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Treatment

Arterolane, a New Synthetic Trioxolane for Treatment of Uncomplicated Plasmodium falciparum Malaria: A Phase II, Multicenter, Randomized, Dose-Finding Clinical Trial

August 10, 2010 - 09:38 -- Kabogo Ndegwa
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Author(s): 
N Valecha, S Looareesuwan, A Martensson, SM Abdulla, S Krudsood, N Tangpukdee, S Mohanty, SK Mishra, PK Tyagi, SK Sharma, J Moehrle, A Gautam, A Roy, JK Paliwal, M Kothari, N Saha, AP Dash, A örkman
Reference: 
Clinical Infectious Diseases 2010;51:000–000

Arterolane at daily doses of 100 and 200 mg is a rapidly acting, effective, and safe synthetic antimalarial drug, which may potentially represent an alternative to artemisinin derivatives in antimalarial combination therapy.

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Open Access | Editorial Commentary: Risks and Benefits of Targeted Malaria Treatment Based on Rapid Diagnostic Test Results

August 6, 2010 - 12:54 -- Kabogo Ndegwa
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Author(s): 
Anders Björkman and Andreas Mårtensson
Reference: 
Clinical Infectious Diseases 1 September 2010, Vol. 51, No. 5: 512-514

In this issue of Clinical Infectious Diseases, d’Acremont et al [1] importantly address the clinical safety of withholding antimalarial treatment in febrile children who have a negative result for one of the newly developed rapid diagnostic tests (RDTs) for malaria.

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Fixed artesunate-amodiaquine combined pre-formulation study for the treatment of malaria

July 20, 2010 - 08:07 -- Kabogo Ndegwa
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Author(s): 
T Kauss, F Fawaz, M Guyot, AM Lagueny, I dos Santos, F Bonini, P Olliaro, A Caminiti, P Millet
Reference: 
International Journal of Pharmaceutics, Volume 395, Issues 1-2, 16 August 2010, Pages 198-204

Artemisinin-based combination therapies, including artesunate (AS) + amodiaquine (AQ), are the currently recommended first-line treatment of uncomplicated falciparum malaria. Fixed-dose co-formulations offer logistic and adherence advantages.

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Open Access | Improvements in access to malaria treatment in Tanzania following community, retail sector and health facility interventions - a user perspective

June 16, 2010 - 09:32 -- Kabogo Ndegwa
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Author(s): 
Alba S, Dillip A, Hetzel MW, Mayumana I, Mshana C, Makemba A, Alexander M, Obrist B, Schulze A, Kessy F, Mshinda H, Lengeler C
Reference: 
Malaria Journal 2010, 9:163 (15 June 2010)

An integrated approach aimed at improving understanding and treatment of malaria has led to tangible improvements in terms of people's actions for the treatment of malaria. However, progress was hindered by the low availability of the first-line treatment after the switch to ACT.

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Open Access | Improvements in access to malaria treatment in Tanzania after switch to artemisinin combination therapy and the introduction of accredited drug dispensing outlets - a provider perspective

June 16, 2010 - 09:24 -- Kabogo Ndegwa
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Author(s): 
Alba S, Hetzel MW, Goodman C, Dillip A, Liana J, Mshinda H, Lengeler C
Reference: 
Malaria Journal 2010, 9:164 (15 June 2010)

The public health and private retail sector are important complementary sources of treatment in rural Tanzania. Ensuring the availability of ALu in the private retail sector is important for its successful uptake.

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Informal payments for healthcare: Differences in expenditures from consumers and providers perspectives for treatment of malaria in Nigeria

May 18, 2010 - 12:22 -- Kabogo Ndegwa
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Author(s): 
Obinna Onwujekwe, Nkem Dike, Benjamin Uzochukwu, Ogochukwu Ezeoke
Reference: 
Health Policy, Volume 96, Issue 1, June 2010, Pages 72-79

The differences in malaria treatment expenditures from consumers’ and providers’ perspectives point to high levels of informal payments, which worsen the economic burden of the disease and may predispose to catastrophic health spending.

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