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red blood cells

NOT Open Access | Lysercell M enhances the detection of stage-specific Plasmodium-infected red blood cells in the automated hematology analyzer XN-31 prototype

October 14, 2020 - 12:38 -- NOT Open Access
Toya Y, Tougan T, Horii T, Uchihashi K
Parasitol Int. 2020 Oct 10:102206

The automated hematology analyzers XN-30 (for research) and XN-31 prototype (for diagnosis support) can easily and rapidly detect Plasmodium-infected red blood cells (iRBCs) and distinguish the developmental stages of the parasite in approximately 1 min. Two dedicated reagents, Lysercell M and Fluorocell M, are available with the analyzers.

Not Open Access | Flagging performance of Sysmex XN-10 haematology analyser for malaria detection

October 7, 2020 - 16:20 -- NOT Open Access
Dumas C, Tirard-Collet P, Mestrallet F, Girard S, Jallades L, Picot S, Bienvenu AL.
J Clin Pathol. 2020 Oct;73(10):676-677

The aim was to assess the flagging performance of Sysmex XN-10 haematology analyser for malaria detection through the parasitic red blood cell ('pRBC') alarm.

NOT Open Access | Sequential classification system for recognition of malaria infection using peripheral blood cell images

October 7, 2020 - 16:17 -- NOT Open Access
Molina A, Alférez S, Boldú L, Acevedo A, Rodellar J, Merino A
J Clin Pathol. 2020 Oct;73(10):665-670

Morphological recognition of red blood cells infected with malaria parasites is an important task in the laboratory practice. Nowadays, there is a lack of specific automated systems able to differentiate malaria with respect to other red blood cell inclusions. This study aims to develop a machine learning approach able to discriminate parasitised erythrocytes not only from normal, but also from other erythrocyte inclusions, such as Howell-Jolly and Pappenheimer bodies, basophilic stippling as well as platelets overlying red blood cells.

Phosphorylation of Rhoptry Protein RhopH3 Is Critical for Host Cell Invasion by the Malaria Parasite

October 7, 2020 - 15:56 -- Open Access
Ekka R, Gupta A, Bhatnagar S, Malhotra P, Sharma P
mBio. 2020 Oct 6;11(5):e00166-20.

Merozoites formed after asexual division of the malaria parasite invade the host red blood cells (RBCs), which is critical for initiating malaria infection. The process of invasion involves specialized organelles like micronemes and rhoptries that discharge key proteins involved in interaction with host RBC receptors. RhopH complex comprises at least three proteins, which include RhopH3.

Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia

September 24, 2020 - 08:15 -- Open Access
Xu G, van Bruggen R, Gros P, et al.
Cell Rep. 2020 Sep 22;32(12):108170

The replication cycle and pathogenesis of the Plasmodium malarial parasite involves rapid expansion in red blood cells (RBCs), and variants of certain RBC-specific proteins protect against malaria in humans. In RBCs, bisphosphoglycerate mutase (BPGM) acts as a key allosteric regulator of hemoglobin/oxyhemoglobin. We demonstrate here that a loss-of-function mutation in the murine Bpgm (BpgmL166P) gene confers protection against both Plasmodium-induced cerebral malaria and blood-stage malaria.

Placental Malaria

September 23, 2020 - 09:21 -- Open Access
Zakama AK, Ozarslan N, Gaw SL
Curr Trop Med Rep. 2020 Sep 16:1-10

Placental malaria is the primary mechanism through which malaria in pregnancy causes adverse perinatal outcomes. This review summarizes recent work on the significance, pathogenesis, diagnosis, and prevention of placental malaria.

Non-lethal Plasmodium yoelii infection drives complex patterns of Th2-type host immunity and mast cell-dependent bacteremia

September 23, 2020 - 09:09 -- Open Access
Céspedes N, Donnelly E, Garrison S, Haapanen L, Van De Water J, Luckhart S
Infect Immun. 2020 Sep 21:IAI.00427-20

Malaria strongly predisposes to bacteremia, which is associated with sequestration of parasitized red blood cells and increased gastrointestinal permeability. The mechanisms underlying this disruption are poorly understood. Here we evaluated the expression of factors associated with mast cell activation and malaria-associated bacteremia in a rodent model. C57BL/6J mice were infected with Plasmodium yoelii yoelli 17XNL and blood and tissues were collected over time to assay for circulating levels of bacterial 16S DNA, IgE, mast cell protease 1 (Mcpt-1) and Mcpt-4, Th1 and Th2 cytokines as well as patterns of ileal mastocytosis and intestinal permeability.

NOT Open Access | Extracellular Vesicles Derived from Plasmodium-infected and Non-infected Red Blood Cells as Targeted Drug Delivery Vehicles

July 14, 2020 - 15:36 -- NOT Open Access
Borgheti-Cardoso LN, Kooijmans SAA, Fernàndez-Busquets X, et al.
Int J Pharm. 2020 Jul 9:119627

Among several factors behind drug resistance evolution in malaria is the challenge of administering overall doses that are not toxic for the patient but that, locally, are sufficiently high to rapidly kill the parasites. Thus, a crucial antimalarial strategy is the development of drug delivery systems capable of targeting antimalarial compounds to Plasmodium with high specificity.

In silico analysis for factors affecting anti-malarial penetration into red blood cells

June 26, 2020 - 15:16 -- Open Access
Natapol Pornputtapong, Bovornpat Suriyapakorn, Anchisa Satayamapakorn, Kanidsorn Larpadisorn, Pariyachut Janviriyakul and Phisit Khemawoot
Malaria Journal 2020 19:215, 23 June 2020

Malaria is a parasitic disease that produces significant infection in red blood cells. The objective of this study is to investigate the relationships between factors affecting the penetration of currently available anti-malarials into red blood cells.

NOT Open Access | Therapeutically-Rational Exchange (T-REX) of Gerbich-Negative Red Blood Cells Can be Evaluated in Papua New Guinea as "a Rescue Adjunct" for Patients with Plasmodium falciparum Malaria

June 23, 2020 - 16:22 -- NOT Open Access
Jajosky RP, Jajosky AN, Jajosky PG
Ther Apher Dial. 2020 Jun 21q

“Conventional exchange transfusion” ‐ that delivers nondescript “standard issue” units of red blood cells (RBCs) ‐ is used worldwide to rescue dying Plasmodium falciparum (Pf ) malaria patients. Recently, exchanging special malaria‐resistant RBCs has been recommended to prevent random delivery of malaria‐susceptible RBCs that promote Pf infection.


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