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Primaquine

Barriers to routine G6PD testing prior to treatment with primaquine

August 14, 2017 - 15:34 -- Open Access
Author(s): 
Benedikt Ley, Kamala Thriemer, Jessica Jaswal, Eugenie Poirot, Mohammad Shafiul Alam, Ching Swe Phru, Wasif Ali Khan, Lek Dysoley, Gao Qi, Chong Chee Kheong, Ummi Kalthom Shamsudin, Ingrid Chen, Jimee Hwang, Roly Gosling and Ric N. Price
Reference: 
Malaria Journal 2017 16:329, 10 August 2017

Greater efforts are needed to increase awareness of the benefits of the radical cure of Plasmodium vivax and this should be supported by economic analyses exploring the cost effectiveness of routine G6PD testing.

Sharp increase of imported Plasmodium vivax malaria seen in migrants from Eritrea in Hamburg, Germany

June 21, 2016 - 14:29 -- Open Access
Author(s): 
Louise Roggelin, Dennis Tappe, Bernd Noack, Marylyn M. Addo, Egbert Tannich and Camilla Rothe
Reference: 
Malaria Journal 2016 15:325, 17 June 2016

Countries hosting Eritrean refugees need to be aware of vivax malaria occurring in this group and the risk of autochthonous cases due to local transmission by indigenous, vector competent Anopheles species.

Rethinking Dosing Regimen Selection of Piperaquine for Malaria Chemoprevention: A Simulation Study

May 24, 2016 - 15:30 -- Open Access
Author(s): 
Nancy C. Sambol, Jordan W. Tappero, Emmanuel Arinaitwe, Sunil Parikh
Reference: 
PLoS ONE 11(5): e0154623

Once weekly chemoprevention of DP predicts favourable exposures with respect to both trough and peak concentrations.

Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency

August 26, 2015 - 16:21 -- Open Access
Author(s): 
Sim Kheng, Sinoun Muth, Eva Christophe, et al.
Reference: 
BMC Medicine 2015, 13:203

This study was conducted to assess the tolerability of a primaquine regimen in Cambodian severely deficient G6PD variants to ascertain whether a weekly primaquine could be given without testing for G6PDd.

Not Open Access | A Simple Real-Time PCR and Amplicon Sequencing Method for Identification of Plasmodium Species in Human Whole Blood

May 20, 2015 - 15:12 -- NOT Open Access
Author(s): 
Lefterova MI, Budvytiene I, Sandlund J, Färnert A, Banaei N
Reference: 
J Clin Microbiol. 2015 May 13. pii: JCM.00542-15.

Here we describe a SYBR Green-based real-time PCR assay for Plasmodium species identification from whole blood, which uses a panel of reactions to detect species-specific non-18S rRNA gene targets.

Simultaneous quantitation of chloroquine and primaquine by UPLC-DAD and comparison with a HPLC-DAD method

February 24, 2015 - 16:13 -- Open Access
Author(s): 
Tiago A Miranda, Pedro HR Silva, Gerson A Pianetti, Isabela C César
Reference: 
Malaria Journal 2015, 14:29 (28 January 2015)

Thus, the aim of this study was to develop and validate a novel UPLC-DAD method for simultaneously quantifying chloroquine and primaquine in tablet formulations.

Primaquine: the risks and the benefits

November 10, 2014 - 17:56 -- Open Access
Author(s): 
Elizabeth A Ashley, Judith Recht, Nicholas J White
Reference: 
Malaria Journal 2014, 13:418 (3 November 2014)

All but one death followed multiple dosing to prevent vivax malaria relapse. Review of dose-response relationships and clinical trials of primaquine in G6PD deficiency suggests that the currently recommended WHO single low dose (0.25 mg base/kg) to block falciparum malaria transmission confers a very low risk of haemolytic toxicity.

Not Open Access | Reduced Dose of Primaquine Effective in Blocking Malaria Transmission

January 17, 2014 - 19:00 -- NOT Open Access
Author(s): 
M. J. Friedrich
Reference: 
JAMA. 2014;311(3):235

A single lower dose of primaquine is as effective as the higher standard dose that is recommended for preventing transmission of the malarial parasite Plasmodium falciparum from humans to mosquitoes, report researchers from the London School of Hygiene and Tropical Medicine, in the United Kingdom

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

June 26, 2013 - 09:42 -- Open Access
Author(s): 
Pybus BS, Marcsisin SR, Jin X, Deye G, Sousa JC, Li Q, Caridha D, Zeng Q, Reichard GA, Ockenhouse C, Bennett J, Walker LA, Ohrt C, Melendez V
Reference: 
Malaria Journal 2013, 12:212 (20 June 2013)
MalariaWorld

These results unambiguously demonstrate that metabolism of PQ by CYP 2D6 is essential for anti-malarial causal prophylaxis efficacy.

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