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NOT Open Access | Risk factors for Burkitt lymphoma in East African children and minors: A case-control study in malaria-endemic regions in Uganda, Tanzania and Kenya

February 22, 2020 - 16:29 -- NOT Open Access
Peprah S, Ogwang MD, Kerchan P, Reynolds SJ, Tenge CN, Were PA, Kuremu RT, Wekesa WN, Sumba PO, Masalu N, Kawira E, Magatti J, Kinyera T, Otim I, Legason ID, Nabalende H, Dhudha H, Ally H, Genga IO, Mumia M, Ayers LW, Pfeiffer RM, Biggar RJ, Bhatia K, Goedert JJ, Mbulaiteye SM
Int J Cancer. 2020 Feb 15;146(4):953-969

Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in sub‐Saharan African countries, however, few epidemiologic studies have been undertaken and none attempted enrolling cases from multiple countries. We therefore conducted a population‐based case–control study of eBL in children aged 0–15 years old in six regions in Northern Uganda, Northern Tanzania and Western Kenya, enrolling 862 suspected cases and 2,934 population controls (response rates 98.5–100%), and processing ~40,000 vials of samples using standardized protocols.

Usefulness of day 7 lumefantrine plasma concentration as a predictor of malaria treatment outcome in under-fives children treated with artemether-lumefantrine in Tanzania

February 14, 2020 - 16:51 -- Open Access
Manase Kilonzi, Omary Minzi, Ritah Mutagonda, Vito Baraka, Philip Sasi, Eleni Aklillu and Appolinary Kamuhabwa
Malaria Journal 2020 19:66, 11 February 2020

Day 7 plasma lumefantrine concentration is suggested as a predictor for malaria treatment outcomes and a cut-off of ≥ 200 ng/ml is associated with day 28 cure rate in the general population. However, day 7 lumefantrine plasma concentration can be affected by age, the extent of fever, baseline parasitaemia, and bodyweight. Therefore, this study assessed the usefulness of day 7 lumefantrine plasma concentration as a predictor of malaria treatment outcome in under-fives children treated with generic or innovator drug-containing artemether-lumefantrine (ALu) in Tanzania.

Falciparum malaria from coastal Tanzania and Zanzibar remains highly connected despite effective control efforts on the archipelago

February 3, 2020 - 17:01 -- Open Access
Andrew P. Morgan, Nicholas F. Brazeau, Jonathan J. Juliano, et al.
Malaria Journal 2020 19:47, 28 January 2020

Tanzania’s Zanzibar archipelago has made significant gains in malaria control over the last decade and is a target for malaria elimination. Despite consistent implementation of effective tools since 2002, elimination has not been achieved. Importation of parasites from outside of the archipelago is thought to be an important cause of malaria’s persistence, but this paradigm has not been studied using modern genetic tools.

Preferred resting surfaces of dominant malaria vectors inside different house types in rural south-eastern Tanzania

January 20, 2020 - 15:37 -- Open Access
Betwel J. Msugupakulya, Emmanuel W. Kaindoa, Halfan S. Ngowo, Japhet M. Kihonda, Najat F. Kahamba, Dickson S. Msaky, Damaris Matoke-Muhia, Patrick K. Tungu and Fredros O. Okumu
Malaria Journal 2020 19:22, 15 January 2020

Malaria control in Africa relies extensively on indoor residual spraying (IRS) and insecticide-treated nets (ITNs). IRS typically targets mosquitoes resting on walls, and in few cases, roofs and ceilings, using contact insecticides. Unfortunately, little attention is paid to where malaria vectors actually rest indoors, and how such knowledge could be used to improve IRS. This study investigated preferred resting surfaces of two major malaria vectors, Anopheles funestus and Anopheles arabiensis, inside four common house types in rural south-eastern Tanzania.

NOT Open Access | Anopheline Mosquito Species Composition, Kdr Mutation Frequency, and Parasite Infectivity Status in Northern Tanzania

January 14, 2020 - 09:42 -- NOT Open Access
Kweka EJ, Mazigo HD, Lyaruu LJ, Mausa EA, Venter N, Mahande AM, Coetzee M
Journal of Medical Entomology, tjz245

The scaling-up of malaria control interventions in northern Tanzania has resulted in a decline in malaria prevalence and vector species composition. Despite this achievement, residual malaria transmission remains a concern in the area. The main aim of this study was to investigate malaria vector species composition, parasite infectivity rates, and the presence of insecticide knockdown resistance (kdr) mutations in three sites that have experienced a significant decline in malaria in northern Tanzania. Adult mosquitoes were sampled using light traps in houses and hand-aspirators in cowsheds, whereas the standard dipping method was used for sampling mosquito larvae.

Protecting migratory farmers in rural Tanzania using eave ribbons treated with the spatial mosquito repellent, transfluthrin

December 17, 2019 - 15:53 -- Open Access
Johnson K. Swai, Arnold S. Mmbando, Fredros O. Okumu, et al.
Malaria Journal 2019 18:414, 10 December 2019

Many subsistence farmers in rural southeastern Tanzania regularly relocate to distant farms in river valleys to tend to crops for several weeks or months each year. While there, they live in makeshift semi-open structures, usually far from organized health systems and where insecticide-treated nets (ITNs) do not provide adequate protection. This study evaluated the potential of a recently developed technology, eave ribbons treated with the spatial repellent transfluthrin, for protecting migratory rice farmers in rural southeastern Tanzania against indoor-biting and outdoor-biting mosquitoes.

Review: Towards malaria elimination and its implication for vector control, disease management and livelihoods in Tanzania

January 19, 2014 - 17:16 -- Ingeborg van Schayk
Leonard E.G. Mboera, Humphrey D. Mazigo, Susan F. Rumisha, Randall A. Kramer
MWJ 2013, 4, 19


Not Open Access | Impact of Indoor Residual Spraying of Lambda-Cyhalothrin on Malaria Prevalence and Anemia in an Epidemic-Prone District of Muleba, North-Western Tanzania

May 6, 2013 - 16:19 -- NOT Open Access
Fabian M. Mashauri, Safari M. Kinung'hi, Godfrey M. Kaatano, Stephen M. Magesa, Coleman Kishamawe, Joseph R. Mwanga, Soori E. Nnko, Robert C. Malima, Chacha N. Mero, and Leonard E. G. Mboera
Am J Trop Med Hyg 2013 88:841-849

The Government of Tanzania introduced indoor residual spraying (IRS) in Muleba district in north-western Tanzania after frequent malaria epidemics.

Six new ways to control malaria mosquitoes

February 14, 2013 - 07:32 -- Bart G.J. Knols

It is well known that creative thinking is affected by environmental variables. That's why researchers engage in 'off-site' events. Take them out of their comfort zone of the lab or office and miracles may happen.

I am in Pangani, Tanzania, as I write this. Sitting amongst the palm trees overlooking the Indian ocean at Emayani Beach Lodge run by my brother. Thinking back about last week, when we had a kick-off meeting with 14 scientists and entrepreneurs in Ifakara, hosted by the Ifakara Health Institute (IHI). Although this year marks my 20th anniversary of working with IHI, quite a few of us were new to IHI, new to Tanzania, or even new to Africa...


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