Treatment

Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin

Tags:

chloroquine, Treatment, malaria, Plasmodium vivax, patients, 2 years, 14 years, Brazilian Amazon basin

Author(s):

Luann Wendel Pereira de Sena, Amanda Gabryelle Nunes Cardoso Mello, Michelle Valéria Dias Ferreira, Marcieni Andrade de Ataide, Rosa Maria Dias and José Luiz Fernandes Vieira

Reference:

Malaria Journal 2019 18:439, 21 December 2019

A total dose of chloroquine of 25 mg/kg is recommended by the World Health Organization (WHO) to treat malaria by Plasmodium vivax. In several endemic areas, including the Brazilian Amazon basin, anti-malarial drugs are dispensed in small plastic bags at a dosing regimen based on age. This practice can lead to suboptimal dosing of the drug, which can impact treatment outcomes. The aim of the present study was to estimate the extent of sub-dosing of chloroquine in children and adolescents with vivax malaria using an age-based dose regimen, in addition to investigating the influence of age on the plasma concentrations of chloroquine and desethylchloroquine.

Monitoring of efficacy, tolerability and safety of artemether–lumefantrine and artesunate–amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon: an open-label clinical trial

Tags:

monitoring, efficacy, tolerability, artemether–lumefantrine, artesunate–amodiaquine, Treatment, plasmodium falciparum, malaria, Lambaréné, Gabon, clinical trial

Author(s):

Bayode R. Adegbite, Jean R. Edoa, Ayola A. Adegnika, et al.

Reference:

Malaria Journal 2019 18:424, 16 December 2019

Malaria remains a major public health problem, affecting mainly low-and middle-income countries. The management of this parasitic disease is challenged by ever increasing drug resistance. This study, investigated the therapeutic efficacy, tolerability and safety of artemether–lumefantrine (AL) and artesunate–amodiaquine (AS–AQ), used as first-line drugs to treat uncomplicated malaria in Lambaréné, Gabon.

Dissecting pharmacological effects of Chloroquine in cancer treatment: interference with inflammatory signaling pathways

Tags:

pharmacological, effects of Chloroquine, Treatment, interference, inflammatory, signaling pathways

Author(s):

Varisli L, Cen O, Vlahopoulos S.

Reference:

Immunology. 2019 Nov 28.

Chloroquines are 4‐aminoquinoline based drugs mainly used to treat malaria. At pharmacological concentrations they have significant effects on tissue homeostasis, targeting diverse signaling pathways in mammalian cells. A key target pathway is autophagy, which regulates macromolecule turnover in the cell.

NOT Open Access | Reactivation of Plasmodium infection during a treatment with Infliximab: a case report

Tags:

reactivation, plasmodium infection, Treatment, Infliximab

Author(s):

Haeseleer C, Martiny D, Van Laethem Y, Cantinieaux B, Martin C.

Reference:

International Journal of Infectious Diseases, 20 November 2019

We describe a symptomatic Plasmodium falciparum infection in a 29-year-old Guinean man receiving Infliximab since one year and without recent travel. The reactivation of submicroscopic malaria following the inhibition of TNF-alpha by infliximab is suspected.

Superbug: an emerging and quickly spreading threat to the race against malaria

Tags:

Automated Diagnosis, Automated Diagnostic App, children, diagnosis, eHealth, falciparum, Innovation, malaria eradication, medicine, plasmodium falciparum, Superbug, Treatment, vaccine, xRapid

While the malaria death count in Cambodia dropped to just one case in 2016, a new threat to the race against the disease arises in south-eastern Asia: superbugs. A superbug is a drug-resistant, human-killing parasite that modern medicine struggles to combat.

Open Access | Costs analysis of the treatment of imported malaria

Tags:

Treatment

Author(s):

Svihrova V, Szilagyiova M, Novakova E, Svihra J, Hudeckova H

Reference:

Malaria Journal 2012, 11:1 (2 January 2012)

MalariaWorld The analysis confirmed statistically-significant differences between the direct and indirect costs of treatment with and without chemoprophylaxis for patients with imported malaria.

Medical Condition:

malaria

Open Access | Cost-effectiveness of malaria microscopy and rapid diagnostic tests versus presumptive diagnosis: implications for malaria control in Uganda

Tags:

Treatment

Author(s):

Batwala V, Magnussen P, Hansen KS, Nuwaha F

Reference:

Malaria Journal 2011, 10:372 (19 December 2011)

MalariaWorld RDT was cost effective in both low and high transmission settings.

Country:

Uganda

Medical Condition:

malaria

Medical Treatment:

rapid diagnostic test (RDT)

artemether-lumefantrine (AL).

Plasmodium vivax treatments: what are we looking for?

Tags:

Treatment

Author(s):

Price, Ric N.; Douglas, Nicholas M.; Anstey, Nicholas M.; von Seidlein, Lorenz

Reference:

C urrent Opinion in Infectious Diseases, December 2011 - Volume 24 - Issue 6 - p 578–585

MalariaWorld In regions coendemic for P. vivax and P. falciparum, a unified treatment policy for malaria of any parasitological cause is likely to confer the greatest individual and public health benefit.