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malaria vectors

Mapping trends in insecticide resistance phenotypes in African malaria vectors

June 29, 2020 - 16:10 -- Open Access
Hancock PA, Hendriks CJM, Tangena JA, Gibson H, Hemingway J, Coleman M, Gething PW, Cameron E, Bhatt S, Moyes CL
PLoS Biol. 2020 Jun 25; 18(6):e3000633

Mitigating the threat of insecticide resistance in African malaria vector populations requires comprehensive information about where resistance occurs, to what degree, and how this has changed over time. Estimating these trends is complicated by the sparse, heterogeneous distribution of observations of resistance phenotypes in field populations.

Methods and indicators for measuring patterns of human exposure to malaria vectors

June 17, 2020 - 13:04 -- Open Access
April Monroe, Sarah Moore, Fredros Okumu, Samson Kiware, Neil F. Lobo, Hannah Koenker, Ellie Sherrard-Smith, John Gimnig and Gerry F. Killeen
Malaria Journal 2020 19:207, 16 June 2020

Effective targeting and evaluation of interventions that protect against adult malaria vectors requires an understanding of how gaps in personal protection arise. An improved understanding of human and mosquito behaviour, and how they overlap in time and space, is critical to estimating the impact of insecticide-treated nets (ITNs) and determining when and where supplemental personal protection tools are needed. Methods for weighting estimates of human exposure to biting Anopheles mosquitoes according to where people spend their time were first developed over half a century ago. However, crude indoor and outdoor biting rates are still commonly interpreted as indicative of human-vector contact patterns without any adjustment for human behaviour or the personal protection effects of ITNs.

NOT Open Access | First Observation of Experimental Plasmodium vivax Infection of Three Malaria Vectors from the Brazilian Amazon

April 10, 2020 - 16:57 -- NOT Open Access
Araújo MDS, Andrade AO, Dos Santos NAC, Castro RB, Pereira DB, Rodrigues MMS, Costa GDS, Pereira Júnior AM, Carvalho LPC, Medeiros JF, Pereira-da-Silva LH
Vector Borne Zoonotic Dis. 2020 Apr 7

Although malaria is endemic to the Amazon region, little is known about the susceptibility of potential parasite vectors in Brazil. Assessing the vector susceptibility of Anopheles mosquitoes will increase our understanding of parasite–vector interactions and aid the design of vector control strategies.

A zooprophylaxis strategy using l-lactic acid (Abate) to divert host-seeking malaria vectors from human host to treated non-host animals

February 3, 2020 - 17:21 -- Open Access
Elison E. Kemibala, Agenor Mafra-Neto, Teun Dekker, Jesse Saroli, Rodrigo Silva, Anitha Philbert, Kija Nghabi and Leonard E. G. Mboera
Malaria Journal 2020 19:52, 30 January 2020

Zooprophylaxis is a technique in which blood-seeking vectors are diverted to non-host animals in order to lower blood-feeding rates on human hosts. The success of this technique depends on the host preference of the vector being targeted. The objective of this study was to evaluate the effect of l-lactic acid (Abate) to divert malaria mosquito, Anopheles gambiae from feeding on human host.

Preferred resting surfaces of dominant malaria vectors inside different house types in rural south-eastern Tanzania

January 20, 2020 - 15:37 -- Open Access
Betwel J. Msugupakulya, Emmanuel W. Kaindoa, Halfan S. Ngowo, Japhet M. Kihonda, Najat F. Kahamba, Dickson S. Msaky, Damaris Matoke-Muhia, Patrick K. Tungu and Fredros O. Okumu
Malaria Journal 2020 19:22, 15 January 2020

Malaria control in Africa relies extensively on indoor residual spraying (IRS) and insecticide-treated nets (ITNs). IRS typically targets mosquitoes resting on walls, and in few cases, roofs and ceilings, using contact insecticides. Unfortunately, little attention is paid to where malaria vectors actually rest indoors, and how such knowledge could be used to improve IRS. This study investigated preferred resting surfaces of two major malaria vectors, Anopheles funestus and Anopheles arabiensis, inside four common house types in rural south-eastern Tanzania.

Evaluation of long-lasting indoor residual spraying of deltamethrin 62.5 SC-PE against malaria vectors in India

January 15, 2020 - 14:43 -- Open Access
Sudhansu Sekhar Sahu, Sonia Thankachy, Smrutidhara Dash, Krishnamoorthy Nallan, Subramanian Swaminathan, Gunasekaran Kasinathan and Jambulingam Purushothaman
Malaria Journal 2020 19:19, 14 January 2020

Deltamethrin 62.5 polymer-enhanced suspension concentrate (SC-PE) is one of the World Health Organization-approved insecticides for indoor residual spraying and was recommended to evaluate its residual activity for determination of appropriate spray cycles in different eco-epidemiologic settings. In the current study, efficacy of deltamethrin 62.5 SC-PE was evaluated against vectors of malaria and its impact on malaria incidence in a Plasmodium falciparum hyper-endemic area in Koraput district, Odisha State, India.

Highly specific PCR-RFLP assays for karyotyping the widespread 2Rb inversion in malaria vectors of the Anopheles gambiae complex

January 14, 2020 - 10:08 -- Open Access
Montanez-Gonzalez R, Pichler V, Calzetta M, Love RR, Vallera A, Schaecher L, Caputo B, Pombi M, Petrarca V, Della Torre A, Besansky NJ
Parasites & Vectors, Volume 13, 16 (2020)

Chromosomal inversion polymorphisms play a role in adaptation to heterogeneous environments. Inversion polymorphisms are implicated in the very high ecological flexibility of the three main malaria vector species of the Afrotropical Anopheles gambiae complex, facilitating the exploitation of anthropogenic environmental modifications and promoting a strong association with humans. In addition to extending the species’ spatial and temporal distribution, inversions are associated with epidemiologically relevant mosquito behavior and physiology, underscoring their medical importance. We here present novel PCR-RFLP based assays strongly predictive of genotype for the cosmopolitan 2Rb inversion in An. coluzzii and An. gambiae, a development which overcomes the numerous constraints inherent to traditional cytological karyotyping.

Biology and bionomics of malaria vectors in India: existing information and what more needs to be known for strategizing elimination of malaria

December 10, 2019 - 08:14 -- Open Access
Sarala K. Subbarao, Nutan Nanda, Manju Rahi and Kamaraju Raghavendra
Malaria Journal 2019 18:396, 3 December 2019

India has committed to eliminate malaria by 2030. The national framework for malaria elimination released by the Government of India plans to achieve this goal through strategic planning in a phased manner. Since vector control is a major component of disease management and vector elimination, it requires a thorough understanding of the biology and bionomics of malaria vectors exhibiting definite distribution patterns in diverse ecosystems in the country.

Evaluation of mosquito electrocuting traps as a safe alternative to the human landing catch for measuring human exposure to malaria vectors in Burkina Faso

December 9, 2019 - 15:55 -- Open Access
Antoine Sanou, W. Moussa Guelbéogo, Luca Nelli, K. Hyacinth Toé, Soumanaba Zongo, Pierre Ouédraogo, Fatoumata Cissé, Nosrat Mirzai, Jason Matthiopoulos, N’falé Sagnon and Heather M. Ferguson
Malaria Journal 2019 18:386, 2 December 2019

Measuring human exposure to mosquito bites is a crucial component of vector-borne disease surveillance. For malaria vectors, the human landing catch (HLC) remains the gold standard for direct estimation of exposure. This method, however, is controversial since participants risk exposure to potentially infected mosquito bites. Recently an exposure-free mosquito electrocuting trap (MET) was developed to provide a safer alternative to the HLC. Early prototypes of the MET performed well in Tanzania but have yet to be tested in West Africa, where malaria vector species composition, ecology and behaviour are different. The performance of the MET relative to HLC for characterizing mosquito vector population dynamics and biting behaviour in Burkina Faso was evaluated.

Absence of knockdown mutations in pyrethroid and DDT resistant populations of the main malaria vectors in Colombia

December 9, 2019 - 15:35 -- Open Access
Lorena I. Orjuela, Diego A. Álvarez-Diaz, Juliana A. Morales, Nelson Grisales, Martha L. Ahumada, Juan Venegas H, Martha L. Quiñones and María F. Yasnot
Malaria Journal 2019 18:384, 2 December 2019

Knockdown resistance (kdr) is a well-characterized target-site insecticide resistance mechanism that is associated with DDT and pyrethroid resistance. Even though insecticide resistance to pyrethroids and DDT have been reported in Anopheles albimanus, Anopheles benarrochi sensu lato (s.l.), Anopheles darlingi, Anopheles nuneztovari s.l., and Anopheles pseudopunctipennis s.l. malaria vectors in Latin America, there is a knowledge gap on the role that kdr resistance mechanisms play in this resistance. The aim of this study was to establish the role that kdr mechanisms play in pyrethroid and DDT resistance in the main malaria vectors in Colombia, in addition to previously reported metabolic resistance mechanisms, such as mixed function oxidases (MFO) and nonspecific esterases (NSE) enzyme families.


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