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Bangladesh

Implementing radical cure diagnostics for malaria: user perspectives on G6PD testing in Bangladesh

May 18, 2021 - 13:36 -- Open Access
Author(s): 
Nora Engel, Cristian Ghergu, Mohammad Abdul Matin, Mohammad Golam Kibria, Kamala Thriemer, Ric N. Price, Xavier C. Ding, Rosalind E. Howes, Benedikt Ley, Sandra Incardona and Mohammad Shafiul Alam
Reference: 
Malaria Journal 2021 20:217, 12 May 2021

The radical cure of Plasmodium vivax requires treatment with an 8-aminoquinoline drug, such as primaquine and tafenoquine, to eradicate liver hypnozoite stages, which can reactivate to cause relapsing infections. Safe treatment regimens require prior screening of patients for glucose-6-phosphate dehydrogenase (G6PD) deficiency to avoid potential life-threatening drug induced haemolysis. Testing is rarely available in malaria endemic countries, but will be needed to support routine use of radical cure. This study investigates end-user perspectives in Bangladesh on the introduction of a quantitative G6PD test (SD Biosensor STANDARD™ G6PD analyser) to support malaria elimination.

Glucose-6-phosphate dehydrogenase activity in individuals with and without malaria: Analysis of clinical trial, cross-sectional and case-control data from Bangladesh

April 28, 2021 - 14:19 -- Open Access
Author(s): 
Ley B, Alam MS, Price RN, et al.
Reference: 
PLoS Med. 2021 Apr 23;18(4):e1003576

Glucose-6-phosphate dehydrogenase (G6PD) activity is dependent upon G6PD genotype and age of the red blood cell (RBC) population, with younger RBCs having higher activity. Peripheral parasitemia with Plasmodium spp. induces hemolysis, replacing older RBCs with younger cells with higher G6PD activity. This study aimed to assess whether G6PD activity varies between individuals with and without malaria or a history of malaria.

Disparities in Risks of Malaria Associated with Climatic Variability among Women, Children and Elderly in the Chittagong Hill Tracts of Bangladesh

December 23, 2020 - 09:12 -- Open Access
Author(s): 
Emeto TI, Adegboye OA, Rumi RA, Khan MI, Adegboye M, Khan WA, Rahman M, Streatfield PK, Rahman KM
Reference: 
Int J Environ Res Public Health. 2020 Dec 17;17(24):E9469

Malaria occurrence in the Chittagong Hill Tracts in Bangladesh varies by season and year, but this pattern is not well characterized. The role of environmental conditions on the occurrence of this vector-borne parasitic disease in the region is not fully understood. We extracted information on malaria patients recorded in the Upazila (sub-district) Health Complex patient registers of Rajasthali in Rangamati district of Bangladesh from February 2000 to November 2009. Weather data for the study area and period were obtained from the Bangladesh Meteorological Department.

NOT Open Access | Persistence of Markers of Chloroquine Resistance in Plasmodium falciparum in Bangladesh

November 7, 2020 - 12:23 -- NOT Open Access
Author(s): 
Johora FT, Elahi R, Nima MK, Hossain MS, Rashid H, Kibria MG, Mohon AN, Khan WA, Haque R, Alam MS
Reference: 
Am J Trop Med Hyg. 2020 Nov 2

The control of malaria, in terms of drug resistance, remains a significant global challenge, with Bangladesh, a malaria-endemic country, being no exception. The aim of this study was to explore antimalarial resistance in Bangladesh by molecular analysis of Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance transporter 1 (pfmdr1) genetic markers of P. falciparum.

Clustering-Based Dual Deep Learning Architecture for Detecting Red Blood Cells in Malaria Diagnostic Smears

November 3, 2020 - 15:25 -- Open Access
Author(s): 
Kassim YM, Palaniappan K, Yang F, Poostchi M, Palaniappan N, Maude RJ, Antani S, Jaeger S
Reference: 
IEEE J Biomed Health Inform. 2020 Oct 29;PP

Computer-assisted algorithms have become a mainstay of biomedical applications to improve accuracy and reproducibility of repetitive tasks like manual segmentation and annotation. We propose a novel pipeline for red blood cell detection and counting in thin blood smear microscopy images, named RBCNet, using a dual deep learning architecture. RBCNet consists of a U-Net first stage for cell-cluster segmentation, followed by a second stage Faster R-CNN for detecting small cell objects within clusters, identified as connected components from the U-Net stage.

Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests

September 24, 2020 - 08:07 -- Open Access
Author(s): 
André Barembaye Sagna, Mohammad Golam Kibria, Shamsun Naher, Shayla Islam, M. M. Aktaruzzaman, Mohammad Shafiul Alam and Cristian Koepfli
Reference: 
Malaria Journal 2020 19:345, 23 September 2020

Surveillance of low-density infections and of exposure to vectors is crucial to understand where malaria elimination might be feasible, and where the risk of outbreaks is high. Archived rapid diagnostic tests (RDTs), used by national malaria control and elimination programs for clinical diagnosis, present a valuable, yet rarely used resource for in-depth studies on malaria epidemiology.

NOT Open Access | Retinal involvement in severe noncerebral malaria

August 25, 2020 - 08:21 -- NOT Open Access
Author(s): 
Lando L, Borooah S, Maude RJ
Reference: 
Can J Ophthalmol. 2020 Aug 20:S0008-4182(20)30675-X

A 20-year-old male patient complained of reduced vision after being admitted to a hospital in Bangladesh with 5 days of fever associated with convulsions and anemia (hematocrit 11%). Uncorrected visual acuity was 20/80 OD and 20/64 OS.

NOT Open Access | Preliminary Report of Pyrethroid Resistance in Anopheles vagus, an Important Malaria Vector in Bangladesh

August 12, 2020 - 15:10 -- NOT Open Access
Author(s): 
Alam MS, Al-Amin HM, Khan WA, Haque R, Nahlen BL, Lobo NF
Reference: 
Am J Trop Med Hyg. 2020 Aug;103(2):810-811

According to the WHO, unmanaged insecticide resistance may lead to increases in malaria-related mortality and morbidity. Bangladesh, having made significant progress in malaria control efforts, has recently seen an upswing in malaria cases-58% of which occurred in Bandarban district. Toward identifying entomological drivers of increased malaria, an entomological survey including Anopheles susceptibility to the insecticides in use was conducted in Bandarban.

Cost-effective analysis of childhood malaria vaccination in endemic hotspots of Bangladesh

June 1, 2020 - 16:44 -- Open Access
Author(s): 
Sarker AR, Sultana M
Reference: 
PLoS ONE 15(5): e0233902

Bangladesh has a history of endemic malaria transmission, with 17.5 million people at risk. The objective of this study was to assess the cost-effectiveness of universal childhood malaria vaccination in Chittagong Hill Tracts (CHT) of Bangladesh with newly developed RTS,S/AS01 malaria vaccines.

NOT Open Access | Preliminary Report of Pyrethroid Resistance in Anopheles vagus, an Important Malaria Vector in Bangladesh

May 13, 2020 - 14:44 -- NOT Open Access
Author(s): 
Alam MS, Al-Amin HM, Khan WA, Haque R, Nahlen BL, Lobo NF
Reference: 
Am J Trop Med Hyg. 2020 May 11

According to the WHO, unmanaged insecticide resistance may lead to increases in malaria-related mortality and morbidity. Bangladesh, having made significant progress in malaria control efforts, has recently seen an upswing in malaria cases—58% of which occurred in Bandarban district.

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