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Plasmodium ovale

NOT Open Access | Prevalence of Glucose 6-Phosphate Dehydrogenase Variants in Malaria-Endemic Areas of South Central Timor, Eastern Indonesia

July 1, 2020 - 16:33 -- NOT Open Access
Sulistyaningrum N, Arlinda D, Chaijaroenkul W, et al.
Am J Trop Med Hyg. 2020 Jun 29

Primaquine is an effective anti-hypnozoite drug for Plasmodium vivax and Plasmodium ovale. However, it can trigger erythrocyte hemolysis in people with glucose 6-phosphate dehydrogenase (G6PD) deficiency. In a previous report from South Central Timor (SCT), Indonesia, we described the prevalence of Vanua Lava, Chatham, and Viangchan variants; in this study, other G6PD variants (Kaiping, Coimbra, Gaohe, Canton, and Mahidol) were subsequently analyzed. For clarity, all of these results are described together.

Estimating the Proportion of Plasmodium vivax Recurrences Caused by Relapse: A Systematic Review and Meta-Analysis

June 15, 2020 - 15:06 -- Open Access
Commons RJ, Simpson JA, Watson J, White NJ, Price RN
Am J Trop Med Hyg. 2020 Jun 8

Plasmodium vivax and Plasmodium ovale form dormant liver hypnozoites that can reactivate weeks to months following initial infection. Malaria recurrences caused by relapses are an important cause of morbidity and source of transmission. To estimate the proportions of P. vivax malaria recurrences caused by relapses in different geographical locations, we systematically reviewed clinical efficacy studies of uncomplicated P. vivax malaria, in which patients were randomized to treatment with or without radical cure primaquine regimens and were followed up for 1 year.

Immunogenicity analysis of conserved fragments in Plasmodium ovale species merozoite surface protein 4

March 31, 2020 - 15:25 -- Open Access
Juliette Uwase, Ruilin Chu, Kokouvi Kassegne, Yao Lei, Feihu Shen, Haitian Fu, Yifan Sun, Yinghua Xuan, Jun Cao and Yang Cheng
Malaria Journal 2020 19:126, 30 March 2020

There is an urgent need for an effective vaccine to control and eradicate malaria, one of the most serious global infectious diseases. Plasmodium merozoite surface protein 4 (MSP4) has been listed as a blood-stage subunit vaccine candidate for malaria. Infection with Plasmodium ovale species including P. ovale wallikeri and P. ovale curtisi, is also a source of malaria burden in tropical regions where it is sometimes mixed with other Plasmodium species. However, little is known about P. ovale MSP4.

A comparison of two PCR protocols for the differentiation of Plasmodium ovale species and implications for clinical management in travellers returning to Germany: a 10-year cross-sectional study

August 13, 2019 - 15:44 -- Open Access
Hagen Frickmann, Christine Wegner, Stefanie Ruben, Ulrike Loderstädt and Egbert Tannich
Malaria Journal 2019 18:272, 9 August 2019

To assess the occurrence of Plasmodium ovale wallikeri and Plasmodium ovale curtisi species in travellers returning to Germany, two real-time PCR protocols for the detection and differentiation of the two P. ovale species were compared. Results of parasite differentiation were correlated with patient data.

A cluster of the first reported Plasmodium ovale spp. infections in Peru occuring among returning UN peace-keepers, a review of epidemiology, prevention and diagnostic challenges in nonendemic regions

May 24, 2019 - 16:08 -- Open Access
Rosio I. Guerra, Marianela Ore, Hugo O. Valdivia, Danett K. Bishop, Mariana Ramos, Christopher N. Mores and Wesley R. Campbell
Malaria Journal 2019 18:176, 22 May 2019

Plasmodium ovale curtisi and Plasmodium ovale wallikeri are regarded as less virulent forms of malaria with a geographic distribution including Southeast Asia, Central and West Africa, and is increasingly reported as an infection in returning travellers. A species of malaria that may have delayed or relapsing presentations similar to Plasmodium vivax, the clinical presentation of P. ovale spp. has been described to have prepatent periods of 2 weeks or slightly longer with reports of relapse following primary infection out to 8–9 months. This presentation may be obscured further in the setting of anti-malarial exposure, with report of delayed primary infection out to 4 years. Presented is a cluster of 4 imported P. ovale spp. cases in returning Peruvian military personnel assigned to United Nations peace-keeping operations in the Central African Republic.


Assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for Plasmodium ovale detection

March 28, 2019 - 15:55 -- Open Access
Jianxia Tang, Feng Tang, Hongru Zhu, Feng Lu, Sui Xu, Yuanyuan Cao, Yaping Gu, Xiaoqin He, Huayun Zhou, Guoding Zhu, Jun Cao
PLoS Negl Trop Dis 13(3): e0007254

Currently, malaria rapid diagnostic tests (RDTs) are widely used for malaria diagnosis, but test performance and the factors that lead to failure of Plasmodium ovale detection are not well understood.

Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections

October 31, 2018 - 15:34 -- Open Access
Gerardo Rojo-Marcos, José Miguel Rubio-Muñoz, José Llovo‑Taboada, et al.
Malaria Journal 2018 17:399, 30 October 2018

Imported P. o. wallikeri infection may be more frequent in males and Caucasians.

Medical Treatment: 

Severe Plasmodium ovale malaria complicated by acute respiratory distress syndrome in a young Caucasian man

April 3, 2018 - 15:14 -- Open Access
Alessandra D’Abramo, Saba Gebremeskel Tekle, Marco Iannetta, Laura Scorzolini, Alessandra Oliva, Maria Grazia Paglia, Angela Corpolongo and Emanuele Nicastri
Malaria Journal 2018 17:139, 2 April 2018

Ovale malaria is usually considered a tropical infectious disease associated with low morbidity and mortality. However, severe disease and death have occasionally been reported.

Polymorphisms analysis of the Plasmodium ovale tryptophan-rich antigen gene (potra) from imported malaria cases in Henan Province

March 27, 2018 - 15:43 -- Open Access
Ruimin Zhou, Ying Liu, Bianli Xu, et al.
Malaria Journal 2018 17:127, 23 March 2018

This study further proved that more fragment sizes were found, P. o. wallikeri had six sizes, P. o. curtisi had four sizes.

Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection

February 13, 2018 - 15:50 -- Open Access
Luzia Veletzky, Mirjam Groger, Heimo Lagler, Julia Walochnik, Herbert Auer, Hans-Peter Fuehrer and Michael Ramharter
Malaria Journal 2018 17:78, 9 February 2018

Conclusive evidence for relapses with P. ovale spp. is rare.


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