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chloroquine resistance

Plasmodium knowlesi as a model system for characterising Plasmodium vivax drug resistance candidate genes

June 11, 2019 - 15:08 -- Open Access
Lisa H. Verzier, Rachael Coyle, Shivani Singh, Theo Sanderson, Julian C. Rayner
PLoS Negl Trop Dis 13(6): e0007470

Plasmodium vivax causes the majority of malaria outside Africa, but is poorly understood at a cellular level partly due to technical difficulties in maintaining it in in vitro culture conditions.

Chloroquine resistance is associated to multi-copy pvcrt-o gene in Plasmodium vivax malaria in the Brazilian Amazon

July 17, 2018 - 15:59 -- Open Access
Siuhelem Rocha Silva, Anne Cristine Gomes Almeida, Gisely Cardoso de Melo, et al.
Malaria Journal 2018 17:267, 16 July 2018

This was the first study with 42-day clinical follow-up to evaluate the variation of the number of copies and polymorphisms in the promoter region of the pvcrt-o and pvmdr1 genes in relation to treatment outcomes.

Medical Condition: 

Therapeutic assessment of chloroquine–primaquine combined regimen in adult cohort of Plasmodium vivax malaria from a tertiary care hospital in southwestern India

August 12, 2015 - 13:22 -- Open Access
Kumar Rishikesh, Asha Kamath, Manjunatha H Hande, Sudha Vidyasagar, Raviraja V Acharya, Vasudeva Acharya, Jayaprakash Belle, Ananthakrishna B Shastry, Kavitha Saravu
Malaria Journal 2015, 14:310 (11 August 2015)

CQ–PQ combined regimen remains outstandingly effective for uncomplicated P. vivax malaria and should be retained as treatment of choice in the study region.


Prevalence of Plasmodium falciparum anti-malarial resistance-associated polymorphisms in pfcrt, pfmdr1 and pfnhe1 in Muheza, Tanzania, prior to introduction of artemisinin combination therapy

March 31, 2015 - 17:31 -- Open Access
Nahla B Gadalla, Gloria Tavera, Jianbing Mu, Edward R Kabyemela, Michael Fried, Patrick E Duffy, Juliana M Sá, Thomas E Wellems
Malaria Journal 2015, 14:129 (25 March 2015)

The pfcrt-CVIET chloroquine resistance haplotype dominated in the collection of P. falciparum samples from Muheza.


NOT Open Access | In vitro and in vivo antiplasmodial activity of the root extracts of Brucea mollis Wall. ex Kurz

February 1, 2013 - 09:11 -- NOT Open Access
Anil Prakash, S. K. Sharma, P. K. Mohapatra, K. Bhattacharjee, K. Gogoi, P. Gogoi, J. Mahanta & D. R. Bhattacharyya
Parasitology Research, February 2013, Volume 112, Issue 2, pp 637-642

Malaria control is compromised worldwide by continuously evolving drug-resistant strains of the parasite demanding exploration of natural resources for developing newer antimalarials.

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