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PfSWIB, a potential chromatin regulator for var gene regulation and parasite development in Plasmodium falciparum

February 14, 2020 - 17:03 -- Open Access
Wang WF, Zhang YL
Parasites & Vectors volume 13, 48 (2020)

Various transcription factors are involved in the process of mutually exclusive expression and clonal variation of the Plasmodium multigene (var) family. Recent studies revealed that a P. falciparum SWI/SNF-related matrix-associated actin-dependent regulator of chromatin (PfSWIB) might trigger stage-specific programmed cell death (PCD), and was not only crucial for the survival and development of parasite, but also had profound effects on the parasite by interacting with other unknown proteins. However, it remains unclear whether PfSIWB is involved in transcriptional regulation of this virulence gene and its functional properties.

An in vitro toolbox to accelerate anti-malarial drug discovery and development

January 6, 2020 - 16:26 -- Open Access
Susan A. Charman, Alice Andreu, Nada Abla, et al.
Malaria Journal 2020 19:1, 2 January 2020

Modelling and simulation are being increasingly utilized to support the discovery and development of new anti-malarial drugs. These approaches require reliable in vitro data for physicochemical properties, permeability, binding, intrinsic clearance and cytochrome P450 inhibition. This work was conducted to generate an in vitro data toolbox using standardized methods for a set of 45 anti-malarial drugs and to assess changes in physicochemical properties in relation to changing target product and candidate profiles.

The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance

December 30, 2019 - 15:00 -- Open Access
Adam Saddler, Katharina S. Kreppel, Nakul Chitnis, Thomas A. Smith, Adrian Denz, Jason D. Moore, Mgeni M. Tambwe and Sarah J. Moore
Malaria Journal 2019 18:441, 23 December 2019

A clear understanding of mosquito biology is fundamental to the control efforts of mosquito-borne diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular method of measuring the survival and dispersal of disease vectors; however, examples with African malaria vectors are limited. Ethical and technical difficulties involved in carrying out MMRR studies may have held back research in this area and, therefore, a device that marks mosquitoes as they emerge from breeding sites was developed and evaluated to overcome the problems of MMRR.

What's this TH!NK3 all about?

March 30, 2010 - 20:59 -- Bart G.J. Knols

'TH!NK3: Developing world' is the third round of the European Journalism Centre's widely acclaimed international blogging competition series. The participants of TH!NK3 (called "TH!NKers") are journalism students, academics and experts from 27 EU Member States, neighbourhood countries and beyond.

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