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anopheles mosquitoes

NOT Open Access | Species Composition, Parous Rate, and Infection Rate of Anopheles Mosquitoes (Diptera: Culicidae) in Bahir Dar City Administration, Northwest Ethiopia

April 7, 2021 - 12:12 -- NOT Open Access
Getaneh A, Yimer M, Alemu M, Dejazmach Z, Alehegn M, Tegegne B
J Med Entomol. 2021 Apr 3:tjab034

Anopheles mosquitoes are the main vectors of malaria. There is little information on the current entomological aspects of Anopheles mosquitoes in Amhara region of northwestern Ethiopia. Therefore, the aim of this study was to assess the prevailing species composition, parous rate, and infection rate of Anopheles mosquitoes in the Bahir Dar city administration.

Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control

March 18, 2021 - 16:08 -- Open Access
O'Loughlin SM, Forster AJ, Fuchs S, Dottorini T, Nolan T, Crisanti A, Burt A
G3 (Bethesda). 2021 Mar 17:jkab086

DNA sequences that are exactly conserved over long evolutionary time scales have been observed in a variety of taxa. Such sequences are likely under strong functional constraint and they have been useful in the field of comparative genomics for identifying genome regions with regulatory function. A potential new application for these ultra-conserved elements has emerged in the development of gene drives to control mosquito populations. Many gene drives work by recognising and inserting at a specific target sequence in the genome, often imposing a reproductive load as a consequence.

NOT Open Access | Patterns of human exposure to early-evening and outdoor biting mosquitoes and residual malaria transmission in Ethiopia

January 27, 2021 - 10:53 -- NOT Open Access
Degefa T, Githeko AK, Lee MC, Yan G, Yewhalaw D
Acta Trop. 2021 Jan 21:105837

Ethiopia has shown a notable progress in reducing malaria burden over the past decade, mainly due to the scaleup of vector control interventions such as long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS). Based on the progress, the country has set goals to eliminate malaria by 2030. However, residual malaria transmission due to early-evening and outdoor biting vectors could pose a challenge to malaria elimination efforts. This study assessed vector behavior, patterns of human exposure to vector bites and residual malaria transmission in southwestern Ethiopia. Anopheles mosquitoes were collected monthly from January to December 2018 using human landing catches (HLCs), human-baited double net traps, CDC light traps and pyrethrum spray catches.

Zonal human hepatocytes are differentially permissive to Plasmodium falciparum malaria parasites

January 20, 2021 - 06:25 -- Open Access
Yang ASP, van Waardenburg YM, van de Vegte-Bolmer M, van Gemert GA, Graumans W, de Wilt JHW, Sauerwein RW
EMBO J. 2021 Jan 18:e106583

Plasmodium falciparum (Pf) is a major cause of human malaria and is transmitted by infected Anopheles mosquitoes. The initial asymptomatic infection is characterized by parasite invasion of hepatocytes, followed by massive replication generating schizonts with blood-infective merozoites. Hepatocytes can be categorized by their zonal location and metabolic functions within a liver lobule. To understand specific host conditions that affect infectivity, we studied Pf parasite liver stage development in relation to the metabolic heterogeneity of fresh human hepatocytes.

Widespread zoophagy and detection of Plasmodium spp. in Anopheles mosquitoes in southeastern Madagascar

January 13, 2021 - 08:25 -- Open Access
Micaela Finney, Benjamin A. McKenzie, Bernadette Rabaovola, Alice Sutcliffe, Ellen Dotson and Sarah Zohdy
Malaria Journal 2021 20:25, 7 January 2021

Malaria is a top cause of mortality on the island nation of Madagascar, where many rural communities rely on subsistence agriculture and livestock production. Understanding feeding behaviours of Anopheles in this landscape is crucial for optimizing malaria control and prevention strategies. Previous studies in southeastern Madagascar have shown that Anopheles mosquitoes are more frequently captured within 50 m of livestock. However, it remains unknown whether these mosquitoes preferentially feed on livestock. Here, mosquito blood meal sources and Plasmodium sporozoite rates were determined to evaluate patterns of feeding behaviour in Anopheles spp. and malaria transmission in southeastern Madagascar.

Efficacy of extended release formulations of Natular™ (spinosad) against larvae and adults of Anopheles mosquitoes in western Kenya

November 28, 2020 - 16:26 -- Open Access
John E. Gimnig, Maurice Ombok, Nabie Bayoh, Derrick Mathias, Eric Ochomo, William Jany and Edward D. Walker
Malaria Journal 2020 19:436, 26 November 2020

Larval source management is recommended as a supplementary vector control measure for the prevention of malaria. Among the concerns related to larviciding is the feasibility of implementation in tropical areas with large numbers of habitats and the need for frequent application. Formulated products of spinosad that are designed to be effective for several weeks may mitigate some of these concerns.

Identification keys to the Anopheles mosquitoes of South America (Diptera: Culicidae). I. Introduction

November 19, 2020 - 13:53 -- Open Access
Sallum MAM, Obando RG, Carrejo N, Wilkerson RC
Parasit Vectors. 2020 Nov 18;13(1):583

The worldwide genus Anopheles Meigen, 1918 is the only genus containing species evolved as vectors of human and simian malaria. Morbidity and mortality caused by Plasmodium Marchiafava & Celli, 1885 is tremendous, which has made these parasites and their vectors the objects of intense research aimed at mosquito identification, malaria control and elimination. DNA tools make the identification of Anopheles species both easier and more difficult. Easier in that putative species can nearly always be separated based on DNA data; more difficult in that attaching a scientific name to a species is often problematic because morphological characters are often difficult to interpret or even see; and DNA technology might not be available and affordable. Added to this are the many species that are either not yet recognized or are similar to, or identical with, named species. The first step in solving Anopheles identification problem is to attach a morphology-based formal or informal name to a specimen. These names are hypotheses to be tested with further morphological observations and/or DNA evidence. The overarching objective is to be able to communicate about a given species under study. In South America, morphological identification which is the first step in the above process is often difficult because of lack of taxonomic expertise and/or inadequate identification keys, written for local fauna, containing the most consequential species, or obviously, do not include species described subsequent to key publication.

Identification keys to the Anopheles mosquitoes of South America (Diptera: Culicidae). IV. Adult females

November 19, 2020 - 13:27 -- Open Access
Sallum MAM, Obando RG, Carrejo N, Wilkerson RC
Parasit Vectors. 2020 Nov 18;13(1):584

Morphological identification of adult females of described species of the genus Anopheles Meigen, 1818 in South America is problematic, but necessary due to their differing roles in the transmission of human malaria. The increase in the number of species complexes uncovered by molecular taxonomy challenges accurate identification using morphology. In addition, the majority of newly discovered species have not been formally described and in some cases the identities of the nominotypical species of species complexes have not been resolved. Here, we provide an up-to-date key to identify Neotropical Anopheles species using female external morphology and employing traditionally used and new characters.

Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes

September 23, 2020 - 08:41 -- Open Access
Volohonsky G, Paul-Gilloteaux P, Štáfková J, Soichot J, Salamero J, Levashina EA
PLoS Pathog. 2020 Sep 18;16(9):e1008739

Malaria-causing Plasmodium parasites traverse the mosquito midgut cells to establish infection at the basal side of the midgut. This dynamic process is a determinant of mosquito vector competence, yet the kinetics of the parasite migration is not well understood.

Plasmodium falciparum gametocyte-induced volatiles enhance attraction of Anopheles mosquitoes in the field

September 8, 2020 - 11:54 -- Open Access
Yared Debebe, Sharon Rose Hill, Göran Birgersson, Habte Tekie and Rickard Ignell
Malaria Journal 2020 19:327, 4 September 2020

Plasmodium parasites manipulate the interaction between their mosquito and human hosts. Patients infected with gametocytes attract anopheline mosquitoes differentially compared to healthy individuals, an effect associated with an increased release of attractive volatile cues. This odour-driven manipulation is partly mediated by the gametocyte-specific metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), which induces increased release of select aldehydes and terpenes from red blood cells and results in the enhanced attraction of host-seeking mosquitoes, which are vectors of malaria. This study investigates the effect of the HMBPP-induced volatiles on the attraction of wild Anopheles mosquitoes to humans under field conditions.


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