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Treatment

Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis

August 3, 2020 - 16:31 -- Open Access
Author(s): 
Saito M, Mansoor R, Kennon K, Guérin PJ, et al.
Reference: 
Lancet Infect Dis. 2020 Aug;20(8):943-952

Malaria in pregnancy affects both the mother and the fetus. However, evidence supporting treatment guidelines for uncomplicated (including asymptomatic) falciparum malaria in pregnant women is scarce and assessed in varied ways. We did a systematic literature review and individual patient data (IPD) meta-analysis to compare the efficacy and tolerability of different artemisinin-based or quinine-based treatments for malaria in pregnant women.

Predictors of health workers’ knowledge about artesunate-based severe malaria treatment recommendations in government and faith-based hospitals in Kenya

July 29, 2020 - 10:11 -- Open Access
Author(s): 
Beatrice Machini, Dejan Zurovac, Beatrice Amboko, Lucas Malla, Robert W. Snow, Hillary Kipruto & Thomas N. O. Achia
Reference: 
Malaria Journal 2020 19:267, 23 July 2020

Health workers’ knowledge deficiencies about artesunate-based severe malaria treatment recommendations have been reported. However, predictors of the treatment knowledge have not been examined. In this paper, predictors of artesunate-based treatment knowledge among inpatient health workers in two hospital sectors in Kenya are reported.

Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia

July 14, 2020 - 09:17 -- Open Access
Author(s): 
Abdulhakim Abamecha, Daniel Yilma, Wondimagegn Addisu, Hassan El-Abid, Achim Ibenthal, Harald Noedl, Delenasaw Yewhalaw, Mohieddine Moumni and Alemseged Abdissa
Reference: 
Malaria Journal 2020 19:240, 10 July 2020

The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. Regular monitoring of drug efficacy is an important tool for supporting national treatment policies and practice. This study investigated the therapeutic efficacy of AL for the treatment of P. falciparum malaria in Ethiopia.

Digging for care-seeking behaviour among gold miners in the Guyana hinterland: a qualitative doer non-doer analysis of social and behavioural motivations for malaria testing and treatment

July 7, 2020 - 13:55 -- Open Access
Author(s): 
Shirley D. Yan, Jennifer Orkis, Saifra Khan Sohail, Sean Wilson, TrishAnn Davis and J. Douglas Storey
Reference: 
Malaria Journal 2020 19:235, 6 July 2020

Although Guyana has made significant progress toward malaria control, limited access to malaria testing and treatment services threatens those gains. Mining activities create breeding environments for mosquitoes, and the migrant and mobile mining populations are hard to reach with information and services. The Ministry of Public Health (MoPH) has trained volunteers to test and treat malaria cases in remote regions. However, it remains unclear how miners perceive these testers, the services they provide, or what their malaria care-seeking behaviour is in general. To better address these challenges, Breakthrough ACTION Guyana and MoPH conducted qualitative research from October to November 2018 in Regions 7 and 8 in Guyana.

Risk Factors for Malaria Infection and Seropositivity in the Elimination Area of Grand'Anse, Haiti: A Case-Control Study among Febrile Individuals Seeking Treatment at Public Health Facilities

May 29, 2020 - 14:24 -- Open Access
Author(s): 
Ashton RA, Joseph V, Eisele TP, et al.
Reference: 
Am J Trop Med Hyg. 2020 May 26.

The island of Hispaniola aims to eliminate malaria by 2025; however, there are limited data to describe epidemiologic risk factors for malaria in this setting. A prospective case–control study was conducted at four health facilities in southwest Haiti, aiming to describe factors influencing the risk of current and past malaria infection. Cases were defined as individuals attending facilities with current or recent fever and positive malaria rapid diagnostic test (RDT), whereas controls were those with current or recent fever and RDT negative.

Nanobiotechnological modules as molecular target tracker for the treatment and prevention of malaria: options and opportunity

May 19, 2020 - 14:12 -- Open Access
Author(s): 
Anamika J, Nikhar V, Laxmikant G, Priya S, Sonal V, Vyas SP
Reference: 
Drug Deliv Transl Res. 2020 May 7

Malaria is one of the major infectious diseases that remains a constant challenge to human being mainly due to the emergence of drug-resistant strains of parasite and also the availability of drugs, which are non-specific for their pharmacodynamic activity and known to be associated with multiple side effects. The disease has acquired endemic proportions in tropical countries where the hygienic conditions are not satisfactory while the environmental conditions favor the proliferation of parasite and its transmission, particularly through the female anopheles.

Cost-Effectiveness Analysis of Gender-Stratified Plasmodium vivax Treatment Strategies Using Available G6PD Diagnostics to Accelerate Access to Radical Cure

May 7, 2020 - 11:38 -- Open Access
Author(s): 
Devine A, Howes RE, Price DJ, Moore KA, Ley B, Simpson JA, Dittrich S, Price RN
Reference: 
Am J Trop Med Hyg. 2020 May 4

Tafenoquine has been licensed for the single-dose radical cure of Plasmodium vivax in adults; however, it is only recommended in patients with > 70% of normal glucose-6-phosphate dehydrogenase (G6PD) activity. Because this may hinder widespread use, we investigated gender-based treatment strategies in which all adult patients are tested with a qualitative G6PD rapid diagnostic test (RDT).

“We have this, with my husband, we live in harmony”: exploring the gendered decision-making matrix for malaria prevention and treatment in Nampula Province, Mozambique

March 31, 2020 - 15:59 -- Open Access
Author(s): 
Zoe Jane-Lara Hildon, Maria Escorcio-Ymayo, Rose Zulliger, Rosario Arias de Aramburú, Nan Lewicky, Hunter Harig, Jose Braz Chidassicua, Carol Underwood, Liliana Pinto and Maria Elena Figueroa
Reference: 
Malaria Journal 2020 19:133, 30 March 2020

Conceptualizing gender dynamics and ways of bridging entrenched gender roles will contribute to better health promotion, policy and planning. Such processes are explored in relation to malaria in Mozambique.

NOT Open Access | Gaps between Knowledge and Malaria Treatment Practices after Intensive Anti-Malaria Campaigns in Western Kenya: 2004-2016

March 23, 2020 - 14:08 -- NOT Open Access
Author(s): 
Zhou G, Hemming-Schroeder E, Gesuge M, Afrane YA, Lee MC, Atieli HE, Githeko AK, Yan G
Reference: 
Am J Trop Med Hyg. 2020 Mar 16

Effective case management is central for malaria control, but not all of those affected by malaria have access to prompt, effective treatment. In Kenya, free malaria treatment has been implemented since 2006. However, questions remain regarding effective treatment. We conducted cross-sectional epidemiological and questionnaire surveys in four counties in western Kenya in 2004, 2010, and 2016, and antimalarial availability surveys in 2016.

Evaluation of a capacity building intervention on malaria treatment for under-fives in rural health facilities in Niger State, Nigeria

March 2, 2020 - 14:52 -- Open Access
Author(s): 
Ayodele Jegede, Barbara Willey, Prudence Hamade, Fredrick Oshiname, Daniel Chandramohan, IkeOluwa Ajayi, Catherine Falade, Ebenezer Baba and Jayne Webster
Reference: 
Malaria Journal 2020 19:90, 24 February 2020

Despite the uptake of parasitological testing into policy and practice, appropriate prescription of anti-malarials and artemisinin-based combination therapy (ACT) in accordance with test results is variable. This study describes a National Malaria Control Programme-led capacity building intervention which was implemented in 10 States of Nigeria. Using the experience of Niger State, this study assessed the effect on malaria diagnosis and prescription practices among febrile under-fives in rural health facilities.

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