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Brain Magnetic Resonance Imaging Reveals Different Courses of Disease in Pediatric and Adult Cerebral Malaria

December 16, 2020 - 12:16 -- Open Access
Author(s): 
Sahu PK, Hoffmann A, Wassmer SC, et al.
Reference: 
Clin Infect Dis. 2020 Dec 16:ciaa1647

Cerebral malaria is a common presentation of severe Plasmodium falciparum infection and remains an important cause of death in the tropics. Key aspects of its pathogenesis are still incompletely understood, but severe brain swelling identified by magnetic resonance imaging (MRI) was associated with a fatal outcome in African children. In contrast, neuroimaging investigations failed to identify cerebral features associated with fatality in Asian adults.

Multiple insecticide resistance target sites in adult field strains of An. gambiae (s.l.) from southeastern Senegal

November 14, 2020 - 16:15 -- Open Access
Author(s): 
Diouf EH, Niang EHA, Samb B, Diagne CT, Diouf M, Konaté A, Dia I, Faye O, Konaté L
Reference: 
Parasit Vectors. 2020 Nov 11;13(1):567

High coverage of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are the cornerstones of vector control strategy in Senegal where insecticide resistance by the target vectors species is a great of concern. This study explores insecticide susceptibility profile and target-site mutations mechanisms within the Anopheles gambiae complex in southeastern Senegal.

Asymptomatic Plasmodium falciparum malaria prevalence among adolescents and adults in Malawi, 2015-2016

November 4, 2020 - 10:13 -- Open Access
Author(s): 
Topazian HM, Gumbo A, Juliano JJ, et al.
Reference: 
Sci Rep. 2020 Oct 30;10(1):18740

Malaria remains a significant cause of morbidity and mortality in Malawi, with an estimated 18-19% prevalence of Plasmodium falciparum in children 2-10 years in 2015-2016. While children report the highest rates of clinical disease, adults are thought to be an important reservoir to sustained transmission due to persistent asymptomatic infection.

Safety, Pharmacokinetics, and Mosquito-Lethal Effects of Ivermectin in Combination With Dihydroartemisinin-Piperaquine and Primaquine in Healthy Adult Thai Subjects

May 7, 2020 - 13:34 -- Open Access
Author(s): 
Kobylinski KC, Jittamala P, Tarning J, et al.
Reference: 
Clin Pharmacol Ther. 2020 May;107(5):1221-1230

Mass administration of antimalarial drugs and ivermectin are being considered as potential accelerators of malaria elimination. The safety, tolerability, pharmacokinetics, and mosquito‐lethal effects of combinations of ivermectin, dihydroartemisinin‐piperaquine, and primaquine were evaluated. Coadministration of ivermectin and dihydroartemisinin‐piperaquine resulted in increased ivermectin concentrations with corresponding increases in mosquito‐lethal effect across all subjects.

Not Open Access | Acute acalculous cholecystitis in malaria: a review of seven cases from an adult cohort

July 30, 2013 - 17:29 -- NOT Open Access
Tags: 
Author(s): 
C. Abreu, L. Santos, R. Poínhos, A. Sarmento
Reference: 
Infection, August 2013, Volume 41, Issue 4, pp 821-826
MalariaWorld

In this series, seven cases of AAC from a cohort of 42 adult patients with severe imported falciparum malaria [according to the World Health Organization (WHO) criteria] are presented. The aim is to report the cases and look for malaria conditions that may affect the incidence of this unusual malaria complication.

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