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Thailand

Genetic analysis of the orthologous crt and mdr1 genes in Plasmodium malariae from Thailand and Myanmar

September 1, 2020 - 10:28 -- Open Access
Author(s): 
Yupawadee Pimpat, Naowarat Saralamba, Usa Boonyuen, Sasithon Pukrittayakamee, Francois Nosten, Frank Smithuis, Nicholas P. J. Day, Arjen M. Dondorp and Mallika Imwong
Reference: 
Malaria Journal 2020 19:315, 31 August 2020

Plasmodium malariae is a widely spread but neglected human malaria parasite, which causes chronic infections. Studies on genetic polymorphisms of anti-malarial drug target genes in P. malariae are limited. Previous reports have shown polymorphisms in the P. malariae dihydrofolate reductase gene associated with pyrimethamine resistance and linked to pyrimethamine drug pressure. This study investigated polymorphisms of the P. malariae homologous genes, chloroquine resistant transporter and multidrug resistant 1, associated with chloroquine and mefloquine resistance in Plasmodium falciparum.

The characterization of extracellular vesicles-derived microRNAs in Thai malaria patients

August 11, 2020 - 13:52 -- Open Access
Author(s): 
Nutpakal Ketprasit, Iris Simone Cheng, Fiona Deutsch, Nham Tran, Mallika Imwong, Valery Combes and Duangdao Palasuwan
Reference: 
Malaria Journal 2020 19:285, 10 August 2020

Extracellular vesicles (EVs) have been broadly studied in malaria for nearly a decade. These vesicles carry various functional biomolecules including RNA families such as microRNAs (miRNA). These EVs-derived microRNAs have numerous roles in host-parasite interactions and are considered promising biomarkers for disease severity. However, this field lacks clinical studies of malaria-infected samples. In this study, EV specific miRNAs were isolated from the plasma of patients from Thailand infected with Plasmodium vivax and Plasmodium falciparum. In addition, it is postulated that these miRNAs were differentially expressed in these groups of patients and had a role in disease onset through the regulation of specific target genes.

NOT Open Access | Structural diversity, natural selection and intragenic recombination in the Plasmodium vivax merozoite surface protein 9 locus in Thailand

July 29, 2020 - 10:21 -- NOT Open Access
Author(s): 
Songsaigath S, Putaporntip C, Kuamsab N, Jongwutiwes S
Reference: 
Infect Genet Evol. 2020 Jul 22:104467

The merozoite surface protein 9 (MSP9) of malarial parasite forms co-ligand complex with the 19 kDa fragment of merozoite surface protein 1 (MSP1) prior to erythrocyte invasion. Interruption of this process could hamper subsequent asexual erythrocytic development of malaria parasites; therefore, these proteins are considered potential vaccine candidates. In Plasmodium vivax, MSP9 (PvMSP9) contains both conserved and polymorphic repetitive domains that were immunogenic upon natural malaria exposure and conferred protection in vaccination studies in animal models.

Malaria cross-sectional surveys identified asymptomatic infections of Plasmodium falciparum, Plasmodium vivax, and Plasmodium knowlesi in Surat Thani, a southern province of Thailand

May 19, 2020 - 14:35 -- Open Access
Author(s): 
Shimizu S, Chotirat S, Nguitragool W, et al.
Reference: 
Int J Infect Dis. 2020 May 10:S1201-9712(20)30329-5

Malaria cross-sectional surveys are rarely conducted in very low transmission settings. This study aimed to determine the prevalence and risk factors of Plasmodium infection in a near-elimination setting in southern Thailand.

Molecular characterization of Plasmodium falciparum antifolate resistance markers in Thailand between 2008 and 2016

March 9, 2020 - 14:11 -- Open Access
Author(s): 
Rungniran Sugaram, Kanokon Suwannasin, Chanon Kunasol, Vivek Bhakta Mathema, Nicholas P. J. Day, Prayuth Sudathip, Preecha Prempree, Arjen M. Dondorp and Mallika Imwong
Reference: 
Malaria Journal 2020 19:107, 4 March 2020

Resistance to anti-malarials is a major threat to the control and elimination of malaria. Sulfadoxine–pyrimethamine (SP) anti-malarial treatment was used as a national policy for treatment of uncomplicated falciparum malaria in Thailand from 1973 to 1990. In order to determine whether withdrawal of this antifolate drug has led to restoration of SP sensitivity, the prevalence of genetic markers of SP resistance was assessed in historical Thai samples.

Malaria-associated rubber plantations in Thailand

April 12, 2013 - 16:37 -- Open Access
Author(s): 
Adisak Bhumiratana, Prapa Sorosjinda-Nunthawarasilp, Wuthichai Kaewwaen, Pannamas Maneekan, Suntorn Pimnon
Reference: 
Travel Medicine and Infectious Disease, Volume 11, Issue 1, January–February 2013, Pages 37-50
MalariaWorld

This paper discusses apparent issues pertaining to the connections between rubber plantations and the populations at high risk for malaria. 

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