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Correlates of uptake of optimal doses of sulfadoxine-pyrimethamine for prevention of malaria during pregnancy in East-Central Uganda

April 18, 2020 - 13:55 -- Open Access
Mbonye K. Martin, Kirwana B. Venantius, Ndugga Patricia, Kikaire Bernard, Baleeta Keith, Kabagenyi Allen, Asiimwe Godfrey, Twesigye Rogers, Kadengye T. Damazo and Byonanebye M. Dathan
Malaria Journal 2020 19:153, 15 April 2020

In 2012, the World Health Organization recommended that pregnant women in malaria-endemic countries complete at least three (optimal) doses of intermittent preventive treatment (IPTp) using sulfadoxine-pyrimethamine (SP) to prevent malaria and related adverse events during pregnancy. Uganda adopted this recommendation, but uptake remains low in East-Central and information to explain this low uptake remains scanty. This analysis determined correlates of uptake of optimal doses of IPTp-SP in East-Central Uganda.

NOT Open Access | Interactions between antenatal sulfadoxine-pyrimethamine, drug-resistant Plasmodium falciparum parasites and delivery outcomes in Malawi

March 30, 2020 - 10:21 -- NOT Open Access
Taylor SM, Levitt B, Freedman B, Madanitsa M, Thwai KL, Kalilani-Phiri L, Khairallah C, Mwapasa V, Ter Kuile FO, Meshnick SR
J Infect Dis. 2020 Mar 28. pii: jiaa145

Sulfadoxine-pyrimethamine (SP) is used as intermittent preventive therapy in pregnancy (IPTp) for malaria in sub-Saharan Africa. The resistance marker dhps A581G has been associated with reduced IPTp-SP efficacy and enhanced morbidity in SP-recipients.

Effectiveness of Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria and Adverse Birth Outcomes in Pregnant Women

March 18, 2020 - 14:43 -- Open Access
Mlugu EM, Minzi O, Asghar M, Färnert A, Kamuhabwa AAR, Aklillu E
Pathogens. 2020 Mar 11;9(3). pii: E207

Effectiveness of intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine (IPTp-SP) for prevention of malaria and adverse birth outcomes can be compromised by parasites-resistance to sulfadoxine–pyrimethamine. This study prospectively evaluated the effectiveness of IPTp-SP in Southeast Tanzania. From January 2017 to May 2019, HIV-negative and malaria-negative (mRDT) pregnant women attending their first antenatal-care visit in the second or third trimester (n = 500) were enrolled to receive monthly IPTp-SP and followed the protocol till delivery.

Factors influencing adherence to the new intermittent preventive treatment of malaria in pregnancy policy in Keta District of the Volta region, Ghana

November 26, 2019 - 20:37 -- Open Access
Alren O. Vandy, Nana Yaw Peprah, Joseph Yaw Jerela, Perfect Titiati, Abubakar Manu, Joseph Akamah, Ernest T. Maya & Kwasi Torpey
BMC Pregnancy and Childbirth volume 19, Article number: 424 (2019)

About 25% of pregnant women in malaria-endemic areas are infected with malaria and this accounts for about 15% of maternal deaths globally. Intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) is one of the main strategies for prevention of malaria in pregnancy. A new recommendation was made by the World Health Organization (WHO) that at least three doses of IPTp-SP should be administered before delivery. This study sought to determine the factors influencing adherence to the new IPTp-SP policy in Keta District, Volta region, Ghana.


Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Negative Women: A Multicentre Randomized Controlled Trial

October 1, 2014 - 18:07 -- Open Access
Raquel González, Ghyslain Mombo-Ngoma, Clara Menéndez, et al.
PLoS Med 11(9): e1001733.

A total of 4,749 pregnant women were enrolled in an open-label randomized clinical trial conducted in Benin, Gabon, Mozambique, and Tanzania comparing two-dose MQ or SP for IPTp and MQ tolerability of two different regimens.

Not Open Access | Acknowledging HIV and malaria as major causes of maternal mortality in Mozambique

September 10, 2014 - 16:56 -- NOT Open Access
Kavita Singh, Allisyn Moran, William Story, Patricia Bailey, Leonardo Chavane
International Journal of Gynecology & Obstetrics, Volume 127, Issue 1, October 2014, Pages 35-40

To review national data on HIV and malaria as causes of maternal death and to determine the importance of looking at maternal mortality at a subnational level in Mozambique.

Progress toward elimination of malaria in Nigeria: Uptake of artemisinin-based combination therapies for the treatment of malaria in households in Benin City.

June 17, 2014 - 17:30 -- Open Access
Akoria OA, Arhuidese IJ
Ann Afr Med. 2014 Jul-Sep;13(3):104-13

 Multistage sampling technique was used to select households from each of the three local government areas in Benin City. Adult respondents were interviewed. Household reference persons (HRPs) were defined by International Labour Organization categories

Not Open Access | Ordered Accumulation of Mutations Conferring Resistance to Sulfadoxine-Pyrimethamine in the Plasmodium falciparum Parasite

December 17, 2013 - 19:08 -- NOT Open Access
Toshihiro Mita, Jun Ohashi, Meera Venkatesan, Aung Swi Prue Marma, Masatoshi Nakamura, Christopher V. Plowe and Kazuyuki Tanabe
J Infect Dis. (2014) 209 (1): 130-139.

We investigated the order of step-wise accumulation in dhfr and dhps by cumulative analyses using binomial tests in 575 P. falciparum isolates obtained from 7 countries in Asia and Melanesia.

Not Open Access | Intermittent Preventive Therapy for Malaria During Pregnancy Using 2 vs 3 or More Doses of Sulfadoxine-Pyrimethamine and Risk of Low Birth Weight in Africa. Systematic Review and Meta-analysis.

February 14, 2013 - 15:20 -- NOT Open Access
Kassoum Kayentao, Paul Garner, Feiko O. ter Kuile, et al.
Journal Of American Medical Association, February 13, 2013, Vol 309, No. 6


Intermittent preventive therapy with sulfadoxine-pyrimethamine to control malaria during pregnancy is used in 37 countries in sub-Saharan Africa, and 31 of those countries use the standard 2-dose regimen. However, 2 doses may not provide protection during the last 4 to 10 weeks of pregnancy, a pivotal period for fetal weight gain.



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