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antimalaria

Antimalarial Activity of Plant Metabolites

May 10, 2018 - 16:03 -- Open Access
Author(s): 
Wen-Hui Pan , Xin-Ya Xu , Ni Shi , Siu Wai Tsang and Hong-Jie Zhang
Reference: 
Int. J. Mol. Sci. 2018, 19(5), 1382

Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum.

Spatial distribution and cluster analysis of retail drug shop characteristics and antimalarial behaviors as reported by private medicine retailers in western Kenya: informing future interventions

February 23, 2016 - 14:28 -- Open Access
Author(s): 
Rusk A, Highfield L, Wilkerson JM, Harrell M, Obala A, Amick B
Reference: 
International Journal of Health Geographics 2016, 15 :9 (19 February 2016)

This research conducted cluster analysis on medicine retailer behaviors in Kenya, to improve malaria case management and inform future interventions.

Antimalarial drugs for preventing malaria during pregnancy and the risk of low birth weight: a systematic review and meta-analysis of randomized and quasi-randomized trials

August 18, 2015 - 16:17 -- Open Access
Author(s): 
Flory Tsobo Muanda, Sonia Chaabane, Takoua Boukhris, Fabiano Santos, Odile Sheehy, Sylvie Perreault, Lucie Blais and Anick Bérard
Reference: 
BMC Medicine 2015, 13:193

In addition, no systematic review exists comparing current recommendations for malaria prevention during pregnancy to alternative regimens in Africa. Therefore, we conducted a comprehensive systematic review and meta-analysis to assess the efficacy of antimalarial drugs for malaria prevention during pregnancy in reducing the risk of LBW.

Diversity of Anopheles mosquitoes in Binh Phuoc and Dak Nong Provinces of Vietnam and their relation to disease

July 22, 2014 - 19:14 -- Open Access
Author(s): 
Chung Thuy Ngo, Gregor Dubois, Véronique Sinou, Daniel Parzy, Hong Quang Le, Ralph E Harbach and Sylvie Manguin
Reference: 
Parasites & Vectors 2014, 7:316

The objective of this study was to investigate the role of Anopheles species in the transmission of these two pathogens in the two highly malaria endemic provinces of Vietnam.

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Not Open Access | To kill or not to kill, that is the question: cytocidal antimalarial drug resistance

March 24, 2014 - 18:43 -- NOT Open Access
Author(s): 
Paul D. Roepe
Reference: 
Trends in Parasitology, Volume 30, Issue 3, March 2014, Pages 130-135

These conclusions have important implications for elucidating other drug resistance phenomena and emphasize new concepts that are essential for the development of new drug therapy.

Pharmacological considerations in the design of anti-malarial drug combination therapies - is matching half-lives enough?

February 26, 2014 - 16:34 -- Open Access
Author(s): 
Malaria Journal 2014, 13 :62 (20 February 2014)
Reference: 
Hastings IM, Hodel EM

This strategy is justified by mathematical arguments that generally assume that drug 'resistance' is a binary all-or-nothing genetic trait. Herein, a pharmacological, rather than a purely genetic, approach is used to investigate resistance and it is argued that this provides additional insight into the design principles of anti-malarial CTs. 

Not Open Access | The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether

February 26, 2014 - 16:28 -- NOT Open Access
Author(s): 
Ryan C. Conyers, Jennifer R. Mazzone, Maxime A. Siegler, Abhai K. Tripathi, David J. Sullivan, Bryan T. Mott, Gary H. Posner
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 24, Issue 5, 1 March 2014, Pages 1285-1289

This ACT chemotherapy result is of high medicinal significance because the antimalarial efficacy of the popular trioxane drug artemether (2) plus mefloquine under the same conditions was significantly lower (only 20 day average survival). 

Not Open Access | Antimalarial drug discovery — approaches and progress towards new medicines

December 11, 2013 - 17:38 -- NOT Open Access
Author(s): 
Erika L. Flannery, Arnab K. Chatterjee & Elizabeth A. Winzeler
Reference: 
Nature Reviews Microbiology 11, 849–862 (2013)

In this Review, we discuss the cell-, chemistry- and target-based approaches used to discover new drug candidates that are currently in clinical trials or undergoing preclinical testing.

Not Open Access | Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy

October 7, 2013 - 14:08 -- NOT Open Access
Author(s): 
Rahul P. Bakshi, Elizabeth Nenortas, Abhai K. Tripathi, David J. Sullivan and Theresa A. Shapiro
Reference: 
Sci Transl Med 2 October 2013: Vol. 5, Issue 205, p. 205ra135
MalariaWorld

We devised an in vitro system for P. falciparum, capable of mimicking the dynamic fluctuations of a drug in vivo

Exchange Transfusion for Severe Malaria: Evidence Base and Literature Review

September 11, 2013 - 18:44 -- Open Access
Author(s): 
Kathrine R. Tan, Ryan E. Wiegand, and Paul M. Arguin
Reference: 
Clin Infect Dis. (2013) 57 (7): 923-928.
MalariaWorld

We examined the efficacy of ET as an adjunct treatment for severe malaria using US surveillance data and reviewed the literature to update recommendations.

Country: 

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