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plasmodium falciprum

Malaria Screener: a smartphone application for automated malaria screening

November 12, 2020 - 15:50 -- Open Access
Yu H, Yang F, Rajaraman S, Ersoy I, Moallem G, Poostchi M, Palaniappan K, Antani S, Maude RJ, Jaeger S
BMC Infect Dis. 2020 Nov 11;20(1):825

Light microscopy is often used for malaria diagnosis in the field. However, it is time-consuming and quality of the results depends heavily on the skill of microscopists. Automating malaria light microscopy is a promising solution, but it still remains a challenge and an active area of research. Current tools are often expensive and involve sophisticated hardware components, which makes it hard to deploy them in resource-limited areas.

NOT Open Access | Antiplasmodial Alkaloids from the Australian Bryozoan Amathia lamourouxi

October 28, 2020 - 09:55 -- NOT Open Access
Kleks G, Holland DC, Kennedy EK, Avery VM, Carroll AR
J Nat Prod. 2020 Oct 26

An extract from the bryozoan Amathia lamourouxi with antiplasmodial activity was identified through high-throughput screening of an Australian marine invertebrate extract library against Plasmodium falciparum. Chemical investigation of A. lamourouxi resulted in the isolation of six new brominated alkaloids, convolutamines K and L (1 and 2), volutamides F-H (3-5), and 2,5-dibromo-1-methyl-1H-indole-3-carbaldehyde (6).

Updates on malaria epidemiology and profile in Cabo Verde from 2010 to 2019: the goal of elimination

October 27, 2020 - 15:53 -- Open Access
Adilson José DePina, Gillian Stresman, Helga Sofia Baptista Barros, António Lima Moreira, Abdoulaye Kane Dia, Ullardina Domingos Furtado, Ousmane Faye, Ibrahima Seck and El Hadji Amadou Niang
Malaria Journal 2020 19:380, 23 October 2020

Located in West Africa, Cabo Verde is an archipelago consisting of nine inhabited islands. Malaria has been endemic since the settlement of the islands during the sixteenth century and is poised to achieve malaria elimination in January 2021. The aim of this research is to characterize the trends in malaria cases from 2010 to 2019 in Cabo Verde as the country transitions from endemic transmission to elimination and prevention of reintroduction phases.

NOT Open ACcess | γẟ T cells in malaria: a double edged sword

July 27, 2020 - 15:04 -- NOT Open Access
Pamplona A, Silva-Santos B
FEBS J. 2020 Jul 24

Malaria remains a devastating global health problem, resulting in many annual deaths due to the complications of severe malaria. However, in endemic regions, individuals can acquire "clinical immunity" to malaria, characterized by a decrease in severe malaria episodes and an increase of asymptomatic Plasmodium falciparum infections. Recently, it has been reported that tolerance to "clinical malaria" and reduced disease severity correlates with a decrease in the numbers of circulating Vγ9Vδ2 T cells, the major subset of γδ T cells in the human peripheral blood.

Not Open Access] Structure-based binding between protein farnesyl transferase and PRL-PTP of malaria parasite: an interaction study of prenylation process in Plasmodium

May 3, 2016 - 15:05 -- NOT Open Access
Rani Soni, Drista Sharma, Sachin Patel, Bhaskar Sharma & Tarun Kumar Bhatt
Journal of Biomolecular Structure and Dynamics

Therefore, in this study, we have modeled both PfPFT and its substrate protein tyrosine phosphatase (PfPRL-PTP) followed by interaction studies using protein–protein docking and molecular dynamics simulation. 

Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults

May 3, 2016 - 14:49 -- Open Access
Yakhya Dieye, Babacar Mbengue, Shobha Dagamajalu, Mouhamadou Mansour Fall, Mun Fai Loke, Cheikh Momar Nguer, Alassane Thiam, Jamuna Vadivelu and Alioune Dieye
Peer J

 Our results suggest that a poorly controlled inflammatory response determines a bad outcome in African adults suffering of cerebral malaria.

A combined within-host and between-hosts modelling framework for the evolution of resistance to antimalarial drugs.

April 19, 2016 - 14:49 -- Open Access
Legros M, Bonhoeffer S
J R Soc Interface. 2016 Apr;13(117)

We show that the spread of resistance is generally less likely in areas of intense transmission, and therefore of increased competition between strains, an effect exacerbated when costs of resistance are higher. 

Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola

December 22, 2015 - 17:00 -- Open Access
Kinanga Kiaco, Joana Teixeira, Marta Machado, Virgílio do Rosário, Dinora Lopes
Malaria Journal 2015, 14:504 (16 December 2015)

These results showed changes in parasite profile susceptibility to AL in comparison to the baseline data from 2002 to 2004 and on the genotyping characteristics;

Chronic Exposure to Plasmodium falciparum Is Associated with Phenotypic Evidence of B and T Cell Exhaustion

January 22, 2013 - 09:00 -- Open Access
Joseph Illingworth, Noah S. Butler, Sophie Roetynck, Jedida Mwacharo, Susan K. Pierce, Philip Bejon, Peter D. Crompton, Kevin Marsh, and Francis M. Ndungu
The Journal of Immunology February 1, 2013 vol. 190 no. 3 1038-1047

Naturally acquired immunity to malaria develops slowly, requiring several years of repeated exposure to be effective.

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