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MMV

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

January 12, 2021 - 14:50 -- Open Access
Author(s): 
Reader J, van der Watt ME, Birkholtz LM, et al.
Reference: 
Nat Commun. 2021 Jan 11;12(1):269

Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response Box against Plasmodium asexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. Unique chemotypes were identified with both multistage activity or stage-specific activity, including structurally diverse gametocyte-targeted compounds with potent transmission-blocking activity, such as the JmjC inhibitor ML324 and the antitubercular clinical candidate SQ109.

Not Open Access | Screening Malaria-box compounds to identify potential inhibitors against SARS-CoV-2 M(pro), using molecular docking and dynamics simulation studies

January 7, 2021 - 10:07 -- NOT Open Access
Author(s): 
Ahamad S, Kanipakam H, Birla S, Ali MS, Gupta D
Reference: 
Eur J Pharmacol. 2021 Jan 5;890:173664

Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) Main protease (Mpro) is one of the vital drug targets amongst all the coronaviruses, as the protein is indispensable for virus replication. The study aimed to identify promising lead molecules against Mpro enzyme through virtual screening of Malaria Venture (MMV) Malaria Box (MB) comprising of 400 experimentally proven compounds.

Photo Contest - Malaria: The BIG Picture

February 17, 2013 - 21:32 -- Bart G.J. Knols

 

Malaria affects the lives of millions across the world. The Swiss Malaria Group* online photo contest seeks to highlight the realities of those living at risk of malaria and the work of those dedicated to changing that reality.
 
The contest is open to all. Send in your photos and captions that tell a story about malaria between 15 February and 24 March via the competition website, where you will find details of the three submission categories. The public will then vote to determine the finalists and a panel of expert judges will select the winners.
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