Open Access | Stretching and relaxation of malaria-infected red blood cells

September 11, 2013 - 18:30 -- NOT Open Access
Ye T, Phan-Thien N, Khoo BC, Lim CT
Biophys J. 2013 Sep 3;105(5):1103-9

In this work, we developed two types of cell model, one with an included parasite, and the other without an included parasite. The former is a representation of real malaria-infected RBCs, in which the parasite is treated as a rigid body.

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