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Toxoplasma gondii

NOT Open Access | The role of upstream open reading frames in translation regulation in the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii

June 9, 2021 - 13:13 -- NOT Open Access
Author(s): 
Kaur C, Patankar S
Reference: 
Parasitology. 2021 Jun 8:1-45

No abstract available

NOT Open Access | Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasma gondii Growth Through an Aspartate aminotransferase-independent Pathway

January 14, 2020 - 16:05 -- NOT Open Access
Author(s): 
Li J, Guo H, Galon EM, Gao Y, Lee SH, Liu M, Li Y, Ji S, Jia H, Xuan X
Reference: 
Antimicrob Agents Chemother. 2020 Jan 6. pii: AAC.01889-19

Toxoplasma gondii is an obligate intracellular protozoan parasite and a successful parasitic pathogen in diverse organisms and host cell types. Hydroxylamine (HYD) and carboxymethoxylamine (CAR) have been reported as inhibitors of aspartate aminotransferases (AATs), and interferes with the proliferation in Plasmodium falciparum. Therefore, AATs are suggested as drug targets against Plasmodium. T. gondii genome encodes only one predicted AAT in both T. gondii type I RH and type II PLK strains.

Not Open Access | Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii

December 10, 2019 - 08:43 -- NOT Open Access
Author(s): 
Rosenberg A, Luth MR, Winzeler EA, Behnke M, Sibley LD
Reference: 
Proc Natl Acad Sci U S A. 2019 Dec 5. pii: 201914732

Artemisinins are effective against a variety of parasites and provide the first line of treatment for malaria. Laboratory studies have identified several mechanisms for artemisinin resistance in Plasmodium falciparum, including mutations in Kelch13 that are associated with delayed clearance in some clinical isolates, although other mechanisms are likely involved.

Not Open Access | Evidence of tRNA cleavage in apicomplexan parasites: Half-tRNAs as new potential regulatory molecules of Toxoplasma gondii and Plasmodium berghei

May 17, 2013 - 16:28 -- NOT Open Access
Author(s): 
Roberto Galizi, Furio Spano, Manlio Di Cristina, et al.
Reference: 
Molecular and Biochemical Parasitology, Volume 188, Issue 2, April 2013, Pages 99-108
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Collectively, our findings shed light for the first time on the occurrence of tRNA cleavage in apicomplexan parasites and suggest a relationship between half-tRNA production and growth rate in this important group of organisms.

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