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celebral malaria

Not Open Access | Outcomes measures in children after acute central nervous system infections and malaria

November 19, 2019 - 15:19 -- NOT Open Access
Author(s): 
Postels, Douglas G; Soldatos, Ariane; LaRovere, Kerri L
Reference: 
Current Opinion in Pediatrics: December 2019 - Volume 31 - Issue 6 - p 756–762

Standardized documentation and coding of clinically important outcomes is needed. Further research to evaluate effective practices using acute adjunctive and rehabilitation therapies will be aided by outcome measure standardization.

Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults

May 3, 2016 - 14:49 -- Open Access
Author(s): 
Yakhya Dieye, Babacar Mbengue, Shobha Dagamajalu, Mouhamadou Mansour Fall, Mun Fai Loke, Cheikh Momar Nguer, Alassane Thiam, Jamuna Vadivelu and Alioune Dieye
Reference: 
Peer J

 Our results suggest that a poorly controlled inflammatory response determines a bad outcome in African adults suffering of cerebral malaria.

Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria

July 6, 2015 - 14:45 -- Open Access
Author(s): 
Emile B. Gordon, Geoffrey T. Hart, Susan K. Pierce, et al.
Reference: 
American Society of Microbiology

These results open a new avenue for the development of highly selective adjunctive therapies for CM by targeting pathways that regulate host and parasite metabolism.

Not Open Accesss | Cerebral malaria.

July 13, 2013 - 12:58 -- NOT Open Access
Author(s): 
Postels DG, Birbeck GL.
Reference: 
Handb Clin Neurol. 2013;114:91-102.
MalariaWorld

Thus far, adjuvant therapies have not been shown to improve mortality rates or neurological outcomes in children with CM. For those who survive CM, residual neurological abnormalities are common.

Continent: 
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Not Open Access | A rare non-synonymous c.102C>G SNP in the IFNB1 gene might be a risk factor for cerebral malaria in Indian populations

February 12, 2013 - 17:36 -- NOT Open Access
Author(s): 
Aditya Nath Jha, Vipin Kumar Singh, Rajender Singh, Sudhanshu S. Pati, Pradeep K. Patra, Lalji Singh, Kumarasamy Thangaraj
Reference: 
Infection, Genetics and Evolution, Volume 14, March 2013, Pages 369-374
MalariaWorld

Our findings suggest that the IFNB1 variant, p.Ser34Arg, might be a risk factor for cerebral malaria in Indian populations.

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Endoplasmic Reticulum Stress and Neurodegeneration in Experimental Cerebral Malaria

February 5, 2013 - 16:40 -- Open Access
Author(s): 
Anand S.S. • Babu P.P.
Reference: 
Neurosignals
MalariaWorld

 In the present study, we report the presence of endoplasmic reticulum (ER) stress markers and activation of the unfolded protein response (UPR) in the brain during the pathogenesis of ECM. Specific findings included activation of PKR-like ERkinase, inositol-requiring enzyme 1 and cleavage of activating transcription factor (ATF) 6 indicating the activation of all three major arms of the UPR.

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