The structural analyses presented here provide a framework for development of febrifugine derivatives that can seed development of new anti-malarials.
This study aimed at investigating the suppressive, prophylactic and curative activities of Nefang in Plasmodium infected rodent models.
A theoretical framework, as presented here, is thus relevant as the role of IPTi on accelerating the spread of drug resistance can be isolated in individual populations and when the populations are interconnected and interact.
We have synthesized fifty tricyclic guanidine derivatives based on batzelladine K backbone. All synthesized compounds were evaluated for anti-malarial activity against chloroquine resistant strains of P. falciparum by using plasmodial LDH activity as measure of inhibition.
The study provides evidence that there was an increased risk of eye disorders in users of all anti-malarials compared to non-users of anti-malarials.
Anti-malarial activity of the essential oil (EO) was evaluated in vitro against chloroquine-sensitive HB3 and chloroquine-resistant W2 strains of Plasmodium falciparum. Synergistic effect of chloroquine and the EO on parasite growth was evaluated by calculating the combination index.
Our findings suggest that the gene encoding MSP-9 is under purifying selection in P. vivax and closely related species.
This study reports the systematic and objective further interrogation of selected compounds reported in these studies, to enable their repositioning as novel stand-alone anti-malarials or as combinatorial partners.
This study investigated the use of non-prescribed anti-malarial drugs for the treatment of malaria in the Bolgatanga Municipality of northern Ghana.
Data for this report include patients with laboratory confirmed malaria who were prescribed anti-malarial therapy over a two-year period. Patient visits were analysed in two groups: those considered ACT candidates (defined as uncomplicated malaria with no referral for admission in patients >= 4 months of age and >= 5 kg in weight) and those who may not have been ACT candidates.