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Treatment

Open Access | The Potential Contribution of Mass Treatment to the Control of Plasmodium falciparum Malaria

May 30, 2011 - 08:51 -- Kabogo Ndegwa
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Author(s): 
Lucy C. Okell, Jamie T. Griffin, Immo Kleinschmidt, T. Déirdre Hollingsworth, Thomas S. Churcher, Michael J. White, Teun Bousema, Chris J. Drakeley, Azra C. Ghani
Reference: 
PLoS ONE 6(5): e20179

Mass treatment as a means to reducing P. falciparum malaria transmission was used during the first global malaria eradication campaign and is increasingly being considered for current control programmes.

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Open Access | Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity

April 20, 2011 - 12:17 -- Kabogo Ndegwa
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Author(s): 
Serigne O Sarr, Sylvie Perrotey, Ibrahima Fall, Said Ennahar, Minjie Zhao, Yerim M Diop, Ermanno Candolfi, Eric Marchioni
Reference: 
Malaria Journal 2011, 10:85 (11 April 2011)

Anti-plasmodial activity and toxicity of I. senegalensis are reported for the first time and showed promising results in malaria field research.

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Open Access | Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria

April 20, 2011 - 09:55 -- Kabogo Ndegwa
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Author(s): 
Christy AN Okoromah, Bosede B Afolabi, Emma CB Wall
Reference: 
Cochrane Infectious Diseases Group

One trial met the inclusion criteria, comparing mannitol 20% to saline placebo in 156 Ugandan children. Allocation was concealed.

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Open Access | Cost-Effectiveness of Intermittent Preventive Treatment of Malaria in Pregnancy in Southern Mozambique

October 22, 2010 - 10:12 -- Kabogo Ndegwa
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Author(s): 
Elisa Sicuri, Azucena Bardají, Tacilta Nhampossa, Maria Maixenchs, Ariel Nhacolo, Delino Nhalungo, Pedro L. Alonso, Clara Menéndez
Reference: 
PLoS ONE 5(10): e13407

IPTp-SP was highly cost-effective for both prevention of maternal malaria and reduction of neonatal mortality in Mozambique. These findings are likely to hold for other settings where IPTp-SP is implemented through ANC visits.

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Open Access | The quest for universal access to effective malaria treatment: how can the AMFm contribute?

October 13, 2010 - 09:24 -- Kabogo Ndegwa
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Author(s): 
Matowe L, Adeyi O
Reference: 
Malaria Journal 2010, 9:274 (8 October 2010)

Access to quality assured artemisinin-based combination therapy (ACT) has remained very low in most malaria endemic countries. A number of reasons, including unaffordable prices, have contributed to the low accessibility to these life-saving medicines.

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Spiroindolones, a Potent Compound Class for the Treatment of Malaria

September 8, 2010 - 09:10 -- Kabogo Ndegwa
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Author(s): 
M Rottmann, C McNamara, TT Diagana, et al
Reference: 
Science 3 September 2010, Vol. 329. no. 5996, pp. 1175 – 1180

Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments.

Open Access | Antimalarial Exposure Delays Plasmodium falciparum Intra-Erythrocytic Cycle and Drives Drug Transporter Genes Expression

August 26, 2010 - 14:37 -- Kabogo Ndegwa
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Author(s): 
Maria Isabel Veiga, Pedro Eduardo Ferreira, Berit Aydin Schmidt, Ulf Ribacke, Anders Björkman, Ales Tichopad, José Pedro Gil
Reference: 
PLoS ONE 5(8): e12408

Both cell cycle delay and induced gene expression represent potentially important mechanisms for parasites to escape the effect of the antimalarial drug.

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Open Access | Arm-in-cage testing of natural human-derived mosquito repellents

August 23, 2010 - 13:21 -- Kabogo Ndegwa
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Author(s): 
Logan JG, Stanczyk NM, Hassanali A, Kemei J, Santana AE, Ribeiro KA, Pickett JA, Mordue (Luntz) A
Reference: 
Malaria Journal 2010, 9:239 (20 August 2010)

The optimum mixture of 6-methyl-5-hepten-2-one and geranylacetone was a 1:1 ratio and this provided the most effective protection against all species of mosquito tested. With further improvements in formulation, selected blends of these compounds have the potential to be exploited and developed as human-derived novel repellents for personal protection.

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Open Access | Application of mobile-technology for disease and treatment monitoring of malaria in the "Better Border Healthcare Programme"

August 20, 2010 - 13:55 -- Kabogo Ndegwa
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Author(s): 
Meankaew P, Kaewkungwal J, Khamsiriwatchara A, Khunthong P, Singhasivanon P, Satimai W
Reference: 
Malaria Journal 2010, 9:237 (19 August 2010)

The module was successfully integrated and functioned as part of the malaria prevention and control programme.

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Open Access | Artemisone effective against murine cerebral malaria

August 11, 2010 - 12:34 -- Kabogo Ndegwa
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Author(s): 
Waknine-Grinberg JH, Hunt N, Bentura-Marciano A, McQuillan JA, Chan H, Chan W, Barenholz Y, Haynes RK, Golenser J
Reference: 
Malaria Journal 2010, 9:227 (9 August 2010)

Altogether, the results support the use of artemisone for combined therapy of CM.

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