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chloroquine resistance

Plasmodium knowlesi as a model system for characterising Plasmodium vivax drug resistance candidate genes

June 11, 2019 - 15:08 -- Open Access
Author(s): 
Lisa H. Verzier, Rachael Coyle, Shivani Singh, Theo Sanderson, Julian C. Rayner
Reference: 
PLoS Negl Trop Dis 13(6): e0007470

Plasmodium vivax causes the majority of malaria outside Africa, but is poorly understood at a cellular level partly due to technical difficulties in maintaining it in in vitro culture conditions.

Chloroquine resistance is associated to multi-copy pvcrt-o gene in Plasmodium vivax malaria in the Brazilian Amazon

July 17, 2018 - 15:59 -- Open Access
Author(s): 
Siuhelem Rocha Silva, Anne Cristine Gomes Almeida, Gisely Cardoso de Melo, et al.
Reference: 
Malaria Journal 2018 17:267, 16 July 2018

This was the first study with 42-day clinical follow-up to evaluate the variation of the number of copies and polymorphisms in the promoter region of the pvcrt-o and pvmdr1 genes in relation to treatment outcomes.

Medical Condition: 

Therapeutic assessment of chloroquine–primaquine combined regimen in adult cohort of Plasmodium vivax malaria from a tertiary care hospital in southwestern India

August 12, 2015 - 13:22 -- Open Access
Author(s): 
Kumar Rishikesh, Asha Kamath, Manjunatha H Hande, Sudha Vidyasagar, Raviraja V Acharya, Vasudeva Acharya, Jayaprakash Belle, Ananthakrishna B Shastry, Kavitha Saravu
Reference: 
Malaria Journal 2015, 14:310 (11 August 2015)

CQ–PQ combined regimen remains outstandingly effective for uncomplicated P. vivax malaria and should be retained as treatment of choice in the study region.

Country: 

Prevalence of Plasmodium falciparum anti-malarial resistance-associated polymorphisms in pfcrt, pfmdr1 and pfnhe1 in Muheza, Tanzania, prior to introduction of artemisinin combination therapy

March 31, 2015 - 17:31 -- Open Access
Author(s): 
Nahla B Gadalla, Gloria Tavera, Jianbing Mu, Edward R Kabyemela, Michael Fried, Patrick E Duffy, Juliana M Sá, Thomas E Wellems
Reference: 
Malaria Journal 2015, 14:129 (25 March 2015)

The pfcrt-CVIET chloroquine resistance haplotype dominated in the collection of P. falciparum samples from Muheza.

Country: 

NOT Open Access | In vitro and in vivo antiplasmodial activity of the root extracts of Brucea mollis Wall. ex Kurz

February 1, 2013 - 09:11 -- NOT Open Access
Author(s): 
Anil Prakash, S. K. Sharma, P. K. Mohapatra, K. Bhattacharjee, K. Gogoi, P. Gogoi, J. Mahanta & D. R. Bhattacharyya
Reference: 
Parasitology Research, February 2013, Volume 112, Issue 2, pp 637-642
MalariaWorld

Malaria control is compromised worldwide by continuously evolving drug-resistant strains of the parasite demanding exploration of natural resources for developing newer antimalarials.

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