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sulphadoxine-pyrimethamine

High prevalence of pfcrt-CVIET haplotype in isolates from asymptomatic and symptomatic patients in south-central Oromia, Ethiopia

April 10, 2014 - 17:37 -- Open Access
Author(s): 
Golassa L, Enweji N, Erko B, Aseffa A, Swedberg G
Reference: 
Malaria Journal 2014, 13 :120 (27 March 2014)

The presence of K76T mutations was determined using nested PCR for all isolates. Complete sequencing of mutations in pfcrt 72-76 was done for a set of randomly selected resistant isolates.

Factors affecting uptake of optimal doses of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy in six districts of Tanzania

January 22, 2014 - 14:09 -- Open Access
Author(s): 
Exavery A, Mbaruku G, Mbuyita S, Makemba A, Kinyonge IP, Kweka H
Reference: 
Malaria Journal 2014, 13 :22 (14 January 2014)

This study assesses the extent and predictors of uptake of optimal doses of IPTp-SP in six districts of Tanzania.

Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan

July 23, 2013 - 16:48 -- Open Access
Author(s): 
Gadalla NB, Abdallah TM, Atwal S, Sutherland CJ, Adam I
Reference: 
Malaria Journal 2013, 12:255 (19 July 2013)
MalariaWorld

In this study, an evaluation of the efficacy and prevalence of drug resistance alleles (pfcrt, pfmdr1, pfdhfr and pfdhps) eight years after the adoption of AS/SP in eastern Sudan is reported.

A clinical and molecular study of artesunate + sulphadoxine-pyrimethamine in three districts of central and eastern India

July 22, 2013 - 18:00 -- Open Access
Author(s): 
Srivastava P, Ratha J, Shah NK, Mishra N, Anvikar AK, Sharma SK, Das MK, Srivastava B, Valecha N
Reference: 
Malaria Journal 2013, 12:247 (17 July 2013)
MalariaWorld

The study was undertaken in three high endemic sites of central and eastern India. Patients with uncomplicated falciparum malaria were enrolled and followed for 28 days.

High prevalence of mutation in the Plasmodium falciparum dhfr and dhps genes in field isolates from Sabah, Northern Borneo

June 20, 2013 - 16:55 -- Open Access
Author(s): 
Abdullah N, Norahmad N, Jelip J, Sulaiman L, Mohd Sidek H, Ismail Z, Noedl H
Reference: 
Malaria Journal 2013, 12:198 (12 June 2013)
MalariaWorld

The data suggest a high prevalence of genetic variations conferring resistance to SP which can predict treatment failure before becoming clinically evident. In areas like this, the use of SP may no longer be indicated.

Changing the malaria treatment protocol policy in Timor-Leste: an examination of context, process, and actors' involvement

May 22, 2013 - 15:15 -- Open Access
Author(s): 
João S Martins, Anthony B Zwi, Karen Hobday, Fernando Bonaparte and Paul M Kelly
Reference: 
Health Research Policy and Systems 2013, 11:16
MalariaWorld

This paper examines the challenges and opportunities identified during this period of treatment protocol change.

Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea

April 2, 2013 - 13:43 -- Open Access
Author(s): 
Mendes C, Salgueiro P, Gonzalez V, Berzosa P, Benito A, do Rosário VE, de Sousa B, Cano J, Arez A
Reference: 
Malaria Journal 2013, 12:114 (27 March 2013)
MalariaWorld

This study aimed to characterize the circulating populations of Plasmodium spp and Plasmodium falciparum from a combined set of human blood and mosquito samples gathered in mainland Equatorial Guinea.

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