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NOT Open Access | Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya

May 13, 2020 - 14:54 -- NOT Open Access
Peprah S, Ogwang MD, Mbulaiteye SM, et al.
Br J Haematol. 2020 May 12

Platelet counts are decreased in Plasmodium falciparum malaria, which is aetiologically linked with endemic Burkitt lymphoma (eBL). However, the pattern of platelet counts in eBL cases is unknown. We studied platelet counts in 582 eBL cases and 2 248 controls enrolled in a case‐control study in Uganda, Tanzania and Kenya (2010–2016). Mean platelet counts in controls or eBL cases with or without malaria‐infection in controls versus eBLcases were compared using Student’s t‐test.

Sub-national stratification of malaria risk in mainland Tanzania: a simplified assembly of survey and routine data

May 12, 2020 - 16:37 -- Open Access
Sumaiyya G. Thawer, Frank Chacky, Fabrizio Molteni, et al.
Malaria Journal 2020 19:177, 8 May 2020

Recent malaria control efforts in mainland Tanzania have led to progressive changes in the prevalence of malaria infection in children, from 18.1% (2008) to 7.3% (2017). As the landscape of malaria transmission changes, a sub-national stratification becomes crucial for optimized cost-effective implementation of interventions. This paper describes the processes, data and outputs of the approach used to produce a simplified, pragmatic malaria risk stratification of 184 councils in mainland Tanzania.

Prevalence and Correlates of Asymptomatic Malaria and Anemia on First Antenatal Care Visit among Pregnant Women in Southeast, Tanzania

May 6, 2020 - 15:54 -- Open Access
Mlugu EM, Minzi O, Kamuhabwa AAR, Aklillu E
Int J Environ Res Public Health. 2020 Apr 30;17(9), pii: E3123.

Asymptomatic malaria and anemia during pregnancy increase the risk of negative birth outcomes. This cross-sectional study investigated the prevalence and correlates of asymptomatic malaria and anemia during first antenatal care (ANC) visit among pregnant women in a rural district, Tanzania. HIV-uninfected pregnant women without symptoms of malaria (n = 819) attending their first ANC at Kibiti Health Centre were enrolled from February 2017 to February 2018.

Opinions of key stakeholders on alternative interventions for malaria control and elimination in Tanzania

April 23, 2020 - 10:29 -- Open Access
Marceline F. Finda, Nicola Christofides, Javier Lezaun, Brian Tarimo, Prosper Chaki, Ann H. Kelly, Ntuli Kapologwe, Paul Kazyoba, Basiliana Emidi and Fredros O. Okumu
Malaria Journal 2020 19:164, 23 April 2020

Malaria control in Tanzania currently relies primarily on long-lasting insecticidal nets and indoor residual spraying, alongside effective case management and behaviour change communication. This study explored opinions of key stakeholders on the national progress towards malaria elimination, the potential of currently available vector control interventions in helping achieve elimination by 2030, and the need for alternative interventions that could be used to supplement malaria elimination efforts in Tanzania.

Effect of sulfadoxine-pyrimethamine doses for prevention of malaria during pregnancy in hypoendemic area in Tanzania

April 20, 2020 - 09:51 -- Open Access
Wigilya P. Mikomangwa, Omary Minzi, Ritah Mutagonda, Vito Baraka, Eulambius M. Mlugu, Eleni Aklillu and Appolinary A. R. Kamuhabwa
Malaria Journal 2020 19:160, 19 April 2020

Malaria in pregnancy increases the risk of deleterious maternal and birth outcomes. The use of ≥ 3 doses of sulfadoxine-pyrimethamine (SP) for intermittent preventive treatment of malaria (IPTp-SP) is recommended for preventing the consequences of malaria during pregnancy. This study assessed the effect of IPTp-SP for prevention of malaria during pregnancy in low transmission settings.

Sustaining LLIN coverage with continuous distribution: the school net programme in Tanzania

April 20, 2020 - 09:04 -- Open Access
Joshua Yukich, Logan Stuck, Hannah Koenker, et al.
Malaria Journal 2020 19:158, 17 April 2020

Most malaria-endemic countries have struggled in the past decade to establish effective national-scale continuous distribution mechanisms for long-lasting insecticidal nets (LLINs). Since the implementation of the Tanzania National Voucher Scheme in 2004 and mass-distribution campaigns in 2009–2011 and 2015–2016, Tanzania has been committed to finding new and innovative ways of achieving and maintaining universal bed net coverage.

Evaluation of personal protection afforded by repellent-treated sandals against mosquito bites in south-eastern Tanzania

April 13, 2020 - 13:52 -- Open Access
Onyango P. Sangoro, Tegemeo Gavana, Marceline Finda, Winfrida Mponzi, Emmanuel Hape, Alex Limwagu, Nicodem J. Govella, Prosper Chaki and Fredros O. Okumu
Malaria Journal 2020 19:148, 8 April 2020

Outdoor and early evening mosquito biting needs to be addressed if malaria elimination is to be achieved. While indoor-targeted interventions, such as insecticide-treated nets and indoor residual spraying, remain essential, complementary approaches that tackle persisting outdoor transmission are urgently required to maximize the impact. Major malaria vectors principally bite human hosts around the feet and ankles. Consequently, this study investigated whether sandals treated with efficacious spatial repellents can protect against outdoor biting mosquitoes.

Applied mathematical modelling to inform national malaria policies, strategies and operations in Tanzania

March 9, 2020 - 13:53 -- Open Access
Manuela Runge, Fabrizio Molteni, Renata Mandike, Robert W. Snow, Christian Lengeler, Ally Mohamed and Emilie Pothin
Malaria Journal 2020 19:101, 2 March 2020

More than ever, it is crucial to make the best use of existing country data, and analytical tools for developing malaria control strategies as the heterogeneity in malaria risk within countries is increasing, and the available malaria control tools are expanding while large funding gaps exist. Global and local policymakers, as well as funders, increasingly recognize the value of mathematical modelling as a strategic tool to support decision making. This case study article describes the long-term use of modelling in close collaboration with the National Malaria Control Programme (NMCP) in Tanzania, the challenges encountered and lessons learned.

Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in Southeast of Tanzania

March 3, 2020 - 12:39 -- Open Access
Bwire GM, Ngasala B, Mikomangwa WP, Kilonzi M, Kamuhabwa AAR
Sci Rep. 2020 Feb 26;10(1):3500

In Tanzania, chloroquine was replaced by sulphadoxine- pyrimethamine (SP) as a first-line for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP lasted for only 5 years and by the end of 2006 it was replaced with the current artemisinin combination therapy. We therefore, set a study to determine the current genotypic mutations associated with Plasmodium falciparum resistance to artemisinin, partner drugs and chloroquine.

Simulating the council-specific impact of anti-malaria interventions: A tool to support malaria strategic planning in Tanzania

February 24, 2020 - 14:19 -- Open Access
Runge M, Snow RW, Pothin E, et al.
PLoS ONE 15(2): e0228469

The decision-making process for malaria control and elimination strategies has become more challenging. Interventions need to be targeted at council level to allow for changing malaria epidemiology and an increase in the number of possible interventions. Models of malaria dynamics can support this process by simulating potential impacts of multiple interventions in different settings and determining appropriate packages of interventions for meeting specific expected targets.


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