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anopheles mosquitoes

Molecular detection and maternal transmission of a bacterial symbiont Asaia species in field-caught Anopheles mosquitoes from Cameroon

October 20, 2021 - 19:58 -- Open Access
Maffo CGT, Sandeu MM, Fadel AN, Tchouakui M, Nguete DN, Menze B, Kusimo MO, Njiokou F, Hughes GL, Wondji CS
Parasit Vectors. 2021 Oct 17;14(1):539

Malaria control relies mainlyon insecticide-based tools. However, the effectiveness of these tools is threatened by widespread insecticide resistance in malaria vectors, highlighting the need for alternative control approaches. The endosymbiont Asaia has emerged as a promising candidate for paratransgenic control of malaria, but its biology and genetics still need to be further analyzed across Africa. Here, we investigated the prevalence of Asaia and its maternal transmission in the natural population of Anopheles mosquitoes in Cameroon.

A portfolio of geographically distinct laboratory-adapted Plasmodium falciparum clones with consistent infection rates in Anopheles mosquitoes

October 9, 2021 - 09:41 -- Open Access
Marga van de Vegte-Bolmer, Wouter Graumans, Rianne Stoter, Geert-Jan van Gemert, Robert Sauerwein, Katharine A. Collins and Teun Bousema
Malaria Journal 2021 20:381, 26 September 2021

The ability to culture Plasmodium falciparum continuously in vitro has enabled stable access to asexual and sexual parasites for malaria research. The portfolio of isolates has remained limited and research is still largely based on NF54 and its derived clone 3D7. Since 1978, isolates were collected and cryopreserved at Radboudumc from patients presenting at the hospital. Here, procedures are described for culture adaptation of asexual parasites, cloning and production of sexual stage parasites responsible for transmission (gametocytes) and production of oocysts in Anopheles mosquitoes. This study aimed to identify new culture-adapted transmissible P. falciparum isolates, originating from distinct geographical locations.

Tracking severe malaria disease

August 25, 2021 - 16:00 -- Open Access
Taylor T, Slutsker L
Science. 2021 Aug 20;373(6557):855-856

Female Anopheles mosquitoes transmit malaria sporozoites to humans in the context of a blood meal. In malaria-endemic areas, most of the ensuing infections are asymptomatic. Some, however, progress to an uncomplicated illness (fever, headache, body aches, and pains).

Not Open Access | The best sugar in town for malaria transmission

July 20, 2021 - 11:19 -- NOT Open Access
Ernest M, Alves E Silva TL, Vega-Rodríguez J
Trends Parasitol. 2021 Jul 15:S1471-4922(21)00163-X

Anopheles mosquitoes feed on plant nectars as their main source of sugar. Wang et al. show that Asaia bacteria proliferate in the midgut of mosquitoes that feed on glucose or trehalose.

Improvement of water quality for mass anopheline rearing: evaluation of the impact of ammonia-capturing zeolite on larval development and adult phenotypic quality

May 25, 2021 - 14:41 -- Open Access
Akpodiete NO, Tripet F
Parasit Vectors. 2021 May 20;14(1):268

Malaria vector control approaches that rely on mosquito releases such as the sterile insect technique (SIT) and suppression or replacement strategies relying on genetically modified mosquitoes (GMM) depend on effective mass production of Anopheles mosquitoes. Anophelines typically require relatively clean larval rearing water, and water management techniques that minimise toxic ammonia are key to achieving optimal rearing conditions in small and large rearing facilities. Zeolites are extensively used in closed-system fish aquaculture to improve water quality and reduce water consumption, thanks to their selective adsorption of ammonia and toxic heavy metals. The many advantages of zeolites include low cost, abundance in many parts of the world and environmental friendliness. However, so far, their potential benefit for mosquito rearing has not been evaluated.

Molecular diagnosis and therapy for Plasmodium ovale infection of a returned traveler from East Africa

May 12, 2021 - 13:09 -- Open Access
Tseng YC, Chang YC, Lee C, Hsu SF, Chang PC, Hsu JJ, Lin PB, Lu MC, Tien N, Hsiao CT
J Formos Med Assoc. 2021 May 6:S0929-6646(21)00170-4

Malaria is an infectious disease caused by Plasmodium parasites that are mainly transmitted through the bites of infected female Anopheles mosquitoes. The average annual number of malaria cases was less than ten in Taiwan in the last five years.

Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes

May 5, 2021 - 11:38 -- Open Access
Biddau M, Santha Kumar TR, Sheiner L, et al.
Int J Parasitol. 2021 May;51(6):441-453

Malaria is still one of the most important global infectious diseases. Emergence of drug resistance and a shortage of new efficient antimalarials continue to hamper a malaria eradication agenda. Malaria parasites are highly sensitive to changes in the redox environment. Understanding the mechanisms regulating parasite redox could contribute to the design of new drugs.

NOT Open Access | Olfaction in Anopheles mosquitoes

April 28, 2021 - 13:57 -- NOT Open Access
Konopka JK, Task D, Afify A, Raji J, Deibel K, Maguire S, Lawrence R, Potter CJ
Chem Senses. 2021 Apr 22:bjab021

As vectors for disease, mosquitoes are a global threat to human health. The Anopheles mosquito is the deadliest mosquito species as the insect vector for the malaria-causing parasite, which kills hundreds of thousands every year.

NOT Open Access | Species Composition, Parous Rate, and Infection Rate of Anopheles Mosquitoes (Diptera: Culicidae) in Bahir Dar City Administration, Northwest Ethiopia

April 7, 2021 - 12:12 -- NOT Open Access
Getaneh A, Yimer M, Alemu M, Dejazmach Z, Alehegn M, Tegegne B
J Med Entomol. 2021 Apr 3:tjab034

Anopheles mosquitoes are the main vectors of malaria. There is little information on the current entomological aspects of Anopheles mosquitoes in Amhara region of northwestern Ethiopia. Therefore, the aim of this study was to assess the prevailing species composition, parous rate, and infection rate of Anopheles mosquitoes in the Bahir Dar city administration.

Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control

March 18, 2021 - 16:08 -- Open Access
O'Loughlin SM, Forster AJ, Fuchs S, Dottorini T, Nolan T, Crisanti A, Burt A
G3 (Bethesda). 2021 Mar 17:jkab086

DNA sequences that are exactly conserved over long evolutionary time scales have been observed in a variety of taxa. Such sequences are likely under strong functional constraint and they have been useful in the field of comparative genomics for identifying genome regions with regulatory function. A potential new application for these ultra-conserved elements has emerged in the development of gene drives to control mosquito populations. Many gene drives work by recognising and inserting at a specific target sequence in the genome, often imposing a reproductive load as a consequence.


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