Chloroquines are 4‐aminoquinoline based drugs mainly used to treat malaria. At pharmacological concentrations they have significant effects on tissue homeostasis, targeting diverse signaling pathways in mammalian cells. A key target pathway is autophagy, which regulates macromolecule turnover in the cell.
We describe a symptomatic Plasmodium falciparum infection in a 29-year-old Guinean man receiving Infliximab since one year and without recent travel. The reactivation of submicroscopic malaria following the inhibition of TNF-alpha by infliximab is suspected.
While the malaria death count in Cambodia dropped to just one case in 2016, a new threat to the race against the disease arises in south-eastern Asia: superbugs. A superbug is a drug-resistant, human-killing parasite that modern medicine struggles to combat.
The analysis confirmed statistically-significant differences between the direct and indirect costs of treatment with and without chemoprophylaxis for patients with imported malaria.
RDT was cost effective in both low and high transmission settings.
In regions coendemic for P. vivax and P. falciparum, a unified treatment policy for malaria of any parasitological cause is likely to confer the greatest individual and public health benefit.
Four years after the withdrawal of CQ from national treatment guidelines the prevalence of the mutant pfcrt allele remains at 97%.
We present three cases of unusual and complicated malaria caused by Plasmodium vivax.
Community health workers can be trained to use RDTs and timers to assess and manage malaria and pneumonia in children.
Everybody used poor quality malaria treatment services but the poor people used providers with poor quality malaria treatment services more than others.