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Plasmodium cynomolgi

Safety, pharmacokinetics, and activity of high-dose ivermectin and chloroquine against the liver-stage of Plasmodium cynomolgi infection in Rhesus Macaques

July 14, 2020 - 15:56 -- Open Access
Author(s): 
Vanachayangkul P, Im-Erbsin R, Kobylinski KC, et al.
Reference: 
Antimicrob Agents Chemother. 2020 Jul 13:AAC.00741-20

Previously, ivermectin (1-10 mg/kg) was shown to inhibit liver-stage development of Plasmodium berghei in orally dosed mice. Here, ivermectin showed inhibition of the in vitro development of Plasmodium cynomolgi schizonts (IC50 = 10.42 μM) and hypnozoites (IC50 = 29.24 μM) in primary macaque hepatocytes when administered in high-dose prophylactically but not when administered in radical cure mode.

Development of an effective alternative model for in vivo hypnozoite-induced relapse infection: A Japanese macaque (Macaca fuscata) model experimentally infected with Plasmodium cynomolgi

March 3, 2020 - 15:09 -- Open Access
Author(s): 
Kawai S, Annoura T, Araki T, Shiogama Y, Soma S, Takano JI, Sato MO, Kaneko O, Yasutomi Y, Chigusa Y
Reference: 
Parasitology International, 2020 Feb 27:102096

In the present study, we demonstrate that the Japanese macaque (Macaca fuscata) can be used as an effective alternative in vivo model for investigating hypnozoite-induced relapsing infection caused by Plasmodium cynomolgi B strain, and that this model is comparable to the rhesus macaque model. Two female Japanese macaques (JM-1 and JM-2; aged 5 years; weighing about 4.0 kg) were used for the experiment.

A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation

January 14, 2020 - 12:14 -- Open Access
Author(s): 
Voorberg-van der Wel AM, Zeeman AM, Kocken CHM, et al.
Reference: 
Communications Biology, 2020 Jan 3; 3:7

Plasmodium vivax malaria is characterized by repeated episodes of blood stage infection (relapses) resulting from activation of dormant stages in the liver, so-called hypnozoites. Transition of hypnozoites into developing schizonts has never been observed. A barrier for studying this has been the lack of a system in which to monitor growth of liver stages.

Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques

September 28, 2017 - 15:35 -- Open Access
Author(s): 
Yan Tang, Chester J. Joyner, Mark P. Styczynski, et al.
Reference: 
Malaria Journal 2017 16:384, 22 September 2017

These data suggest the possibility that malarial anaemia may be driven by monocyte-associated disruption of GATA1/GATA2 function in erythroid progenitors resulting in insufficient erythropoiesis during acute infection.

NOT Open Access | Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi

September 23, 2017 - 06:21 -- NOT Open Access
Author(s): 
Varakorn Kosaisavee, Rossarin Suwanarusk, Bruce Russell, et al.
Reference: 
Blood Volume: 130, Issue: 11, Pages: 1357-1363

Two malaria parasites of Southeast Asian macaques, Plasmodium knowlesi and P cynomolgi, can infect humans experimentally.

Country: 

Anti-relapse activity of mirincamycin in the Plasmodium cynomolgi sporozoite-infected Rhesus monkey model

October 30, 2014 - 16:40 -- Open Access
Author(s): 
Susan Fracisco, Paktiya Teja-isavadharm, Montip Gettayacamin, Jonathan Berman, Qigui Li, Victor Melendez, David Saunders, Lisa Xie, Colin Ohrt
Reference: 
Malaria Journal 2014, 13:409 (17 October 2014)

cis-mirinicamycin and trans-mirinicamycin were evaluated as prophylaxis against early liver stages of Plasmodium berghei in mice and as antirelapse hypnozoiticides against Plasmodium cynomolgi in the Rhesus monkey (Macaca mulatta).

Transgenic Fluorescent Plasmodium cynomolgi Liver Stages Enable Live Imaging and Purification of Malaria Hypnozoite-Forms

February 11, 2013 - 18:10 -- Open Access
Author(s): 
Annemarie Voorberg-van der Wel, Anne-Marie Zeeman, Sandra M. van Amsterdam, Alexander van den Berg, Els J. Klooster, Shiroh Iwanaga, Chris J. Janse, Geert-Jan van Gemert, Robert Sauerwein, Niels Beenhakker, Gerrit Koopman, Alan W. Thomas, Clemens H. M. Kocken
Reference: 
PLoS ONE 8(1): e54888.
MalariaWorld

Here we report the generation of the first transgenic P. cynomolgi parasites that stably express fluorescent markers in liver stages by transfection with novel DNA-constructs containing a P. cynomolgi centromere.

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