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Multinormal in vitro distribution of Plasmodium falciparum susceptibility to piperaquine and pyronaridine

February 27, 2015 - 16:19 -- Open Access
Aurélie Pascual, Marilyn Madamet, Sébastien Briolant, Tiphaine Gaillard, Rémy Amalvict, Nicolas Benoit, Dominique Travers, Bruno Pradines
Malaria Journal 2015, 14:49 (5 February 2015)

Dihydroartemisinin-piperaquine and artesunate-pyronaridine are two of these new combinations. The aim of the present work was to assess the distribution of the in vitro values of pyronaridine (PND) and piperaquine (PPQ) and to define a cut-off for reduced susceptibility for the two anti-malarial drugs.

Perceptions and utilization of the anti-malarials artemether-lumefantrine and dihydroartemisinin-piperaquine in young children in the Chikhwawa District of Malawi: a mixed methods study

February 3, 2015 - 15:50 -- Open Access
Victoria L Ewing, Dianne J Terlouw, Andrew Kapinda, Cheryl Pace, Esther Richards, Rachel Tolhurst, David G Lalloo
Malaria Journal 2015, 14:13 (21 January 2015)

Caregivers experience great difficulty in administering medication to children.

Medical Treatment: 

Not Open Access | Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase

January 22, 2015 - 14:42 -- NOT Open Access
Vitul Jain, Haruhisa Kikuchi, Yoshiteru Oshima, Amit Sharma, Manickam Yogavel
Journal of Structural and Functional Genomics, Volume 15, Issue 4, pp 181-190, December 2014

The structural analyses presented here provide a framework for development of febrifugine derivatives that can seed development of new anti-malarials.

Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models

December 5, 2014 - 07:22 -- Open Access
Protus Arrey Tarkang, Faith A Okalebo, Lawrence S Ayong, Gabriel A Agbor, Anastasia N Guantai
Malaria Journal 2014, 13:456 (25 November 2014)

This study aimed at investigating the suppressive, prophylactic and curative activities of Nefang in Plasmodium infected rodent models.

The effect of intermittent preventive treatment on anti-malarial drug resistance spread in areas with population movement

November 25, 2014 - 16:54 -- Open Access
Miranda I Teboh-Ewungkem, Jemal Mohammed-Awel, Frederick N Baliraine, Scott M Duke-Sylvester
Malaria Journal 2014, 13:428 (15 November 2014)

A theoretical framework, as presented here, is thus relevant as the role of IPTi on accelerating the spread of drug resistance can be isolated in individual populations and when the populations are interconnected and interact.

Not Open Access | Synthesis, biological evaluation and molecular docking studies of tricyclic guanidine derivatives for anti-malarial activity

March 10, 2014 - 18:00 -- NOT Open Access
Nafees Ahmed, Shabana I. Khan, Kamlesh K. Bhutani
Asian Pacific Journal of Tropical Disease, Volume 4, Issue 3, June 2014, Page 233

We have synthesized fifty tricyclic guanidine derivatives based on batzelladine K backbone. All synthesized compounds were evaluated for anti-malarial activity against chloroquine resistant strains of P. falciparum by using plasmodial LDH activity as measure of inhibition. 

Use of anti-malarial drugs and the risk of developing eye disorders

March 5, 2014 - 17:31 -- Open Access
Cornelia Schneider, Miriam Adamcova, Susan S. Jick, Patricia Schlagenhauf, Mary K. Miller, Hans-Georg Rhein, Christoph R. Meier
Travel Medicine and Infectious Disease, Volume 12, Issue 1, January–February 2014, Pages 40-47

The study provides evidence that there was an increased risk of eye disorders in users of all anti-malarials compared to non-users of anti-malarials.

Anti-malarial activity and HS-SPME-GC-MS chemical profiling of Plinia cerrocampanensis leaf essential oil

January 21, 2014 - 17:42 -- Open Access
Durant AA, Rodríguez C, Herrera L, Almanza A, Santana AI, Spadadora C, Gupta MP
Malaria Journal 2014, 13 :18 (13 January 2014)

Anti-malarial activity of the essential oil (EO) was evaluated in vitro against chloroquine-sensitive HB3 and chloroquine-resistant W2 strains of Plasmodium falciparum. Synergistic effect of chloroquine and the EO on parasite growth was evaluated by calculating the combination index.

Not Open Access | The evolution and diversity of a low complexity vaccine candidate, merozoite surface protein 9 (MSP-9), in Plasmodium vivax and closely related species

October 16, 2013 - 18:46 -- NOT Open Access
Stella M. Chenet, M. Andreína Pacheco, David J. Bacon, William E. Collins, John W. Barnwell, Ananias A. Escalante
Infection, Genetics and Evolution, Volume 20, December 2013, Pages 239-248

Our findings suggest that the gene encoding MSP-9 is under purifying selection in P. vivax and closely related species.

Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate

October 14, 2013 - 18:53 -- Open Access
Matthews H, Usman-Idris M, Khan F, Read M, Nirmalan N
Malaria Journal 2013, 12 :359 (9 October 2013)

This study reports the systematic and objective further interrogation of selected compounds reported in these studies, to enable their repositioning as novel stand-alone anti-malarials or as combinatorial partners.


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