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plasmodium malariae

NOT Open Access | Experimental transmission of Plasmodium malariae to Anopheles gambiae

July 7, 2020 - 13:12 -- NOT Open Access
Pinilla YT, Boussougou-Sambe ST, Gräßle S, Ngossanga B, Doumba-Ndalembouly AG, Weierich A, Bingoulou G, Malinga EG, Nguiffo D, Ntoumi F, Djogbénou L, Issifou S, Wondji CS, Adegnika AA, Borrmann S, COMAL Study Group
J Infect Dis. 2020 Jul 4:jiaa382

Our current knowledge of the clinical burden, biology, and transmission of Plasmodium malariae is extremely scarce. To start addressing some of those questions, we experimentally infected Anopheles gambiae mosquitoes with fresh P. malariae isolates obtained from asymptomatic individuals in Lambaréné, Gabon.

Genome-wide microsatellite characteristics of five human Plasmodium species, focusing on Plasmodium malariae and P. ovale curtisi

May 19, 2020 - 14:47 -- Open Access
Mathema VB, Nakeesathit S, White NJ, Dondorp AM, Imwong M
Parasite, Volume 27, 2020

Microsatellites can be utilized to explore genotypes, population structure, and other genomic features of eukaryotes. Systematic characterization of microsatellites has not been a focus for several species of Plasmodium, including P. malariae and P. ovale, as the majority of malaria elimination programs are focused on P. falciparum and to a lesser extent P. vivax. Here, five human malaria species (P. falciparum, P. vivax, P. malariae, P. ovale curtisi, and P. knowlesi) were investigated with the aim of conducting in-depth categorization of microsatellites for P. malariae and P. ovale curtisi.

An Experimental Human Blood-Stage Model for Studying Plasmodium malariae Infection

March 9, 2020 - 13:35 -- Open Access
Woodford J, Collins KA, Odedra A, Wang C, Jang IK, Domingo GJ, Watts R, Marquart L, Berriman M, Otto TD, McCarthy JS
The Journal of Infectious Diseases, Volume 221, Issue 6, 15 March 2020, Pages 948–955

Plasmodium malariae is considered a minor malaria parasite, although its global disease burden is underappreciated. The aim of this study was to develop an induced blood-stage malaria (IBSM) model of P. malariae to study parasite biology, diagnostic assays, and treatment.

NOT Open Access | A new Real Time PCR with species-specific primers from Plasmodium malariae/P. brasilianum mitochondrial cytochrome b gene

February 16, 2020 - 09:16 -- NOT Open Access
Dos Santos EH, Yamamoto L, Domingues W, di Santi SM, Kanunfre KA, Okay TS
Parasitology International, 2020 Feb 4:102069

Plasmodium malariae mainly causes asymptomatic submicroscopic parasitemia in the endemic Amazon and non-endemic Atlantic Forest, where the number of cases and transmission of malaria through blood transfusion has increased. This study developed a P. malariae/P. brasilianum Real Time PCR (rtPCR) targeting the cytochrome b oxidase (cytb), a highly repetitive gene (20–150 copies/parasite) that should detect more cases than the 18S rRNA (4–8 copies/parasite) gene-based amplification systems. Cytb from human and non-human Plasmodium species (including P. brasilianum) aligned to the only 20 African P. malariae cytb sequences identified polymorphic regions within which we designed P. malariae species-specific primers.

Polymorphic markers for identification of parasite population in Plasmodium malariae

February 3, 2020 - 17:03 -- Open Access
Vivek Bhakta Mathema, Supatchara Nakeesathit, Watcharee Pagornrat, Frank Smithuis, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong
Malaria Journal 2020 19:48, 28 January 2020

Molecular genotyping in Plasmodium serves many aims including providing tools for studying parasite population genetics and distinguishing recrudescence from reinfection. Microsatellite typing, insertion-deletion (INDEL) and single nucleotide polymorphisms is used for genotyping, but only limited information is available for Plasmodium malariae, an important human malaria species. This study aimed to provide a set of genetic markers to facilitate the study of P. malariae population genetics.

Two cases of long-lasting, sub-microscopic Plasmodium malariae infections in adults from coastal Tanzania

May 3, 2019 - 17:18 -- Open Access
Tobias Schindler, Said Jongo, Claudia Daubenberger, et al.
Malaria Journal 2019 18:149, 29 April 2019


Malaria is endemic in Tanzania with majority of clinical cases caused by Plasmodium falciparum. Additionally, Plasmodium malariae and Plasmodium ovale spp. are also present and clinical manifestations caused by these infections are not well described. Clinical episodes caused by P. malariae infections are often characterized by a relatively mild illness with a low number of parasites, which can persist for long periods. In this report, two cases of P. malariae infections that were identified during a clinical trial evaluating the P. falciparum malaria vaccine candidate, PfSPZ Vaccine are described. The two participants were followed up and monitored for clinical and laboratory parameters to assess vaccine safety providing the opportunity to study clinical manifestations of P. malariae over 4 months.


Specificity of the IgG antibody response to Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale MSP119 subunit proteins in multiplexed serologic assays

November 15, 2018 - 15:07 -- Open Access
Jeffrey W. Priest, Mateusz M. Plucinski, Curtis S. Huber, Eric Rogier, Bunsoth Mao, Christopher J. Gregory, Baltazar Candrinho, James Colborn and John W. Barnwell
Malaria Journal 2018 17:417

A pan-malaria MSP119 cross-reactive antibody response was observed in elutions of blood spots from two 20–30 years old Mozambique donors. The antibody response from one of these two donors had low avidity and skewed almost entirely to the IgG3 subclass.

NOT Open Access | Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon

February 28, 2018 - 14:41 -- NOT Open Access
Mirjam Groger, Luzia Veletzky, Michael Ramharter, et al.
Antimicrob. Agents Chemother. March 2018 62:e01758-17

Treatment recommendations for Plasmodium malariae and Plasmodium ovale malaria are largely based on anecdotal evidence.

Genetic diversity of three surface protein genes in Plasmodium malariae from three Asian countries

January 16, 2018 - 15:49 -- Open Access
Suttipat Srisutham, Naowarat Saralamba, Mallika Imwong, et al.
Malaria Journal 2018 17:24, 11 January 2018

High mutational diversity was observed in P. malariae trap and ama1 as compared to p48/45 in P. malariae samples isolated from Thailand, Myanmar, and Lao PDR.

Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic

August 19, 2017 - 16:00 -- Open Access
Cynthia Bichara, Philippe Flahaut, Damien Costa, Anne-Lise Bienvenu, Stephane Picot and Gilles Gargala
Malaria Journal 2017 16:339, 15 August 2017

Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-infection and a delayed appearance of one cryptic species following treatment.


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