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plasmodium malariae

Two cases of long-lasting, sub-microscopic Plasmodium malariae infections in adults from coastal Tanzania

May 3, 2019 - 17:18 -- Open Access
Author(s): 
Tobias Schindler, Said Jongo, Claudia Daubenberger, et al.
Reference: 
Malaria Journal 2019 18:149, 29 April 2019

Background

Malaria is endemic in Tanzania with majority of clinical cases caused by Plasmodium falciparum. Additionally, Plasmodium malariae and Plasmodium ovale spp. are also present and clinical manifestations caused by these infections are not well described. Clinical episodes caused by P. malariae infections are often characterized by a relatively mild illness with a low number of parasites, which can persist for long periods. In this report, two cases of P. malariae infections that were identified during a clinical trial evaluating the P. falciparum malaria vaccine candidate, PfSPZ Vaccine are described. The two participants were followed up and monitored for clinical and laboratory parameters to assess vaccine safety providing the opportunity to study clinical manifestations of P. malariae over 4 months.

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Specificity of the IgG antibody response to Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale MSP119 subunit proteins in multiplexed serologic assays

November 15, 2018 - 15:07 -- Open Access
Author(s): 
Jeffrey W. Priest, Mateusz M. Plucinski, Curtis S. Huber, Eric Rogier, Bunsoth Mao, Christopher J. Gregory, Baltazar Candrinho, James Colborn and John W. Barnwell
Reference: 
Malaria Journal 2018 17:417

A pan-malaria MSP119 cross-reactive antibody response was observed in elutions of blood spots from two 20–30 years old Mozambique donors. The antibody response from one of these two donors had low avidity and skewed almost entirely to the IgG3 subclass.

NOT Open Access | Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon

February 28, 2018 - 14:41 -- NOT Open Access
Author(s): 
Mirjam Groger, Luzia Veletzky, Michael Ramharter, et al.
Reference: 
Antimicrob. Agents Chemother. March 2018 62:e01758-17

Treatment recommendations for Plasmodium malariae and Plasmodium ovale malaria are largely based on anecdotal evidence.

Genetic diversity of three surface protein genes in Plasmodium malariae from three Asian countries

January 16, 2018 - 15:49 -- Open Access
Author(s): 
Suttipat Srisutham, Naowarat Saralamba, Mallika Imwong, et al.
Reference: 
Malaria Journal 2018 17:24, 11 January 2018

High mutational diversity was observed in P. malariae trap and ama1 as compared to p48/45 in P. malariae samples isolated from Thailand, Myanmar, and Lao PDR.

Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic

August 19, 2017 - 16:00 -- Open Access
Author(s): 
Cynthia Bichara, Philippe Flahaut, Damien Costa, Anne-Lise Bienvenu, Stephane Picot and Gilles Gargala
Reference: 
Malaria Journal 2017 16:339, 15 August 2017

Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-infection and a delayed appearance of one cryptic species following treatment.

Plasmodium malariae in the Colombian Amazon region: you don’t diagnose what you don’t suspect

November 30, 2016 - 17:30 -- Open Access
Author(s): 
Carlos Hernando Niño, Juan Ricardo Cubides, Manuel Alfonso Patarroyo, et al.
Reference: 
Malaria Journal 2016 15:576, 29 November 2016

The present study revealed great differences between both diagnostic tests, as well as suggesting high P. malariae prevalence from a molecular perspective.

Low prevalence of Plasmodium malariae and Plasmodium ovale mono-infections among children in the Democratic Republic of the Congo: a population-based, cross-sectional study

July 12, 2016 - 17:09 -- Open Access
Author(s): 
Stephanie M. Doctor, Yunhao Liu, Steven R. Meshnick, et al.
Reference: 
Malaria Journal 2016 15:350, 8 July 2016

Plasmodium malariae and P. ovale remain endemic at a low rate in the DRC, but the risk of missing malarial infections of these species due to falciparum-specific RDT use is low.

Medical Treatment: 

Entomological aspects and the role of human behaviour in malaria transmission in a highland region of the Republic of Yemen

March 2, 2016 - 17:29 -- Open Access
Author(s): 
Samira M. A. Al-Eryani, Louise Kelly-Hope, Ralph E. Harbach, Andrew G. Briscoe, Guy Barnish, Ahmed Azazy and Philip J. McCall
Reference: 
Malaria Journal 2016 15:130, 1 March 2016

The predominantly indoor human biting vectors recorded in this study could be targeted effectively with LLINs, indoor residual spraying and/or insecticide-treated window/door curtains reinforced by education to instil a perception that effective and affordable malaria prevention is achievable.

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Medical Treatment: 

Plasmodium malariae Infection Associated with a High Burden of Anemia: A Hospital-Based Surveillance Study

January 20, 2016 - 15:25 -- Open Access
Author(s): 
Siobhan Langford, Nicholas M. Douglas, Daniel A. Lampah, Julie A. Simpson, Enny Kenangalem, Paulus Sugiarto, Nicholas M. Anstey, Jeanne Rini Poespoprodjo, Ric N. Price
Reference: 
PLoS Negl Trop Dis 9(12): e0004195

Plasmodium malariae infection is relatively uncommon in Papua, Indonesia but is associated with significant morbidity from anemia and a similar risk of mortality to patients hospitalized with P. falciparum and P. vivax infection.

Merozoite surface protein-1 genetic diversity in Plasmodium malariae and Plasmodium brasilianum from Brazil

November 23, 2015 - 15:39 -- Open Access
Author(s): 
Guimarães L, Wunderlich G, Kirchgatter K, et al.
Reference: 
BMC Infectious Diseases 2015, 15 :529 (16 November 2015)

Our data show that there is a low level of sequence diversity and a possible absence of allelic dimorphism of MSP1 in these parasites as opposed to other Plasmodium species. P. brasilianum strains apparently show greater divergence in comparison to P. malariae, thus P. malariae could derive from P. brasilianum, as it has been proposed.

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