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Uptake of intermittent preventive treatment for malaria during pregnancy with Sulphadoxine-Pyrimethamine in Malawi after adoption of updated World Health Organization policy: an analysis of demographic and health survey 2015-2016

March 19, 2020 - 08:50 -- Open Access
Azizi SC
BMC Public Health. 2020 Mar 16; 20(1):335

Malawi adopted the 2012 updated Word Health Organization (WHO) Intermittent preventive treatment of malaria during pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) policy in 2013. This study aimed to estimate the proportion of and identify factors associated with the uptake of at least three doses of IPTp with SP among pregnant women in Malawi after the adoption and operationalisation of updated WHO IPTp-SP policy.

Efficacy of sulphadoxine-pyrimethamine + artesunate, sulphadoxine-pyrimethamine + amodiaquine, and sulphadoxine-pyrimethamine alone in uncomplicated falciparum malaria in Mali

March 10, 2015 - 14:01 -- Open Access
Hamma Maiga, Abdoulaye A Djimde, Ogobara K Doumbo, et al.
Malaria Journal 2015, 14:64 (7 February 2015)

Sulphadoxine-pyrimethamine + amodiaquine therapy was as efficacious as sulphadoxine-pyrimethamine + artesunate, but more efficacious than sulphadoxine-pyrimethamine alone in the treatment of uncomplicated P. falciparum malaria in Mali.

Uptake of intermittent preventive treatment with sulphadoxine-pyrimethamine for malaria during pregnancy and pregnancy outcomes: a cross-sectional study in Geita district, North-Western Tanzania

December 5, 2014 - 07:24 -- Open Access
Filbert J Mpogoro, Dismas Matovelo, Aliyah Dosani, Sospatro Ngallaba, Moshi Mugono, Humphrey D Mazigo
Malaria Journal 2014, 13:455 (24 November 2014)

A cross-sectional study was conducted among singleton pregnant women who delivered in two selected health facilities of Geita district, northwestern Tanzania.

Not Open Access | Mefloquine Not an Alternative for Treating Malaria in Pregnant Women

November 18, 2014 - 18:37 -- NOT Open Access
M. J. Friedrich
JAMA. 2014;312(19):1961

Finding an alternative to sulphadoxine-pyrimethamine has become a concern because of an increase in malaria parasite resistance to sulphadoxine-pyrimethamine. In addition, sulphadoxine-pyrimethamine is contraindicated in women who are HIV-positive because it interacts negatively with the HIV drug cotrimoxazole.


Clinical malaria among pregnant women on combined insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp) with sulphadoxine-pyrimethamine in Yaounde, Cameroon

May 28, 2014 - 17:53 -- Open Access
Mbu R, Takang W, Fouedjio H, Fouelifack F, Tumasang F, Tonye R
BMC Women's Health 2014,14:68(16 May 2014)

We compared the socio-obstetrical characteristics of women who developed clinical malaria and those who did not though in the same regimen.


Two novel mutations of pfdhps K540T and I588F, affecting sulphadoxine-pyrimethamine-resistant response in uncomplicated falciparum malaria at Banjar district, South Kalimantan Province, Indonesia

April 16, 2014 - 18:52 -- Open Access
Basuki S, Fitriah, Riyanto S, Budiono, Dachlan YP, Uemura H
Malaria Journal 2014, 13 :135 (4 April 2014)

Pfdhfr and pfdhps genotypes from 24 P. falciparum-infected patients consisting of adequate clinical parasitological response (ACPR) (n = 6; 25.0%) and early treatment failure (ETF) (n = 10; 41.7%) or late parasitological failure (LPF) (n = 8; 33.3%) were obtained by sequencing.


High prevalence of pfcrt-CVIET haplotype in isolates from asymptomatic and symptomatic patients in south-central Oromia, Ethiopia

April 10, 2014 - 17:37 -- Open Access
Golassa L, Enweji N, Erko B, Aseffa A, Swedberg G
Malaria Journal 2014, 13 :120 (27 March 2014)

The presence of K76T mutations was determined using nested PCR for all isolates. Complete sequencing of mutations in pfcrt 72-76 was done for a set of randomly selected resistant isolates.

Factors affecting uptake of optimal doses of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy in six districts of Tanzania

January 22, 2014 - 14:09 -- Open Access
Exavery A, Mbaruku G, Mbuyita S, Makemba A, Kinyonge IP, Kweka H
Malaria Journal 2014, 13 :22 (14 January 2014)

This study assesses the extent and predictors of uptake of optimal doses of IPTp-SP in six districts of Tanzania.

Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan

July 23, 2013 - 16:48 -- Open Access
Gadalla NB, Abdallah TM, Atwal S, Sutherland CJ, Adam I
Malaria Journal 2013, 12:255 (19 July 2013)

In this study, an evaluation of the efficacy and prevalence of drug resistance alleles (pfcrt, pfmdr1, pfdhfr and pfdhps) eight years after the adoption of AS/SP in eastern Sudan is reported.

A clinical and molecular study of artesunate + sulphadoxine-pyrimethamine in three districts of central and eastern India

July 22, 2013 - 18:00 -- Open Access
Srivastava P, Ratha J, Shah NK, Mishra N, Anvikar AK, Sharma SK, Das MK, Srivastava B, Valecha N
Malaria Journal 2013, 12:247 (17 July 2013)

The study was undertaken in three high endemic sites of central and eastern India. Patients with uncomplicated falciparum malaria were enrolled and followed for 28 days.


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