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severe malaria

NOT Open Access | Red blood cell tension protects against severe malaria in the Dantu blood group

September 23, 2020 - 09:23 -- NOT Open Access
Author(s): 
Kariuki SN, Marin-Menendez A, Rayner JC, et al.
Reference: 
Nature. 2020 Sep 16

Malaria has had a major effect on the human genome, with many protective polymorphisms-such as the sickle-cell trait-having been selected to high frequencies in malaria-endemic regions1,2. The blood group variant Dantu provides 74% protection against all forms of severe malaria in homozygous individuals3-5, a similar degree of protection to that afforded by the sickle-cell trait and considerably greater than that offered by the best malaria vaccine.

Predictors of health workers’ knowledge about artesunate-based severe malaria treatment recommendations in government and faith-based hospitals in Kenya

July 29, 2020 - 10:11 -- Open Access
Author(s): 
Beatrice Machini, Dejan Zurovac, Beatrice Amboko, Lucas Malla, Robert W. Snow, Hillary Kipruto & Thomas N. O. Achia
Reference: 
Malaria Journal 2020 19:267, 23 July 2020

Health workers’ knowledge deficiencies about artesunate-based severe malaria treatment recommendations have been reported. However, predictors of the treatment knowledge have not been examined. In this paper, predictors of artesunate-based treatment knowledge among inpatient health workers in two hospital sectors in Kenya are reported.

Clinical trials to assess adjuvant therapeutics for severe malaria

July 27, 2020 - 12:35 -- Open Access
Author(s): 
Rosauro Varo, Clara Erice, Sydney Johnson, Quique Bassat and Kevin C. Kain
Reference: 
Malaria Journal 2020 19:268, 24 July 2020

Despite potent anti-malarial treatment, mortality rates associated with severe falciparum malaria remain high. To attempt to improve outcome, several trials have assessed a variety of potential adjunctive therapeutics, however none to date has been shown to be beneficial. This may be due, at least partly, to the therapeutics chosen and clinical trial design used. Here, we highlight three themes that could facilitate the choice and evaluation of putative adjuvant interventions for severe malaria, paving the way for their assessment in randomized controlled trials.

Predictors of health workers’ knowledge about artesunate-based severe malaria treatment recommendations in government and faith-based hospitals in Kenya

July 27, 2020 - 12:08 -- Open Access
Author(s): 
Beatrice Machini, Dejan Zurovac, Beatrice Amboko, Lucas Malla, Robert W. Snow, Hillary Kipruto and Thomas N. O. Achia
Reference: 
Malaria Journal 2020 19:267, 23 July 2020

Health workers’ knowledge deficiencies about artesunate-based severe malaria treatment recommendations have been reported. However, predictors of the treatment knowledge have not been examined. In this paper, predictors of artesunate-based treatment knowledge among inpatient health workers in two hospital sectors in Kenya are reported.

Plasmodium spp. mixed infection leading to severe malaria: a systematic review and meta-analysis

July 8, 2020 - 15:36 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, De Jesus Milanez G, Masangkay FR
Reference: 
Sci Rep. 2020 Jul 6;10(1):11068

Mixed Plasmodium malaria infections can lead to severe malaria. This systematic review and meta-analysis aimed to explore the prevalence of severe mixed Plasmodium malaria infection and to compare it with the prevalence of severe P. falciparum malaria mono-infection across the included studies. Original English-language research articles from PubMed, Scopus, and ISI Web of Science were identified and screened.

Parasite density in severe malaria in Colombia

June 26, 2020 - 15:31 -- Open Access
Author(s): 
Padilla-Rodríguez JC, Olivera MJ, Guevara-García BD
Reference: 
PLoS One. 2020 Jun 23;15(6):e0235119

Colombia has officially adopted the parasite density levels of severe malaria established by the WHO (>50,000 parasites/μl). These values have been inferred from areas of high transmission in Africa and are not consistent with the dynamics of low and unstable transmission in Colombia. The objective of this study was therefore to determine the parasite density values observed in patients with severe malaria and their distribution in the different ecoepidemiological regions of Colombia.

Bacteremia in adults with severe malaria

June 8, 2020 - 15:45 -- Open Access
Author(s): 
White NJ
Reference: 
Clin Infect Dis. 2020 Jun 7:ciaa733

Symptomatic malaria is predominantly a disease of childhood in areas of higher transmission (i.e. much of sub-Saharan Africa). Most cases of severe malaria occur in children less than 5 years of age. In these regions both malaria and sepsis are major causes of childhood death, yet the clinical distinction between the two is difficult, particularly if there is no obvious focus of infection. Furthermore, severe malaria predisposes to bacterial infections, particularly with Salmonella sp, so a very sick child  may have both.

NOT Open Access | Delayed iron does not alter cognition or behavior among children with severe malaria and iron deficiency

May 14, 2020 - 12:28 -- NOT Open Access
Author(s): 
Ssemata AS, Hickson M, Ssenkusu JM, Cusick SE, Nakasujja N, Opoka RO, Kroupina M, Georgieff MK, Bangirana P, John CC
Reference: 
Pediatr Res. 2020 May 13

Malaria and iron deficiency (ID) in childhood are both associated with cognitive and behavioral dysfunction. The current standard of care for children with malaria and ID is concurrent antimalarial and iron therapy. Delaying iron therapy until inflammation subsides could increase iron absorption but also impair cognition.

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