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artemisinin combination therapy (ACT)

NOT Open Access | Altered Drug Transport by Plasmodium Falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance

June 29, 2020 - 16:27 -- NOT Open Access
Riegel BE, Roepe PD
Biochemistry. 2020 Jun 26

Patterns of multiple amino acid substitutions in the Plasmodium falciparum chloroquine resistance transporter (PfCRT; UniProtKB - Q8IBZ9) have previously been shown to mediate chloroquine resistance (CQR) in P. falciparum malarial parasites. Recent reports suggest that novel mutations in PfCRT may mediate resistance to piperaquine (PPQ), which is used extensively as a partner drug in one prominent artemisinin combination therapy (ACT).

Management of febrile children under five years in hospitals and health centres of rural Ghana

July 22, 2014 - 08:55 -- Open Access
Webster J, Baiden F, Bawah J, Bruce J, Tivura M, Delmini R, Amenga-Etego S, Chandramohan D, Owusu-Agyei S
Malaria Journal 2014, 13 :261 (9 July 2014)

Interventions to improve adherence to negative parasitological tests are needed, together with guidance on dispensing of antibiotics, but improving the education of carers on how to administer ACT will lead to the greatest immediate increase in the effectiveness of case management.


Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal

April 18, 2013 - 06:45 -- Open Access
Rachel Daniels, Hsiao-Han Chang, Sarah K. Volkman, et al.
PLoS ONE 8(4): e60780

Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011.

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