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Assessment of molecular markers for anti-malarial drug resistance after the introduction and scale-up of malaria control interventions in western Kenya

March 10, 2015 - 13:23 -- Open Access
Monica Shah, Yusuf Omosun, Ya Shi, et al.
Malaria Journal 2015, 14:75 (14 February 2015)

 National first-line treatment changed from chloroquine (CQ) to sulphadoxine-pyrimethamine (SP) in 1998 and to artemether-lumefantrine (AL) in 2004. ITN use was scaled-up in the Asembo, Gem and Karemo areas of western Kenya in 1997, 1999 and 2006, respectively.

Not Open Access | Prevalence of mutations in the antifolates resistance-associated genes (dhfr and dhps) in Plasmodium vivax parasites from Eastern and Central Sudan

June 20, 2014 - 17:45 -- NOT Open Access
Sekineh Pirahmadi, Badawi Abdelbagi Talha, Bakri Y.M. Nour, Sedigheh Zakeri
Infection, Genetics and Evolution, Volume 26, August 2014, Pages 153-159

Therefore, the main objective of the present study was to provide data on the prevalence of molecular markers in two genes (pvdhfr and pvdhps) associated with SP resistance after nine years of AS + SP deployment among P. vivax parasites from Eastern and Central Sudan using PCR-RFLP.

Not Open Access | Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: Impact on vaccine design for placental malaria

May 13, 2014 - 18:06 -- NOT Open Access
Bita Bordbar, Nicaise Tuikue Ndam, Audrey Sabbagh, et al.
Infection, Genetics and Evolution, Volume 25, July 2014, Pages 81-92

In this study, we examined patterns of sequence variation of ID1-DBL2Xb in a large collection of P. falciparum field isolates (n = 247) from different malaria-endemic areas, including Africa (Benin, Senegal, Cameroon and Madagascar), Asia (Cambodia), Oceania (Papua New Guinea), and Latin America (Peru).

In vitro studies on the sensitivity pattern of Plasmodium falciparum to anti-malarial drugs and local herbal extracts

February 26, 2014 - 16:38 -- Open Access
Olasehinde GI, Ojurongbe O, Adeyeba AO, Fagade OE, Valecha N, Ayanda IO, Ajayi AA
Malaria Journal 2014, 13 :63 (20 February 2014)

Fifty-one percent of the isolates were resistant to chloroquine, 13% to amodiaquine and 5% to sulphadoxine/pyrimethamine. Highest resistance to chloroquine (68.9%) was recorded among isolates from Yewa zone while highest resistance to amodiaquine (30%) was observed in Ijebu zone. 

The association between price, competition, and demand factors on private sector anti-malarial stocking and sales in western Kenya: considerations for the AMFm subsidy

June 10, 2013 - 16:42 -- Open Access
Prudhomme O'Meara W, Obala A, Thirumurthy H, Khwa-Otsyula B
Malaria Journal 2013, 12:186 (5 June 2013)

Ninety-seven retail outlets in the study area were surveyed; 11% of outlets stocked subsidized AL. Size of the outlet and having a pharmacist on staff were associated with greater likelihood of stocking subsidized AL. 


Evaluation of bioluminescence-based assays of anti-malarial drug activity

February 11, 2013 - 18:01 -- Open Access
Hasenkamp S, Sidaway A, Devine O, Roye R, Horrocks P
Malaria Journal 2013, 12:58 (8 February 2013)

This study suggests that opportunities for bioluminescence-based assays lie not in the measurement of 50% inhibition concentrations, where the cheaper fluorescence assay performs excellently and is not restricted by the need to genetically modify the parasite clone under investigation

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