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sulphadoxine-pyrimethamine

Impact of Health Systems on the Implementation of Intermittent Preventive Treatment for Malaria in Pregnancy in Sub-Saharan Africa: A Narrative Synthesis

August 27, 2020 - 08:07 -- Open Access
Author(s): 
Olaleye AO, Walker O
Reference: 
Trop Med Infect Dis. 2020 Aug 22;5(3):E134

Malaria in pregnancy is a public health challenge with serious negative maternal and newborn consequences. Intermittent preventive treatment (IPTp) with sulphadoxine-pyrimethamine is recommended for the control of malaria during pregnancy within endemic areas, but coverage for the recommended ≥3 doses IPTp regimen has remained suboptimal. We searched PubMed, Cochrane library, and HINARI database from 1 January 2010 to 23 May 2020, for studies investigating the effect of the health system on IPTp implementation.

NOT Open Access | Analysis of sulphadoxine-pyrimethamine resistance-associated mutations in Plasmodium falciparum isolates obtained from asymptomatic pregnant women in Ogun State, Southwest Nigeria

August 19, 2020 - 09:17 -- NOT Open Access
Author(s): 
Fagbemi KA, Adebusuyi SA, Nderu D, Adedokun SA, Pallerla SR, Amoo AOJ, Thomas BN, Velavan TP, Ojurongbe O
Reference: 
Infect Genet Evol. 2020 Aug 14:104503

Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) is one of the main strategies for protecting pregnant women, fetus, and their new-born against adverse effects of P. falciparum infection. The development of the drug resistance linked to mutations in P. falciparum dihydrofolate reductase gene (pfdhfr) and P. falciparum dihydropteroate synthase gene (pfdhps), is currently threatening the IPTp-SP approach.

High multiple mutations of Plasmodium falciparum-resistant genotypes to sulphadoxine-pyrimethamine in Lagos, Nigeria

July 14, 2020 - 15:34 -- Open Access
Author(s): 
Quan H, Igbasi U, Oyibo W, Omilabu S, Chen SB, Shen HM, Okolie C, Chen JH, Zhou XN
Reference: 
Infect Dis Poverty. 2020 Jul 11; 9(1):91

Plasmodium falciparum-resistance to sulphadoxine-pyrimethamine (SP) has been largely reported among pregnant women. However, the profile of resistance markers to SP dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) in the general population are varied and not frequently monitored. Currently, SP is used as partner drug for artemisinin combination therapy (SP-artesunate) in some sub-Saharan African countries or as a prophylactic drug in intermittent preventive treatment of malaria during pregnancy and infants and in seasonal malaria chemoprevention (SMC). Profiling of P. falciparum-resistant genotypes to SP is dynamic and critical in providing data that would be useful for malaria control programmes. This study assessed the profile of dhfr and dhps genes genotypes among individuals with malaria in Lagos, Nigeria.

Uptake of intermittent preventive treatment for malaria during pregnancy with Sulphadoxine-Pyrimethamine in Malawi after adoption of updated World Health Organization policy: an analysis of demographic and health survey 2015-2016

March 19, 2020 - 08:50 -- Open Access
Author(s): 
Azizi SC
Reference: 
BMC Public Health. 2020 Mar 16; 20(1):335

Malawi adopted the 2012 updated Word Health Organization (WHO) Intermittent preventive treatment of malaria during pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) policy in 2013. This study aimed to estimate the proportion of and identify factors associated with the uptake of at least three doses of IPTp with SP among pregnant women in Malawi after the adoption and operationalisation of updated WHO IPTp-SP policy.

Efficacy of sulphadoxine-pyrimethamine + artesunate, sulphadoxine-pyrimethamine + amodiaquine, and sulphadoxine-pyrimethamine alone in uncomplicated falciparum malaria in Mali

March 10, 2015 - 14:01 -- Open Access
Author(s): 
Hamma Maiga, Abdoulaye A Djimde, Ogobara K Doumbo, et al.
Reference: 
Malaria Journal 2015, 14:64 (7 February 2015)

Sulphadoxine-pyrimethamine + amodiaquine therapy was as efficacious as sulphadoxine-pyrimethamine + artesunate, but more efficacious than sulphadoxine-pyrimethamine alone in the treatment of uncomplicated P. falciparum malaria in Mali.

Uptake of intermittent preventive treatment with sulphadoxine-pyrimethamine for malaria during pregnancy and pregnancy outcomes: a cross-sectional study in Geita district, North-Western Tanzania

December 5, 2014 - 07:24 -- Open Access
Author(s): 
Filbert J Mpogoro, Dismas Matovelo, Aliyah Dosani, Sospatro Ngallaba, Moshi Mugono, Humphrey D Mazigo
Reference: 
Malaria Journal 2014, 13:455 (24 November 2014)

A cross-sectional study was conducted among singleton pregnant women who delivered in two selected health facilities of Geita district, northwestern Tanzania.

Not Open Access | Mefloquine Not an Alternative for Treating Malaria in Pregnant Women

November 18, 2014 - 18:37 -- NOT Open Access
Author(s): 
M. J. Friedrich
Reference: 
JAMA. 2014;312(19):1961

Finding an alternative to sulphadoxine-pyrimethamine has become a concern because of an increase in malaria parasite resistance to sulphadoxine-pyrimethamine. In addition, sulphadoxine-pyrimethamine is contraindicated in women who are HIV-positive because it interacts negatively with the HIV drug cotrimoxazole.

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Clinical malaria among pregnant women on combined insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp) with sulphadoxine-pyrimethamine in Yaounde, Cameroon

May 28, 2014 - 17:53 -- Open Access
Author(s): 
Mbu R, Takang W, Fouedjio H, Fouelifack F, Tumasang F, Tonye R
Reference: 
BMC Women's Health 2014,14:68(16 May 2014)

We compared the socio-obstetrical characteristics of women who developed clinical malaria and those who did not though in the same regimen.

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Two novel mutations of pfdhps K540T and I588F, affecting sulphadoxine-pyrimethamine-resistant response in uncomplicated falciparum malaria at Banjar district, South Kalimantan Province, Indonesia

April 16, 2014 - 18:52 -- Open Access
Author(s): 
Basuki S, Fitriah, Riyanto S, Budiono, Dachlan YP, Uemura H
Reference: 
Malaria Journal 2014, 13 :135 (4 April 2014)

Pfdhfr and pfdhps genotypes from 24 P. falciparum-infected patients consisting of adequate clinical parasitological response (ACPR) (n = 6; 25.0%) and early treatment failure (ETF) (n = 10; 41.7%) or late parasitological failure (LPF) (n = 8; 33.3%) were obtained by sequencing.

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High prevalence of pfcrt-CVIET haplotype in isolates from asymptomatic and symptomatic patients in south-central Oromia, Ethiopia

April 10, 2014 - 17:37 -- Open Access
Author(s): 
Golassa L, Enweji N, Erko B, Aseffa A, Swedberg G
Reference: 
Malaria Journal 2014, 13 :120 (27 March 2014)

The presence of K76T mutations was determined using nested PCR for all isolates. Complete sequencing of mutations in pfcrt 72-76 was done for a set of randomly selected resistant isolates.

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