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sulfadoxine-pyrimethamine

NOT Open Access | Evaluation of the usefulness of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine in a context with increased resistance of Plasmodium falciparum in Kingasani Hospital, Kinshasa in the Democratic Re

July 21, 2021 - 18:04 -- NOT Open Access
Author(s): 
Kalenda NK, Yobi DM, Speybroeck N, et al.
Reference: 
Infect Genet Evol. 2021 Jul 17:105009

Increasing resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) threatens its usefulness for intermittent preventive treatment in pregnancy (IPTp-SP). The prophylactic effects of IPTp-SP on maternal malaria and adverse pregnancy outcomes were evaluated in Kingasani Hospital, Kinshasa in the Democratic Republic of Congo (DRC).

Not Open Access | The effect of intermittent preventive treatment of malaria during pregnancy and placental malaria on infant risk of malaria

July 6, 2021 - 14:33 -- NOT Open Access
Author(s): 
Andronescu LR, Sharma A, Peterson I, Kachingwe M, Kachepa W, Liang Y, Gutman JR, Mathanga DP, Chinkhumba J, Laufer MK
Reference: 
J Infect Dis. 2021 Jul 3:jiab351

Intermittent preventive treatment of malaria during pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) provides greater protection from placental malaria than sulfadoxine-pyrimethamine (SP). Some studies suggest placental malaria alters the risk of malaria infection in infants, but few studies have quantified the effect of IPTp on infant susceptibility to malaria.

NOT Open Access | Geographical spread and structural basis of sulfadoxine-pyrimethamine drug-resistant malaria parasites

March 31, 2021 - 14:48 -- NOT Open Access
Author(s): 
Chaturvedi R, Chhibber-Goel J, Verma I, Gopinathan S, Parvez S, Sharma A
Reference: 
Int J Parasitol. 2021 Mar 25:S0020-7519(21)00113-2

The global spread of sulfadoxine (Sdx, S) and pyrimethamine (Pyr, P) resistance is attributed to increasing number of mutations in DHPS and DHFR enzymes encoded by malaria parasites. The association between drug resistance mutations and SP efficacy is complex. Here we provide an overview of the geographical spread of SP resistance mutations in Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) encoded dhps and dhfr genes.

NOT Open Access | Effectiveness of intermittent preventive treatment with Sulfadoxine-Pyrimethamine in pregnant women in San Pedro, Côte D'Ivoire

March 30, 2021 - 14:24 -- NOT Open Access
Author(s): 
Bedia-Tanoh AV, Konaté A, Yavo W, et al.
Reference: 
Pathog Glob Health. 2021 Mar 26:1-6

Malaria remains a major public health issue for pregnant women. Côte d'Ivoire has adopted a series of measures aimed at combatting this plague, and these measures include administering Sulfadoxine-Pyrimethamine (SP) as an intermittent preventive treatment to pregnant women in the second and third terms.This cross-sectional study included a parturient population after informed written consent. We recruited women from the Terre Rouge maternity ward and the labor room of the Regional Medical Center of San-Pedro.

Temporal evolution of sulfadoxine-pyrimethamine resistance genotypes and genetic diversity in response to a decade of increased interventions against Plasmodium falciparum in northern Ghana

March 18, 2021 - 09:27 -- Open Access
Author(s): 
Lucas N. Amenga-Etego, Victor Asoala, Godfred Agongo, Christopher Jacob, Sonia Goncalves, Gordon A. Awandare, Kirk A. Rockett and Dominic Kwiatkowski
Reference: 
Malaria Journal 2021 20:152, 17 March 2021

Anti-malarial drug resistance remains a key concern for the global fight against malaria. In Ghana sulfadoxine-pyrimethamine (SP) is used for intermittent preventive treatment of malaria in pregnancy and combined with amodiaquine for Seasonal Malaria Chemoprevention (SMC) during the high malaria season. Thus, surveillance of molecular markers of SP resistance is important to guide decision-making for these interventions in Ghana.

Predictors for the uptake of optimal doses of sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria during pregnancy in Tanzania: further analysis of the data of the 2015–2016 Tanzania demographic and health survey and malaria indicat

February 8, 2021 - 10:59 -- Open Access
Author(s): 
Vivian Mushi, Christopher H. Mbotwa, Abdallah Zacharia, Theresia Ambrose and Fabiola V. Moshi
Reference: 
Malaria Journal 2021 20:75, 6 February 2021

In Tanzania, the uptake of optimal doses (≥ 3) of sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria (IPTp-SP) during pregnancy has remained below the recommended target of 80%. Therefore, this study aimed to investigate the predictors for the uptake of optimal IPTp-SP among pregnant women in Tanzania.

Evaluation of health system readiness and coverage of intermittent preventive treatment of malaria in infants (IPTi) in Kambia district to inform national scale-up in Sierra Leone

February 8, 2021 - 10:57 -- Open Access
Author(s): 
Maria Lahuerta, Roberta Sutton, Laura Steinhardt, et al.
Reference: 
Malaria Journal 2021 20:74, 6 February 2021

Intermittent preventive treatment of malaria in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is a proven strategy to protect infants against malaria. Sierra Leone is the first country to implement IPTi nationwide. IPTi implementation was evaluated in Kambia, one of two initial pilot districts, to assess quality and coverage of IPTi services.

Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamine antimalarial drug resistance

January 6, 2021 - 13:10 -- Open Access
Author(s): 
Turkiewicz A, Manko E, Sutherland CJ, Diez Benavente E, Campino S, Clark TG
Reference: 
PLoS Genet. 2020 Dec 31;16(12):e1009268

Plasmodium falciparum parasites resistant to antimalarial treatments have hindered malaria disease control. Sulfadoxine-pyrimethamine (SP) was used globally as a first-line treatment for malaria after wide-spread resistance to chloroquine emerged and, although replaced by artemisinin combinations, is currently used as intermittent preventive treatment of malaria in pregnancy and in young children as part of seasonal malaria chemoprophylaxis in sub-Saharan Africa. The emergence of SP-resistant parasites has been predominantly driven by cumulative build-up of mutations in the dihydrofolate reductase (pfdhfr) and dihydropteroate synthetase (pfdhps) genes, but additional amplifications in the folate pathway rate-limiting pfgch1 gene and promoter, have recently been described.

Reaching the unreached: effectiveness and satisfaction with community-directed distribution of sulfadoxine-pyrimethamine for preventing malaria in pregnancy in rural South-East, Nigeria

November 10, 2020 - 13:58 -- Open Access
Author(s): 
Ijeoma Nkem Okedo-Alex, Ifeyinwa Chizoba Akamike, Chigozie Jesse Uneke, et al.
Reference: 
Malaria Journal 2020 19:394, 7 November 2020

Innovative community strategies to increase intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) coverage is advocated particularly in rural areas, where health infrastructure is weakest and malaria transmission highest. This study involved proof-of-concept implementation research to determine satisfaction with and effectiveness of community-directed distribution of IPTp-SP on uptake among pregnant women in Ebonyi State, Nigeria.

Epidemiology of malaria among pregnant women during their first antenatal clinic visit in the middle belt of Ghana: a cross sectional study

October 27, 2020 - 15:55 -- Open Access
Author(s): 
David Kwame Dosoo, Daniel Chandramohan, Seth Owusu-Agyei, et al.
Reference: 
Malaria Journal 2020 19:381, 23 October 2020

Malaria during pregnancy may result in unfavourable outcomes in both mothers and their foetuses. This study sought to document the current burden and factors associated with malaria and anaemia among pregnant women attending their first antenatal clinic visit in an area of Ghana with perennial malaria transmission.

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