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A foci cohort analysis to monitor successful and persistent foci under Thailand’s Malaria Elimination Strategy

March 3, 2021 - 15:43 -- Open Access
Prayuth Sudathip, Suravadee Kitchakarn, Jui A. Shah, Donal Bisanzio, Felicity Young, Deyer Gopinath, Niparueradee Pinyajeerapat, David Sintasath and Cheewanan Lertpiriyasuwat
Malaria Journal 2021 20:118, 27 February 2021

Thailand’s success in reducing malaria burden is built on the efficient “1-3-7” strategy applied to the surveillance system. The strategy is based on rapid case notification within 1 day, case investigation within 3 days, and targeted foci response to reduce the spread of Plasmodium spp. within 7 days. Autochthonous transmission is still occurring in the country, threatening the goal of reaching malaria-free status by 2024. This study aimed to assess the effectiveness of the 1-3-7 strategy and identify factors associated with presence of active foci.

Immunoglobulin G responses to variant forms of Plasmodium vivax merozoite surface protein 9 upon natural infection in Thailand

February 8, 2021 - 10:16 -- Open Access
Songsaigath S, Makiuchi T, Putaporntip C, Pattanawong U, Kuamsab N, Tachibana H, Jongwutiwes S
Sci Rep. 2021 Feb 5;11(1):3201

Merozoite surface protein 9 (MSP9) constitutes a ligand complex involved in erythrocyte invasion by malarial merozoites and is a promising vaccine target. Plasmodium vivax MSP9 (PvMSP9) is immunogenic upon natural malaria exposure. To address whether sequence diversity in PvMSP9 among field isolates could affect natural antibody responses, the recombinant proteins representing two variants each for the N- and the C-terminal domains of PvMSP-9 were used as antigens to assess antibody reactivity among 246 P. vivax-infected patients' sera from Tak and Ubon Ratchathani Provinces in Thailand.

Plasmodium cynomolgi Co-infections among Symptomatic Malaria Patients, Thailand

February 2, 2021 - 16:48 -- Open Access
Putaporntip C, Kuamsab N, Pattanawong U, Yanmanee S, Seethamchai S, Jongwutiwes S
Emerg Infect Dis. 2021 Feb;27(2):590-593

Among 1,180 symptomatic malaria patients, 9 (0.76%) infected with Plasmodium cynomolgi were co-infected with P. vivax (n = 7), P. falciparum (n = 1), or P. vivax and P. knowlesi (n = 1). Patients were from Tak, Chanthaburi, Ubon Ratchathani, Yala, and Narathiwat Provinces, suggesting P. cynomolgi is widespread in this country.

Electrocardiographic effects of four antimalarials for pregnant women with uncomplicated malaria on the Thailand-Myanmar border: a randomised controlled trial

January 27, 2021 - 10:15 -- Open Access
Saito M, Yotyingaphiram W, Cargill Z, Gilder ME, Min AM, Phyo AP, San TD, Poe H, Chu C, White NJ, Nosten F, McGready R
Antimicrob Agents Chemother. 2021 Jan 25:AAC.02473-20

Quinoline antimalarials cause drug-induced electrocardiograph QT prolongation, a potential risk factor for torsade de pointes. The effects of currently used antimalarials on the electrocardiogram were assessed in pregnant women with malaria. Pregnant women with microscopy-confirmed parasitaemia of any malaria species were enrolled in an open-label randomised controlled trial on the Thailand-Myanmar border in 2010-2016. Patients were randomised to the standard regimen dihydroartemisinin-piperaquine (DP), artesunate-mefloquine (ASMQ), or an extended regimen of artemether-lumefantrine (AL+). Recurrent vivax infections were treated with chloroquine. Standard 12-lead electrocardiograms were assessed on day 0, 4-6 hour following the last dose and day 7.

Validation of PfSNP-LAMP-Lateral Flow Dipstick for Detection of Single Nucleotide Polymorphism Associated with Pyrimethamine Resistance in Plasmodium falciparum

November 19, 2020 - 13:33 -- Open Access
Yongkiettrakul S, Kolié FR, Kongkasuriyachai D, Sattabongkot J, Nguitragool W, Nawattanapaibool N, Suansomjit C, Warit S, Kangwanrangsan N, Buates S
Diagnostics (Basel). 2020 Nov 13;10(11):E948

The loop-mediated isothermal amplification coupled with lateral flow dipstick (PfSNP-LAMP-LFD) was recently developed to detect single nucleotide polymorphism (AAT → ATT), corresponding to substitution of asparagine to isoleucine at amino acid position 51 in the P. falciparumdhfr-ts gene associated with antifolate resistance. In this present study, the PfSNP-LAMP-LFD was validated on 128 clinical malaria samples of broad ranged parasite densities (10 to 87,634 parasites per microliter of blood).

Geometric morphometrics to distinguish the cryptic species Anopheles minimus and An. harrisoni in malaria hot spot villages, western Thailand

November 19, 2020 - 13:24 -- Open Access
Chatpiyaphat K, Sumruayphol S, Dujardin JP, Samung Y, Phayakkaphon A, Cui L, Ruangsittichai J, Sungvornyothin S, Sattabongkot J, Sriwichai P
Med Vet Entomol. 2020 Nov 18

Anopheles minimus Theobald 1901 and An. harrisoni Harbach & Manguin 2007 belong to the same species complex. They are morphologically similar and can exist in sympatry but have blood host preferences. The most accurate method for their identification is based on molecular techniques. Here, we measure the level of interspecific discrimination by geometric morphometry.

Seasonal dynamics and molecular differentiation of three natural Anopheles species (Diptera: Culicidae) of the Maculatus group (Neocellia series) in malaria hotspot villages of Thailand

November 14, 2020 - 16:12 -- Open Access
Sumruayphol S, Chaiphongpachara T, Samung Y, Ruangsittichai J, Cui L, Zhong D, Sattabongkot J, Sriwichai P
Parasit Vectors. 2020 Nov 11;13(1):574

Anopheles sawadwongporni Rattanarithikul & Green, Anopheles maculatus Theobald and Anopheles pseudowillmori (Theobald) of the Anopheles maculatus group (Diptera: Culicidae) are recognized as potential malaria vectors in many countries from the Indian subcontinent through Southeast Asia to Taiwan. A number of malaria vectors in malaria hotspot areas along the Thai-Myanmar border belong to this complex. However, the species distribution and dynamic trends remain understudied in this malaria endemic region.

NOT Open Access | Field Evaluation of a Spatial Repellent Emanation Vest for Personal Protection Against Outdoor Biting Mosquitoes

October 21, 2020 - 09:36 -- NOT Open Access
Sukkanon C, Tisgratog R, Muenworn V, Bangs MJ, Hii J, Chareonviriyaphap T
J Med Entomol. 2020 Oct 20:tjaa213

Exophilic vectors are an important contributor to residual malaria transmission. Wearable spatial repellents (SR) can potentially provide personal protection in early evening hours before people retire indoors. An SR prototype for passive delivery of transfluthrin (TFT) for protecting humans against nocturnal mosquitoes in Kanchanaburi, western Thailand, is evaluated. A plastic polyethylene terephthalate (PET) sheet (676 cm2) treated with 55-mg TFT (TFT-PET), attached to the back of short-sleeve vest worn by human collector, was evaluated under semifield and outdoor conditions.

Species diversity and insecticide resistance within the Anopheles hyrcanus group in Ubon Ratchathani Province, Thailand

October 21, 2020 - 08:25 -- Open Access
Sumarnrote A, Overgaard HJ, Corbel V, Thanispong K, Chareonviriyaphap T, Manguin S
Parasit Vectors. 2020 Oct 17;13(1):525

Members of the Anopheles hyrcanus group have been incriminated as important malaria vectors. This study aims to identify the species and explore the insecticide susceptibility profile within the Anopheles hyrcanus group in Ubon Ratchathani Province, northeastern Thailand where increasing numbers of malaria cases were reported in 2014.

Malaria parasites in macaques in Thailand: stump-tailed macaques (Macaca arctoides) are new natural hosts for Plasmodium knowlesi, Plasmodium inui, Plasmodium coatneyi and Plasmodium fieldi

October 6, 2020 - 12:39 -- Open Access
Wirasak Fungfuang, Chanya Udom, Daraka Tongthainan, Khamisah Abdul Kadir and Balbir Singh
Malaria Journal 2020 19:350, 1 October 2020

Certain species of macaques are natural hosts of Plasmodium knowlesi and Plasmodium cynomolgi, which can both cause malaria in humans, and Plasmodium inui, which can be experimentally transmitted to humans. A significant number of zoonotic malaria cases have been reported in humans throughout Southeast Asia, including Thailand. There have been only two studies undertaken in Thailand to identify malaria parasites in non-human primates in 6 provinces. The objective of this study was to determine the prevalence of P. knowlesi, P. cynomolgi, P. inui, Plasmodium coatneyi and Plasmodium fieldi in non-human primates from 4 new locations in Thailand.


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