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Primaquine

Tools for mass screening of G6PD deficiency: validation of the WST8/1-methoxy-PMS enzymatic assay in Uganda

June 24, 2013 - 15:27 -- Open Access
Author(s): 
De Niz M, Eziefula AC, Othieno L, Mbabazi E, Nabukeera D, Ssemmondo E, Gonahasa S, Tumwebaze P, DiLiberto D, Maiteki-Sebuguzi C, Staedke SG, Drakeley C
Reference: 
Malaria Journal 2013, 12:210 (19 June 2013)
MalariaWorld

The WST8/1-methoxy PMS assay was found to have 72% sensitivity and 98% specificity when compared to the commercial enzymatic assay and the AUC was 0.904, suggesting good agreement.

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Not Open Access | Blood Stage of Plasmodium vivax in Central China Is Still Susceptible to Chloroquine Plus Primaquine Combination Therapy.

May 17, 2013 - 18:08 -- NOT Open Access
Author(s): 
Zhu G, Lu F, Cao J, Zhou H, Liu Y, Han ET, Gao Q
Reference: 
Am J Trop Med Hyg. 2013 May 13.
MalariaWorld

In central China, Plasmodium vivax accounts for all of the native reported cases of malaria. Chloroquine (CQ) plus primaquine (PQ) have been used for more than 60 years as the frontline drugs, but the risk of treatment failure remains unknown. 

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Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report

April 2, 2013 - 13:00 -- Open Access
Author(s): 
von Seidlein L, Auburn S, Espino F, Shanks D, Cheng Q, McCarthy J, Baird K, Moyes C, Howes R, Ménard D, Bancone G, Winasti-Satyahraha A, Vestergaard L, Green J, Domingo G, Yeung S, Price R
Reference: 
Malaria Journal 2013, 12:112 (27 March 2013)
MalariaWorld

 The discussions and conclusions of a workshop conducted in Incheon, Korea in May 2012 to review key knowledge gaps in G6PD deficiency are reported here.

The Potential Elimination of Plasmodium vivax Malaria by Relapse Treatment: Insights from a Transmission Model and Surveillance Data from NW India

January 15, 2013 - 15:01 -- Open Access
Author(s): 
Manojit Roy, Menno J. Bouma, Edward L. Ionides, Ramesh C. Dhiman, Mercedes Pascual
Reference: 
PLoS Negl Trop Dis 7(1): e1979.
MalariaWorld

To quantify relapse parameters and assess the population-wide consequences of anti-relapse treatment, we formulated a transmission model for P. vivax suitable for parameter inference with a recently developed statistical method based on routine surveillance data.

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