The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 11110 malaria professionals are enjoying the free benefits of MalariaWorld today

anti-malarials

Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

October 13, 2020 - 12:41 -- Open Access
Author(s): 
Vijay Potluri, Radha K. Shandil, R. Gavara, Ganesh Sambasivam, Brice Campo, Sergio Wittlin and Shridhar Narayanan
Reference: 
Malaria Journal 2020 19:365, 12 October 2020

Emergence of anti-malarial drug resistance and perpetual increase in malaria incidence necessitates the development of novel anti-malarials. Histone deacetylases (HDAC) has been shown to be a promising target for malaria, despite this, there are no HDAC inhibitors in clinical trials for malaria treatment. This can be attributed to the poor pharmacokinetics, bioavailability and selectivity of the HDAC inhibitors.

Correlation between anti-malarial and anti-haemozoin activities of anti-malarial compounds

August 24, 2020 - 14:09 -- Open Access
Author(s): 
Dao Ngoc Hien Tam, Gehad Mohamed Tawfik, Nguyen Tien Huy, et al.
Reference: 
Malaria Journal 2020 19:298, 21 August 2020

Despite noticeable improvement in anti-malarial treatment, rapid growth of resistant malaria strains points out the need for continuous development of novel anti-malarials to fight the disastrous infection. Haemozoin is considered as a novel inhibitory pathway for new anti-malarial drugs, therefore, this study aimed to systematically review all articles investigating the correlation between anti-malarial and anti-haemozoin activities of anti-malarial compounds.

Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds

June 9, 2020 - 16:11 -- Open Access
Author(s): 
Awet Alem Teklemichael, Shusaku Mizukami, Kenji Hirayama, et al.
Reference: 
Malaria Journal 2020 19:204, 8 June 2020

Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine (‘Kampo’) were examined for their potential anti-malarial activities.

Systematic literature review and meta-analysis of the efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: methodological challenges

December 13, 2017 - 15:52 -- Open Access
Author(s): 
Makoto Saito, Mary Ellen Gilder, François Nosten, Rose McGready and Philippe J. Guérin
Reference: 
Malaria Journal 2017 16:488, 13 December 2017

Efficacy studies in pregnancy are not only limited in number but use varied methodological assessments. In five RCTs with comparable methodology, ABT resulted in higher efficacy than QBT in the second and third trimester of pregnancy.

Medical Treatment: 

Evidence on anti-malarial and diagnostic markets in Cambodia to guide malaria elimination strategies and policies

May 3, 2017 - 08:54 -- Open Access
Author(s): 
Sochea Phok and Dysoley Lek
Reference: 
Malaria Journal 2017 16:171, 25 April 2017

The results point to high availability and distribution of first-line ACT and widespread availability of malaria diagnosis, especially in the public sector.

Country: 

Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

October 14, 2015 - 08:49 -- Open Access
Author(s): 
Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
Reference: 
Malaria Journal 2015, 14:403 (12 October 2015)

The HLC assay provides data on inhibiting properties of compounds.

Medical Treatment: 

The counterfeit anti-malarial is a crime against humanity: a systematic review of the scientific evidence

June 10, 2014 - 15:22 -- Open Access
Author(s): 
Karunamoorthi K
Reference: 
Malaria Journal 2014, 13 :209 (2 June 2014)

Combating counterfeit anti-malarials is a complex task due to limited resources and poor techniques for the detection and identification of fake anti-malarials.

Adverse drug events resulting from use of drugs with sulphonamide-containing anti-malarials and artemisinin-based ingredients: findings on incidence and household costs from three districts with routine demographic surveillance systems in rural Tanzania

July 16, 2013 - 15:51 -- Open Access
Author(s): 
Njau JD, Kabanywanyi AM, Goodman CA, MacArthur JR, Kapella BK, Gimnig JE, Kahigwa E, Bloland PB, Abdulla SM, Kachur SP
Reference: 
Malaria Journal 2013, 12:236 (11 July 2013)
MalariaWorld

This study aimed to document ADR incidence and associated household costs in three high malaria transmission districts in rural Tanzania covered by demographic surveillance systems.

Country: 

NOT Open Access | Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold

January 22, 2013 - 07:52 -- NOT Open Access
Author(s): 
Claire-Lise Ciana, Romain Siegrist, Christoph Boss, et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 23, Issue 3, 1 February 2013, Pages 658–662
MalariaWorld

A novel series of anti-malarials, based on a hydroxy-ethyl-amine scaffold, initially identified as peptidomimetic protease inhibitors is described.

Subscribe to RSS - anti-malarials