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Primaquine

Simultaneous quantitation of chloroquine and primaquine by UPLC-DAD and comparison with a HPLC-DAD method

February 24, 2015 - 16:13 -- Open Access
Author(s): 
Tiago A Miranda, Pedro HR Silva, Gerson A Pianetti, Isabela C César
Reference: 
Malaria Journal 2015, 14:29 (28 January 2015)

Thus, the aim of this study was to develop and validate a novel UPLC-DAD method for simultaneously quantifying chloroquine and primaquine in tablet formulations.

Primaquine: the risks and the benefits

November 10, 2014 - 17:56 -- Open Access
Author(s): 
Elizabeth A Ashley, Judith Recht, Nicholas J White
Reference: 
Malaria Journal 2014, 13:418 (3 November 2014)

All but one death followed multiple dosing to prevent vivax malaria relapse. Review of dose-response relationships and clinical trials of primaquine in G6PD deficiency suggests that the currently recommended WHO single low dose (0.25 mg base/kg) to block falciparum malaria transmission confers a very low risk of haemolytic toxicity.

Not Open Access | Reduced Dose of Primaquine Effective in Blocking Malaria Transmission

January 17, 2014 - 19:00 -- NOT Open Access
Author(s): 
M. J. Friedrich
Reference: 
JAMA. 2014;311(3):235

A single lower dose of primaquine is as effective as the higher standard dose that is recommended for preventing transmission of the malarial parasite Plasmodium falciparum from humans to mosquitoes, report researchers from the London School of Hygiene and Tropical Medicine, in the United Kingdom

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

June 26, 2013 - 09:42 -- Open Access
Author(s): 
Pybus BS, Marcsisin SR, Jin X, Deye G, Sousa JC, Li Q, Caridha D, Zeng Q, Reichard GA, Ockenhouse C, Bennett J, Walker LA, Ohrt C, Melendez V
Reference: 
Malaria Journal 2013, 12:212 (20 June 2013)
MalariaWorld

These results unambiguously demonstrate that metabolism of PQ by CYP 2D6 is essential for anti-malarial causal prophylaxis efficacy.

Tools for mass screening of G6PD deficiency: validation of the WST8/1-methoxy-PMS enzymatic assay in Uganda

June 24, 2013 - 15:27 -- Open Access
Author(s): 
De Niz M, Eziefula AC, Othieno L, Mbabazi E, Nabukeera D, Ssemmondo E, Gonahasa S, Tumwebaze P, DiLiberto D, Maiteki-Sebuguzi C, Staedke SG, Drakeley C
Reference: 
Malaria Journal 2013, 12:210 (19 June 2013)
MalariaWorld

The WST8/1-methoxy PMS assay was found to have 72% sensitivity and 98% specificity when compared to the commercial enzymatic assay and the AUC was 0.904, suggesting good agreement.

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Not Open Access | Blood Stage of Plasmodium vivax in Central China Is Still Susceptible to Chloroquine Plus Primaquine Combination Therapy.

May 17, 2013 - 18:08 -- NOT Open Access
Author(s): 
Zhu G, Lu F, Cao J, Zhou H, Liu Y, Han ET, Gao Q
Reference: 
Am J Trop Med Hyg. 2013 May 13.
MalariaWorld

In central China, Plasmodium vivax accounts for all of the native reported cases of malaria. Chloroquine (CQ) plus primaquine (PQ) have been used for more than 60 years as the frontline drugs, but the risk of treatment failure remains unknown. 

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Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report

April 2, 2013 - 13:00 -- Open Access
Author(s): 
von Seidlein L, Auburn S, Espino F, Shanks D, Cheng Q, McCarthy J, Baird K, Moyes C, Howes R, Ménard D, Bancone G, Winasti-Satyahraha A, Vestergaard L, Green J, Domingo G, Yeung S, Price R
Reference: 
Malaria Journal 2013, 12:112 (27 March 2013)
MalariaWorld

 The discussions and conclusions of a workshop conducted in Incheon, Korea in May 2012 to review key knowledge gaps in G6PD deficiency are reported here.

The Potential Elimination of Plasmodium vivax Malaria by Relapse Treatment: Insights from a Transmission Model and Surveillance Data from NW India

January 15, 2013 - 15:01 -- Open Access
Author(s): 
Manojit Roy, Menno J. Bouma, Edward L. Ionides, Ramesh C. Dhiman, Mercedes Pascual
Reference: 
PLoS Negl Trop Dis 7(1): e1979.
MalariaWorld

To quantify relapse parameters and assess the population-wide consequences of anti-relapse treatment, we formulated a transmission model for P. vivax suitable for parameter inference with a recently developed statistical method based on routine surveillance data.

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